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Journal Articles

Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes

Kerry S. McDonald, Theodore J. Kalogeris, Adam B. Veteto, Daniel J. Davis, Laurin M. Hanft
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (3): e202413678.
https://doi.org/10.1085/jgp.202413678
Published: 24 March 2025
View articletitled, Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes
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Journal Articles

Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band

Dalma Kellermayer, Cristina M. Șulea, Hedvig Tordai, Kálmán Benke, Miklós Pólos, Bence Ágg, Roland Stengl, Máté Csonka, Tamás Radovits, Béla Merkely, Zoltán Szabolcs, Miklós Kellermayer, Balázs Kiss
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (3): e202413690.
https://doi.org/10.1085/jgp.202413690
Published: 10 March 2025
View articletitled, Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band
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Includes: Supplementary data
Journal Articles

Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium

Tuan A. Phan, Daniel P. Fitzsimons
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e202413582.
https://doi.org/10.1085/jgp.202413582
Published: 27 January 2025
View articletitled, Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium
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Includes: Supplementary data
Journal Articles

Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy

Jonathan Schreiber, Ludivine Rotard, Yves Tourneur, Aude Lafoux, Christine Berthier, Bruno Allard, Corinne Huchet, Vincent Jacquemond
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413588.
https://doi.org/10.1085/jgp.202413588
Published: 24 December 2024
View articletitled, Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy
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Journal Articles

Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency

Amy D. Hanna, Ting Chang, Kevin S. Ho, Rachel Sue Zhen Yee, William Cameron Walker, Nadia Agha, Chih-Wei Hsu, Sung Yun Jung, Mary E. Dickinson, Md. Abul Hassan Samee, Christopher S. Ward, Chang Seok Lee, George G. Rodney, Susan L. Hamilton
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413583.
https://doi.org/10.1085/jgp.202413583
Published: 11 December 2024
View articletitled, Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency
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Includes: Supplementary data
Journal Articles

Stochastic force generation in an isometric binary mechanical system

Vidya Murthy, Josh E. Baker
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313493.
https://doi.org/10.1085/jgp.202313493
Published: 19 November 2024
View articletitled, Stochastic force generation in an isometric binary mechanical system
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Includes: Supplementary data
Journal Articles

Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1

Mathilde Dubois, Florian Pallot, Maxime Gouin-Gravezat, Doria Boulghobra, Florence Coste, Guillaume Walther, Gregory Meyer, Isabelle Bornard, Cyril Reboul
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313485.
https://doi.org/10.1085/jgp.202313485
Published: 07 November 2024
View articletitled, Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1
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Includes: Supplementary data
Journal Articles

Stable oxidative posttranslational modifications alter the gating properties of RyR1

Maarten M. Steinz, Nicole Beard, Emily Shorter, Johanna T. Lanner
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313515.
https://doi.org/10.1085/jgp.202313515
Published: 05 November 2024
View articletitled, Stable oxidative posttranslational modifications alter the gating properties of RyR1
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Includes: Supplementary data
Journal Articles

Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle

Andrew F. Mead, Neil B. Wood, Shane R. Nelson, Bradley M. Palmer, Lin Yang, Samantha Beck Previs, Angela Ploysangngam, Guy G. Kennedy, Jennifer F. McAdow, Sarah M. Tremble, Marcus A. Zimmermann, Marilyn J. Cipolla, Alicia M. Ebert, Aaron N. Johnson, Christina A. Gurnett, Michael J. Previs, David M. Warshaw
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2024) 156 (12): e202413604.
https://doi.org/10.1085/jgp.202413604
Published: 07 October 2024
View articletitled, Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle
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Includes: Supplementary data
Journal Articles

Calcium has a direct effect on thick filament activation in porcine myocardium

Saffie Mohran, Timothy S. McMillen, Christian Mandrycky, An-Yue Tu, Kristina B. Kooiker, Wenjing Qian, Stephanie Neys, Brayan Osegueda, Farid Moussavi-Harami, Thomas C. Irving, Michael Regnier, Weikang Ma
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202413545.
https://doi.org/10.1085/jgp.202413545
Published: 20 September 2024
View articletitled, Calcium has a direct effect on thick filament activation in porcine myocardium
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Journal Articles

Modeling the mechanism of Ca2+ release in skeletal muscle by DHPRs easing inhibition at RyR I1-sites

D. George Stephenson
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2024) 156 (10): e202213113.
https://doi.org/10.1085/jgp.202213113
Published: 04 September 2024
View articletitled, Modeling the mechanism of Ca2+ release in skeletal muscle by DHPRs easing inhibition at RyR I1-sites
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Includes: Supplementary data
Journal Articles

Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor

Kristina Kooiker, Qing-Fen Gan, Ming Yu, Na Sa, Saffie Mohran, Yuanhua Cheng, Galina Flint, Stephanie Neys, Chengqian Gao, Devin Nissen, Tim McMillen, Anthony Asencio, Weikang Ma, Thomas C. Irving, Farid Moussavi-Harami, Michael Regnier
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (10): e202313503.
https://doi.org/10.1085/jgp.202313503
Published: 31 July 2024
View articletitled, Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor
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Includes: Supplementary data
Journal Articles

Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state

Sebastian Duno-Miranda, Shane R. Nelson, David V. Rasicci, Skylar M.L. Bodt, Joseph A. Cirilo, Jr, Duha Vang, Sivaraj Sivaramakrishnan, Christopher M. Yengo, David M. Warshaw
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (6): e202313522.
https://doi.org/10.1085/jgp.202313522
Published: 06 May 2024
View articletitled, Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state
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Includes: Supplementary data
Journal Articles

Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

Michael J. Rynkiewicz, Matthew C. Childers, Olga E. Karpicheva, Michael Regnier, Michael A. Geeves, William Lehman
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (5): e202413538.
https://doi.org/10.1085/jgp.202413538
Published: 12 April 2024
View articletitled, Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin
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Includes: Supplementary data
Journal Articles

A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice

Sofia Benucci, Alexis Ruiz, Martina Franchini, Lucia Ruggiero, Dario Zoppi, Rebecca Sitsapesan, Chris Lindsay, Pawel Pelczar, Laura Pietrangelo, Feliciano Protasi, Susan Treves, Francesco Zorzato
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (4): e202313486.
https://doi.org/10.1085/jgp.202313486
Published: 04 March 2024
View articletitled, A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice
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Includes: Supplementary data
Journal Articles

Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy

Ricardo A. Galli, Tamara C. Borsboom, Charlotte Gineste, Lorenza Brocca, Maira Rossi, Darren T. Hwee, Fady I. Malik, Roberto Bottinelli, Julien Gondin, Maria-Antonietta Pellegrino, Josine M. de Winter, Coen A.C. Ottenheijm
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (4): e202313471.
https://doi.org/10.1085/jgp.202313471
Published: 20 February 2024
View articletitled, Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy
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Includes: Supplementary data
Journal Articles

Myosin and tropomyosin–troponin complementarily regulate thermal activation of muscles

In Special Collection:
Biophysics 2024
Shuya Ishii, Kotaro Oyama, Fuyu Kobirumaki-Shimozawa, Tomohiro Nakanishi, Naoya Nakahara, Madoka Suzuki, Shin’ichi Ishiwata, Norio Fukuda
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (12): e202313414.
https://doi.org/10.1085/jgp.202313414
Published: 23 October 2023
View articletitled, Myosin and tropomyosin–troponin complementarily regulate thermal activation of muscles
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Includes: Supplementary data
Journal Articles

IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels

Scott D. Zawieja, Grace A. Pea, Sarah E. Broyhill, Advaya Patro, Karen H. Bromert, Min Li, Charles E. Norton, Jorge A. Castorena-Gonzalez, Edward J. Hancock, Christopher D. Bertram, Michael J. Davis
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (12): e202313358.
https://doi.org/10.1085/jgp.202313358
Published: 18 October 2023
View articletitled, IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels
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Includes: Supplementary data
Journal Articles

A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP3R

Edward J. Hancock, Scott D. Zawieja, Charlie Macaskill, Michael J. Davis, Christopher D. Bertram
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (12): e202313355.
https://doi.org/10.1085/jgp.202313355
Published: 18 October 2023
View articletitled, A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP3R
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Journal Articles

Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle

Marco Caremani, Luca Fusi, Massimo Reconditi, Gabriella Piazzesi, Theyencheri Narayanan, Malcolm Irving, Vincenzo Lombardi, Marco Linari, Elisabetta Brunello
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (12): e202313393.
https://doi.org/10.1085/jgp.202313393
Published: 27 September 2023
View articletitled, Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle
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