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Research News

JGP study uses both natural and unnatural amino acid substitutions to examine how a key tyrosine residue controls the selectivity of the Na+/K+ pump.


Commentary highlighting valuable mechanistic insights provided by Klipp and Bankston on ASIC3 regulation by lipids.

Godellas and Grosman revisit equilibrium binding assays to shed new light on pentameric ligand-gated ion channels.


Mechanotransduction by Membrane Proteins

Young et al. review and synthesize the mechanistic principles of forces and energies involved in Piezo ion channel mechanotransduction.


Arachidonic acid (AA) is a known modulator of ASICs. Klipp and Bankston examine the structural requirements for ASIC modulation by a number of lipids related to AA. Negatively charged head groups are stronger potentiators and may interact with an arginine in TM1 near the outer leaflet of the plasma membrane.

Combining electrophysiology and kinetic modeling, Brake et al. highlight the role of closed-state inactivation in the gating behavior of cardiac, skeletal muscle, and neuronal voltage-gated sodium channels.

Spontarelli et al. show that Y780, a disease-relevant residue in the sodium pump’s sodium-exclusive ion-binding site, stabilizes sodium binding there through a hydrogen bond, without the participation of cation–π interactions and controls K+ interaction at the other two ion-binding sites indirectly through a hydrogen-bond network.

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