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    In a C. elegans L4 larva, the acyl-CoA synthetase ACS-22/FATP1 (green) localizes to the endoplasmic reticulum, whereas the diacylglycerol acyltransferase DGAT2 (red) resides on lipid droplets. Xu et al. reveal that FATP1 and DGAT2 form a complex at the ER–lipid droplet interface to promote triglyceride synthesis and lipid droplet expansion.
    Image courtesy of Ningyi Xu.
    See page 895.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Study reveals how SUMOylation converts a transcriptional activator into a repressor.

People & Ideas

Reya studies how the balance between self-renewal and commitment is disrupted in cancer.



Failure to inactivate APC/CCdhA at the G1–S boundary of the cell cycle as a result of a γ-tubulin mutation that disrupts the APC/CCdhA localization prevents cell cycle progression.

Loss of mitochondrial DNA activates the DNA damage checkpoint kinase Rad53 to inhibit G1- to S-phase progression in budding yeast.


SUMOylation of SoxE alters its recruitment of transcriptional coregulatory factors, displacing the binding of coactivators and promoting the recruitment of the corepressor Grg4.

Six1 in satellite cells is important for muscle regeneration and homeostasis of the stem cell niche by regulating MyoD, Myogenin, and Dusp6-ERK signaling.

The KASH proteins Klar and MSP-300 cooperate to promote even myonuclear spacing by linking the MSP-300 nuclear ring to the astral microtubule network.

Human chromokinesins hKID and KIF4A contribute to proper attachment of chromosomes by controlling the positioning of the chromosome arms and microtubule dynamics, respectively.

CYK4 activity as a GTPase-activating protein is required during anaphase to inhibit Rac1-dependent effector pathways associated with control of cell spreading and adhesion.

In vivo probing of the oligomeric state of SecY during co- and post-translational translocation reveals that oligomerization is not required for this process.

A complex between the ER resident protein FATP1 and the lipid droplet–localized DGAT2 protein facilitates lipid droplet expansion in C. elegans and mammalian cells.

Cryoelectron tomography and subtomogram averaging reveal a high degree of structural asymmetry and polarization in dynein localization in the Chlamydomonas flagella.

Rpgrip1l is required for planar localization of the basal body and acts within a ciliopathy protein complex by stabilizing dishevelled.

Nodal, acting through Prex1 and Rac1, promotes dynamic actin and random motility in endodermal cells during early gastrulation.

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