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Cover Image
Cover Image
On the cover
Quinones et al. find that competition between pro- and anti-endocytic BAR domain proteins directs cell migration by regulating the trafficking and activity of guidance cue receptors. Border cells (top) don't migrate toward the ovary (bottom) in Drosophila egg chambers lacking the endocytic inhibitor Missing-In-Metastasis. The egg chambers are stained for F-actin (red), phosphotyrosine (green), and DNA (blue).
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In This Issue
In Focus
Deciding what to eat
A signaling pathway directs cells to degrade peroxisomes while leaving other organelles untouched.
People & Ideas
Laurie Glimcher: Merging cell biology and immune function
Glimcher pursues a cross-disciplinary understanding of how cell biology affects the immune system.
Editorial
Review
Report
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
Defective mitochondrial quality control is shown to be a mechanism for neurodegeneration in some forms of Parkinson's disease.
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C
A screen in oligodendrocytes establishes a Rab family member and its GAPs as regulators of exosome secretion by controlling endocytic vesicle docking with the plasma membrane.
Article
Continued primer synthesis at stalled replication forks contributes to checkpoint activation
An increased number of primer–template junctions generated by PCNA, Pol-δ, and Pol-ε at stalled replication forks activates Chk1.
Activation of cyclin B1–Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis
A biosensor for cyclin B–Cdk1 activity shows that it uses an unconventional yet simple mechanism for nuclear accumulation.
Hsp90–Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore–microtubule binding sites
The Hsp90–Sgt1 chaperone and the ubiquitin ligase subunit Skp1 regulate the assembly and turnover of the kinetochore complex Mis12.
LGN regulates mitotic spindle orientation during epithelial morphogenesis
Disrupting LGN’s function at lateral membrane domains displaces the axis of cell division in cyst-forming MDCK cells.
HPat provides a link between deadenylation and decapping in metazoa
A proline-rich region in the Drosophila Pat1 homologue works with the protein's C-terminal domain to recruit decapping and deadenylase complexes to target mRNAs.
A yeast MAPK cascade regulates pexophagy but not other autophagy pathways
The S. cerevisiae Slt2p MAPK cascade picks out peroxisomes for autophagy-mediated degradation (pexophagy) but is not involved in turnover of other cellular components.
Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane
In the absence of moesin, RhoA slips out of its normal role as a GTPase to activate the JNK MAPK pathway and spur apoptosis.
Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors
The Notch intracellular domain and β-catenin team up with RBP-J to regulate gene transcription and promote the development of arterial endothelial cells.
αE-catenin regulates actin dynamics independently of cadherin-mediated cell–cell adhesion
αE-catenin has cell–cell contact–dependent and –independent functions in regulating actin and membrane dynamics.
I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration
The I-BAR domain–containing protein, missing-in-metastasis, directs cell motility by opposing the endocytic activity of the endophilin–CD2AP–cortactin complex.
αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration
Loss of β3 integrin enhances turnover of focal adhesions and cell migration speed due to increased β1 integrin–talin interactions.
