JCB65: Cell Division, Cell Cycle, and Polarity

In the third collection celebrating our 65th anniversary, we explore studies laying the foundation of our understanding of cell polarity, such as the identification of Cdc42. The collection encompasses fundamental and paradigm-changing work in the cell cycle field, including the demonstration of independent cell cycles within a multinucleate. We also revisit studies that precisely dissect the mechanics of cell division. Find early studies dissecting the functions of Aurora B in mitosis; the demonstration that a checkpoint monitors chromosome biorientation to ensure fidelity of chromosome segregation during mitosis; the first purification of the yeast spindle pole body and development of mAbs that successfully identify its components; and the first description of the Augmin complex, which is essential for spindle-mediated microtubule nucleation. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or email jcellbiol@rockefeller.edu. Find more 65th anniversary collections or browse our From the Archive series.

Image from Mabuchi and Okuno, 1977