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JCB65: Trafficking and Organelles

In the eleventh collection celebrating our 65th anniversary, we revisit field-defining work informing cell biologists about organelle biogenesis and function, membrane traffic, protein sorting, quality control, and host–pathogen interactions at membranes. Rediscover work laying the foundation for membrane trafficking/recycling at the synapse, defining the retromer complex, identifying new roles for Rab GTPases in cellular trafficking, and characterizing modes of cellular transport, as well as early studies of retrograde transport and Golgi biogenesis, the characterization of transport intermediates, and the mechanisms involved in protein quality control and secretion. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or email us at jcellbiol@rockefeller.edu. Find more 65th anniversary collections or browse our From the Archive series.

Image from Heuser and Reese, 1973.

Report

Filopodia mediate ER-targeted exosome uptake

Wolf Heusermann; Justin Hean; Dominic Trojer; Emmanuelle Steib; Stefan von Bueren; Alexandra Graff-Meyer; Christel Genoud; Katrin Martin; Nicolas Pizzato; Johannes Voshol; David V. Morrissey; Samir E.L. Andaloussi; Matthew J. Wood; Nicole C. Meisner-Kober

10.1083/jcb.201506084

Article

Position of lysosomes determines their luminal pH

Danielle E. Johnson; Philip Ostrowski; Valentin Jaumouillé; Sergio Grinstein

10.1083/jcb.201507112

Article

Characterization of the CLIC pathway

Mark T. Howes; Matthew Kirkham; James Riches; Katia Cortese; Piers J. Walser; Fiona Simpson; Michelle M. Hill; Alun Jones; Richard Lundmark; Margaret R. Lindsay; Delia J. Hernandez-Deviez; Gordana Hadzic; Adam McCluskey; Rumasia Bashir; Libin Liu; Paul Pilch; Harvey McMahon; Phillip J. Robinson; John F. Hancock; Satyajit Mayor; Robert G. Parton

10.1083/jcb.201002119

Report

Rab35 in exosome biogenesis

Chieh Hsu; Yuichi Morohashi; Shin-ichiro Yoshimura; Natalia Manrique-Hoyos; SangYong Jung; Marcel A. Lauterbach; Mostafa Bakhti; Mads Grønborg; Wiebke Möbius; JeongSeop Rhee; Francis A. Barr; Mikael Simons

10.1083/jcb.200911018

Article

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150^Glued and late endosome positioning

Nuno Rocha; Coenraad Kuijl; Rik van der Kant; Lennert Janssen; Diane Houben; Hans Janssen; Wilbert Zwart; Jacques Neefjes

10.1083/jcb.200811005

Article

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

Raul Rojas; Thijs van Vlijmen; Gonzalo A. Mardones; Yogikala Prabhu; Adriana L. Rojas; Shabaz Mohammed; Albert J.R. Heck; Graça Raposo; Peter van der Sluijs; Juan S. Bonifacino

10.1083/jcb.200804048

Article

Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFα

Anthony P. Manderson; Jason G. Kay; Luke A. Hammond; Darren L. Brown; Jennifer L. Stow

10.1083/jcb.200612131

Article

Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells

Agnes Lee Ang; Tomohiko Taguchi; Stephen Francis; Heike Fölsch; Lindsay J. Murrells; Marc Pypaert; Graham Warren; Ira Mellman

10.1083/jcb.200408165

Article

Vps27 recruits ESCRT machinery to endosomes during MVB sorting

David J. Katzmann; Christopher J. Stefan; Markus Babst; Scott D. Emr