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Volume 152, Issue 4
19 February 2001
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    Cover picture:The Rab27a GTPase associates with melanosomes and regulates their transport to, and retention in, the peripheral cytoplasm in skin melanocytes. Melanosome transport also requires the microtubule and actin cytoskeleton. Staining of a cultured murine melanocyte for filamentous actin (red) and microtubules (blue) reveals a close relationship between Rab27a-labelled melanosomes (green) and these cytoskeletal elements. See related article in this issue by Hume et al., 795-808.
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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In This Issue
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Article

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
In Special Collection: JCB65: Autophagy
Noboru Mizushima,Akitsugu Yamamoto,Masahiko Hatano,Yoshinori Kobayashi,Yukiko Kabeya,Kuninori Suzuki,Takeshi Tokuhisa,Yoshinori Ohsumi,Tamotsu Yoshimori
View Articletitled, Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis
Régis Giet,David M. Glover
View Articletitled, <em>Drosophila</em> Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis
Connection of the Mitochondrial Outer and Inner Membranes by Fzo1 Is Critical for Organellar Fusion
Stefan Fritz,Doron Rapaport,Elisabeth Klanner,Walter Neupert,Benedikt Westermann
View Articletitled, Connection of the Mitochondrial Outer and Inner Membranes by Fzo1 Is Critical for Organellar Fusion
Stromelysin-1 Regulates Adipogenesis during Mammary Gland Involution
Caroline M. Alexander,Sushma Selvarajan,John Mudgett,Zena Werb
View Articletitled, Stromelysin-1 Regulates Adipogenesis during Mammary Gland Involution
Hsp70 and Antifibrillogenic Peptides Promote Degradation and Inhibit Intracellular Aggregation of Amyloidogenic Light Chains
Jeanne L. Dul,David P. Davis,Edward K. Williamson,Fred J. Stevens,Yair Argon
View Articletitled, Hsp70 and Antifibrillogenic Peptides Promote Degradation and Inhibit Intracellular Aggregation of Amyloidogenic Light Chains
A Specific Role of Phosphatidylinositol 3–Kinase γ: A Regulation of Autonomic Ca2+ Oscillations in Cardiac Cells
Claire Bony,Serge Roche,Ueno Shuichi,Takehiko Sasaki,Michael A. Crackower,Josef Penninger,Hiroyuki Mano,Michel Pucéat
View Articletitled, A Specific Role of Phosphatidylinositol 3–Kinase γ<span class="subtitle-colon">: </span><span class="subtitle">A Regulation of Autonomic Ca<sup>2</sup>+ Oscillations in Cardiac Cells</span>
The Karyopherin Kap142p/Msn5p Mediates Nuclear Import and Nuclear Export of Different Cargo Proteins
Kimihisa Yoshida,Günter Blobel
View Articletitled, The Karyopherin Kap142p/Msn5p Mediates Nuclear Import and Nuclear Export of Different Cargo Proteins
Plasminogen Activator Inhibitor 1 Functions as a Urokinase Response Modifier at the Level of Cell Signaling and Thereby Promotes Mcf-7 Cell Growth
Donna J. Webb,Keena S. Thomas,Steven L. Gonias
View Articletitled, Plasminogen Activator Inhibitor 1 Functions as a Urokinase Response Modifier at the Level of Cell Signaling and Thereby Promotes Mcf-7 Cell Growth
Activation of Nuclear Factor κb and bcl-x Survival Gene Expression by Nerve Growth Factor Requires Tyrosine Phosphorylation of IκBα
Nguyen Truc Bui,Antonia Livolsi,Jean-Francois Peyron,Jochen H.M. Prehn
View Articletitled, Activation of Nuclear Factor κb and <em>bcl-x</em> Survival Gene Expression by Nerve Growth Factor Requires Tyrosine Phosphorylation of IκBα
A Novel 14-Kilodalton Protein Interacts with the Mitogen-Activated Protein Kinase Scaffold Mp1 on a Late Endosomal/Lysosomal Compartment
Winfried Wunderlich,Irene Fialka,David Teis,Arno Alpi,Andrea Pfeifer,Robert G. Parton,Friedrich Lottspeich,Lukas A. Huber
View Articletitled, A Novel 14-Kilodalton Protein Interacts with the Mitogen-Activated Protein Kinase Scaffold Mp1 on a Late Endosomal/Lysosomal Compartment
The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin: Implications for Antiangiogenic Strategies
Khalid Bajou,Véronique Masson,Robert D. Gerard,Petra M. Schmitt,Valérie Albert,Michael Praus,Leif R. Lund,Thomas L. Frandsen,Nils Brunner,Keld Dano,Norbert E. Fusenig,Ulrich Weidle,Geert Carmeliet,David Loskutoff,Desiré Collen,Peter Carmeliet,Jean Michel Foidart,Agnès Noël
View Articletitled, The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin<span class="subtitle-colon">: </span><span class="subtitle">Implications for Antiangiogenic Strategies</span>
Presenilin 1 Negatively Regulates β-Catenin/T Cell Factor/Lymphoid Enhancer Factor-1 Signaling Independently of β-Amyloid Precursor Protein and Notch Processing
Salvador Soriano,David E. Kang,Maofu Fu,Richard Pestell,Nathalie Chevallier,Hui Zheng,Edward H. Koo
View Articletitled, Presenilin 1 Negatively Regulates β-Catenin/T Cell Factor/Lymphoid Enhancer Factor-1 Signaling Independently of β-Amyloid Precursor Protein and Notch Processing
Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes
In Special Collection: JCB65: Trafficking and Organelles
Alistair N. Hume,Lucy M. Collinson,Andrzej Rapak,Anita Q. Gomes,Colin R. Hopkins,Miguel C. Seabra
View Articletitled, Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes
Distinct Protein Sorting and Localization to Premelanosomes, Melanosomes, and Lysosomes in Pigmented Melanocytic Cells✪
Graça Raposo,Danielle Tenza,Diane M. Murphy,Joanne F. Berson,Michael S. Marks
View Articletitled, Distinct Protein Sorting and Localization to Premelanosomes, Melanosomes, and Lysosomes in Pigmented Melanocytic Cells<sup>✪</sup>
Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes
In Special Collection: JCB65: Trafficking and Organelles
Jane C. Stinchcombe,Duarte C. Barral,Emilie H. Mules,Sarah Booth,Alistair N. Hume,Laura M. Machesky,Miguel C. Seabra,Gillian M. Griffiths
View Articletitled, Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes
Defective Granule Exocytosis in Rab27a-Deficient Lymphocytes from Ashen Mice
Elias K. Haddad,Xufeng Wu,John A. Hammer, III,Pierre A. Henkart
View Articletitled, Defective Granule Exocytosis in Rab27a-Deficient Lymphocytes from <em>Ashen</em> Mice

Report

Rab27a: A Key to Melanosome Transport in Human Melanocytes
Philippe Bahadoran,Edith Aberdam,Frédéric Mantoux,Roser Buscà,Karine Bille,Nevin Yalman,Geneviève de Saint-Basile,Ricardo Casaroli-Marano,Jean-Paul Ortonne,Robert Ballotti
View Articletitled, Rab27a<span class="subtitle-colon">: </span><span class="subtitle">A Key to Melanosome Transport in Human Melanocytes</span>
An Essential Role for the Substrate-Binding Region of Hsp40s in Saccharomyces cerevisiae
Jill L. Johnson,Elizabeth A. Craig
View Articletitled, An Essential Role for the Substrate-Binding Region of Hsp40s in <em>Saccharomyces cerevisiae</em>

Review

Where Notch and WNT Signaling Meet: The Presenilin Hub
Bart De Strooper,Wim Annaert
View Articletitled, Where Notch and WNT Signaling Meet<span class="subtitle-colon">: </span><span class="subtitle">The Presenilin Hub</span>
Of Yeast, Mice, and Men: Rab Proteins and Organelle Transport
Sean W. Deacon,Vladimir I. Gelfand
View Articletitled, Of Yeast, Mice, and Men<span class="subtitle-colon">: </span><span class="subtitle">Rab Proteins and Organelle Transport</span>

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