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Cover Image
Cover Image
On the cover
In a C. elegans L4 larva, the acyl-CoA synthetase ACS-22/FATP1 (green) localizes to the endoplasmic reticulum, whereas the diacylglycerol acyltransferase DGAT2 (red) resides on lipid droplets. Xu et al. reveal that FATP1 and DGAT2 form a complex at the ER–lipid droplet interface to promote triglyceride synthesis and lipid droplet expansion.
Image courtesy of Ningyi Xu.
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In This Issue
In Focus
Putting SUMO and SoxE into context
Study reveals how SUMOylation converts a transcriptional activator into a repressor.
People & Ideas
Tannishtha Reya: Classic pathways, new views on cancer
Reya studies how the balance between self-renewal and commitment is disrupted in cancer.
Review
Report
γ-Tubulin plays a key role in inactivating APC/CCdh1 at the G1–S boundary
Failure to inactivate APC/CCdhA at the G1–S boundary of the cell cycle as a result of a γ-tubulin mutation that disrupts the APC/CCdhA localization prevents cell cycle progression.
Rad53 is essential for a mitochondrial DNA inheritance checkpoint regulating G1 to S progression
Loss of mitochondrial DNA activates the DNA damage checkpoint kinase Rad53 to inhibit G1- to S-phase progression in budding yeast.
Article
SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest
SUMOylation of SoxE alters its recruitment of transcriptional coregulatory factors, displacing the binding of coactivators and promoting the recruitment of the corepressor Grg4.
Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration
Six1 in satellite cells is important for muscle regeneration and homeostasis of the stem cell niche by regulating MyoD, Myogenin, and Dusp6-ERK signaling.
Organelle positioning in muscles requires cooperation between two KASH proteins and microtubules
The KASH proteins Klar and MSP-300 cooperate to promote even myonuclear spacing by linking the MSP-300 nuclear ring to the astral microtubule network.
Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis
Human chromokinesins hKID and KIF4A contribute to proper attachment of chromosomes by controlling the positioning of the chromosome arms and microtubule dynamics, respectively.
CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis
CYK4 activity as a GTPase-activating protein is required during anaphase to inhibit Rac1-dependent effector pathways associated with control of cell spreading and adhesion.
Bacterial protein translocation requires only one copy of the SecY complex in vivo
In vivo probing of the oligomeric state of SecY during co- and post-translational translocation reveals that oligomerization is not required for this process.
The FATP1–DGAT2 complex facilitates lipid droplet expansion at the ER–lipid droplet interface
A complex between the ER resident protein FATP1 and the lipid droplet–localized DGAT2 protein facilitates lipid droplet expansion in C. elegans and mammalian cells.
Polarity and asymmetry in the arrangement of dynein and related structures in the Chlamydomonas axoneme
Cryoelectron tomography and subtomogram averaging reveal a high degree of structural asymmetry and polarization in dynein localization in the Chlamydomonas flagella.
Dishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity
Rpgrip1l is required for planar localization of the basal body and acts within a ciliopathy protein complex by stabilizing dishevelled.
Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1
Nodal, acting through Prex1 and Rac1, promotes dynamic actin and random motility in endodermal cells during early gastrulation.
