Issues

De Jesús-Pérez et al. show that a reciprocal regulation between key gating elements and permeant anions sets the calcium and voltage sensitivities and the anion selectivity of the calcium-activated chloride channel TMEM16A.

Naseem et al. show that the Cm28 peptide found in scorpion venom is a potent inhibitor of the K_V1.2 and K_V1.3 K⁺ channels. Cm28 is a pore blocker that obeys a unique primary structure with only 27 amino acid residues and the lack of the functional dyad characteristic of other α-KTx peptides.