On the cover
A proximity ligation assay identifies complexes (red) containing the Notch1 receptor and the heparan sulfate proteoglycan Syndecan-3 in skeletal muscle satellite cells stained for Syndecan-4 (green). Pisconti et al. show that Syndecan-3 is required for Notch1's cleavage by the metalloproteinase ADAM17 and downstream signaling controlling satellite cell proliferation and differentiation.
See page 427.
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
In This Issue
People & Ideas
Activated Akt suppresses checkpoint activation by cells in late G2: although they are able to detect DNA damage, the repair pathway is put on hold until mitosis is complete.
SHIP2 is recruited early to clathrin-coated pits by the scaffold protein intersectin and dissociates before fission.
p125A is an accessory protein for COPII-mediated vesicle budding that links the Sec13/Sec31 and Sec23/24 subcomplexes.
The crystal structure of a Sec13–Sec16 complex reveals its functions in the early steps of COPII coat complex assembly.
Movement of the ER and mitochondria is coupled by limited interactions of the ER with a subset of posttranslationally modified microtubules.
Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL
A systems biology–based approach shows that life and death decisions for cells depend on the stoichiometry of c-FLIP isoforms.
Oxidant stress induces constitutive calcium entry by tacking glutathiones onto the Orai CRAC channel activator STIM1.
Turnover of endosomal PI(3)P by mtm maintains endolysosomal homeostasis and cortical remodeling in Drosophila hemocytes during migration.
KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC
Cell polarity is determined in part by Kif17-mediated regulation of microtubule dynamics and polymerization rates.
Ephexin4 is a RhoG-specific guanine nucleotide exchange factor that interacts with the EphA2 receptor in breast cancer cells.