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In This Issue

In Focus

Study shows how a sperm's behavior shapes its swimming path.

People & Ideas

Lim is creating new biological systems from the parts evolution provided.


We are pleased to welcome several new JCB editorial board members.


The cell biology of disease


Different cyclin types have distinct abilities to reverse the S-phase checkpoint, and timely entry into mitosis after embryonic S phase requires collaborative action of multiple cyclin types.

Lipin-mediated production of diacylglycerol activates PKC and is critical for lamin disassembly during open mitosis.

Crb fulfills a protective role during light exposure by limiting oxidative damage resulting from Rac1–NADPH oxidase complex activity.


Snail2 and the adaptor protein PHD12 are recruited to the Cad6b promoter by Sin3A and result in promoter deacetylation, revealing the nature of the in vivo Snail repressive complex that regulates neural crest EMT.

By controlling cell spreading, physical confinement of cells limits peripheral actin contractility and thereby promotes polarity establishment, centrosome positioning, and subsequent lumen formation by epithelial cells.

The formin INF2 promotes the formation of stabilized, detyrosinated microtubules, which are important for centrosome reorientation to the immunological synapse of T cells.

The asymmetric cortical localization of dynein during spindle orientation requires dynein light chain 1 and a spindle-microtubule–associated adaptor formed by CHIA and HMMR.

Synaptic plasticity correlates with the local dendritic translocation of CaMKII in a Ca2+- and microtubule-dependent manner.

Sperm use temporal sampling, resetting of intracellular calcium level, and adaptation of their sensitivity to respond to a wide range of chemoattractant concentrations during their voyage toward the egg.

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