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Cover Image
Cover Image
Cover picture: The left panel shows a confocal image stack Z projection of an Alexa Fluor 488–filled molecular layer interneuron of the cerebellar cortex. The right panel shows the superimposition of the Alexa Fluor (magenta) signal with that of the presynaptic marker VGAT (vesicular GABA transporter; green). Colocalization of VGAT and Alexa Fluor indicates presynaptic release sites (see Research article by Zorrilla de San Martin, 477–493).
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Article
Asymmetric protonation of EmrE
The active-site glutamate 14 residues of the homodimeric multidrug transporter EmrE have distinct macroscopic pKa values, raising new questions regarding the coupling of proton import to drug efflux.
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Clinically important antiarrhythmic drugs may act by modifying primarily physical properties of the cell membrane.
Impact of single-site axonal GABAergic synaptic events on cerebellar interneuron activity
Presynaptic GABAA receptors have a greater influence than previously known.
Modulation of the slow/common gating of CLC channels by intracellular cadmium
Cd2+ binding to the CLC channel dimer interface inhibits slow gating by altering subunit interactions.
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When muscles become paralyzed in crises of hyperkalemic periodic paralysis, patients do not stop breathing. Here is why.
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Mutations that increase the activity of ATP-sensitive potassium channels through either enhanced activation by MgADP or decreased sensitivity to inhibition by ATP can lead to Cantú syndrome.
