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Sanchez et al. target the Ca2+-sensitive dye CGaMP6f to the triad region of the sarcomere by using the T306 domain of triadin. Their approach reveals synchronous Ca2+ release across individual triads and will facilitate the study of ryanodine receptor channel function.

Martinez-Espinosa et al. show that fast and slow recovery of voltage-dependent Na+ (Nav) channels in rat adrenal chromaffin cells depends on two independent inactivation pathways. Competition between these pathways regulates changes in Nav channel availability.

Commentary

Accardi reviews data on the lysosomal 2 Cl/1 H+ antiporter ClC-7.

A new structure of a CLC antiporter mutant, along with EPR spectroscopy and computational dynamics, now resolves several basic puzzles regarding how these transporters stoichiometrically move Cl and H+ in opposite directions across biological membranes.

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