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William Lehman
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Journal Articles

Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

Michael J. Rynkiewicz, Matthew C. Childers, Olga E. Karpicheva, Michael Regnier, Michael A. Geeves, William Lehman
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (5): e202413538.
https://doi.org/10.1085/jgp.202413538
Published: 12 April 2024
View article titled, Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin
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Includes: Supplementary data
Journal Articles

Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle

William Lehman, Michael J. Rynkiewicz
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (7): e202313387.
https://doi.org/10.1085/jgp.202313387
Published: 30 May 2023
View article titled, Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle
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Journal Articles

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

Matthew H. Doran, Michael J. Rynkiewicz, David Rasicci, Skylar M.L. Bodt, Meaghan E. Barry, Esther Bullitt, Christopher M. Yengo, Jeffrey R. Moore, William Lehman
Journal: Journal of General Physiology
Series: Myofilament Function 2022
J Gen Physiol (2023) 155 (3): e202213267.
https://doi.org/10.1085/jgp.202213267
Published: 12 January 2023
View article titled, Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin
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Journal Articles

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

Matthew H. Doran, Michael J. Rynkiewicz, Elumalai Pavadai, Skylar M.L. Bodt, David Rasicci, Jeffrey R. Moore, Christopher M. Yengo, Esther Bullitt, William Lehman
Journal: Journal of General Physiology
Series: Myofilament Function 2022
J Gen Physiol (2022) 155 (2): e202213274.
https://doi.org/10.1085/jgp.202213274
Published: 02 December 2022
View article titled, Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation
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Includes: Supplementary data
Journal Articles

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

Lorenzo R. Sewanan, Jinkyu Park, Michael J. Rynkiewicz, Alice W. Racca, Nikolaos Papoutsidakis, Jonas Schwan, Daniel L. Jacoby, Jeffrey R. Moore, William Lehman, Yibing Qyang, Stuart G. Campbell
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (9): e202012640.
https://doi.org/10.1085/jgp.202012640
Published: 28 July 2021
View article titled, Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation
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Journal Articles

The mechanism of thin filament regulation: Models in conflict?

Michael A. Geeves, Sherwin S. Lehrer, William Lehman
Journal: Journal of General Physiology
J Gen Physiol (2019) 151 (11): 1265–1271.
https://doi.org/10.1085/jgp.201912446
Published: 30 September 2019
View article titled, The mechanism of thin filament regulation: Models in conflict?
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Journal Articles

Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states

Farooq A. Kiani, William Lehman, Stefan Fischer, Michael J. Rynkiewicz
Journal: Journal of General Physiology
J Gen Physiol (2018) 151 (1): 4–8.
https://doi.org/10.1085/jgp.201812188
Published: 15 November 2018
View article titled, Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states
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Includes: Supplementary data
Journal Articles

Calcium-Dependent Myosin from Insect Flight Muscles

William Lehman, Belinda Bullard, Kathleen Hammond
Journal: Journal of General Physiology
J Gen Physiol (1974) 63 (5): 553–563.
https://doi.org/10.1085/jgp.63.5.553
Published: 01 May 1974
View article titled, Calcium-Dependent Myosin from Insect Flight Muscles
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Journal Articles

Activation of the Adenosine Triphosphatase of Limulus polyphemus Actomyosin by Tropomyosin

William Lehman, Andrew G. Szent-Györgyi
Journal: Journal of General Physiology
J Gen Physiol (1972) 59 (4): 375–387.
https://doi.org/10.1085/jgp.59.4.375
Published: 01 April 1972
View article titled, Activation of the Adenosine Triphosphatase of <em>Limulus polyphemus</em> Actomyosin by Tropomyosin
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