On the cover
An electron micrograph shows a cluster of Drosophila photoreceptor cells lacking the apical membrane protein Crumbs, which degenerate upon exposure to light. Chartier et al. reveal that Crumbs protects retinal cells by limiting the production of reactive oxygen species by Rac1 and NADPH oxidase.
Image courtesy of François Chartier.
See page 991.
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People & Ideas
The cell biology of disease
Different cyclin types have distinct abilities to reverse the S-phase checkpoint, and timely entry into mitosis after embryonic S phase requires collaborative action of multiple cyclin types.
Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death
Crb fulfills a protective role during light exposure by limiting oxidative damage resulting from Rac1–NADPH oxidase complex activity.
A PHD12–Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition
Snail2 and the adaptor protein PHD12 are recruited to the Cad6b promoter by Sin3A and result in promoter deacetylation, revealing the nature of the in vivo Snail repressive complex that regulates neural crest EMT.
Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis
By controlling cell spreading, physical confinement of cells limits peripheral actin contractility and thereby promotes polarity establishment, centrosome positioning, and subsequent lumen formation by epithelial cells.
INF2 promotes the formation of detyrosinated microtubules necessary for centrosome reorientation in T cells
The formin INF2 promotes the formation of stabilized, detyrosinated microtubules, which are important for centrosome reorientation to the immunological synapse of T cells.
Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation
The asymmetric cortical localization of dynein during spindle orientation requires dynein light chain 1 and a spindle-microtubule–associated adaptor formed by CHIA and HMMR.
Synaptic plasticity correlates with the local dendritic translocation of CaMKII in a Ca2+- and microtubule-dependent manner.
Sperm use temporal sampling, resetting of intracellular calcium level, and adaptation of their sensitivity to respond to a wide range of chemoattractant concentrations during their voyage toward the egg.