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Cover Image
Cover Image
On the cover
A proximity ligation assay identifies complexes (red) containing the Notch1 receptor and the heparan sulfate proteoglycan Syndecan-3 in skeletal muscle satellite cells stained for Syndecan-4 (green). Pisconti et al. show that Syndecan-3 is required for Notch1's cleavage by the metalloproteinase ADAM17 and downstream signaling controlling satellite cell proliferation and differentiation.
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In This Issue
In Focus
FLIPping the kill switch
The amounts of different cFLIP isoforms help cells choose between life and death.
People & Ideas
Review
Report
Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2
Activated Akt suppresses checkpoint activation by cells in late G2: although they are able to detect DNA damage, the repair pathway is put on hold until mitosis is complete.
The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics
SHIP2 is recruited early to clathrin-coated pits by the scaffold protein intersectin and dissociates before fission.
Article
γ-Tubulin regulates the anaphase-promoting complex/cyclosome during interphase
Activation of the APC/C requires microtubule-nucleating independent aspects of γ-tubulin function.
p125A exists as part of the mammalian Sec13/Sec31 COPII subcomplex to facilitate ER-Golgi transport
p125A is an accessory protein for COPII-mediated vesicle budding that links the Sec13/Sec31 and Sec23/24 subcomplexes.
Structure of the Sec13–Sec16 edge element, a template for assembly of the COPII vesicle coat
The crystal structure of a Sec13–Sec16 complex reveals its functions in the early steps of COPII coat complex assembly.
ER sliding dynamics and ER–mitochondrial contacts occur on acetylated microtubules
Movement of the ER and mitochondria is coupled by limited interactions of the ER with a subset of posttranslationally modified microtubules.
Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL
A systems biology–based approach shows that life and death decisions for cells depend on the stoichiometry of c-FLIP isoforms.
S-glutathionylation activates STIM1 and alters mitochondrial homeostasis
Oxidant stress induces constitutive calcium entry by tacking glutathiones onto the Orai CRAC channel activator STIM1.
Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions
Turnover of endosomal PI(3)P by mtm maintains endolysosomal homeostasis and cortical remodeling in Drosophila hemocytes during migration.
Syndecan-3 and Notch cooperate in regulating adult myogenesis
Syndecan-3 is required for Notch processing by ADAM17/TACe and therefore regulates proliferation and viability of muscle satellite cells.
KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC
Cell polarity is determined in part by Kif17-mediated regulation of microtubule dynamics and polymerization rates.
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism
Ephexin4 is a RhoG-specific guanine nucleotide exchange factor that interacts with the EphA2 receptor in breast cancer cells.
