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Cover Image
Cover Image
Cover picture: A key tryptophan (tan ball-and-stick) in the proton channel (mHV1 crystal structure shown extracellular end up) stabilizes the closed state, providing the roof of a pocket (protein–lipid interface cut away) within which the third arginine (blue) in the S4 helix interacts with an aspartate (red) and an asparagine (green). Local surface hydrophobicity to hydrophilicity shades from grey to pink (see Research article by Cherny et al., 343–356).
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Generally Physiological
Article
Tryptophan 207 is crucial to the unique properties of the human voltage-gated proton channel, hHV1
A conserved tryptophan uniquely present in the voltage-sensing domain of voltage-gated proton channels is surprisingly crucial to four channel-defining properties.
Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate
PIP2 mediates the bimodal regulation of the EAG family K+ channel ELK1 to produce an overall inhibitory effect.
Modal affinities of endplate acetylcholine receptors caused by loop C mutations
Modal activity at the nicotinic acetylcholine receptor, in which open channel probability switches reversibly between discrete values, arises from changes in the resting affinity at the agonist site.
Communication
Altered conductance and permeability of Cx40 mutations associated with atrial fibrillation
Alterations in the permeability and conductance of mutant atrial connexins may contribute to reentry arrhythmias.
A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization
A missense mutation in the pore-forming α subunit of a delayed rectifier Kv channel is associated with epileptic encephalopathy, alters the cation selectivity of voltage-gated currents, and disrupts channel expression and localization.
Family resemblances: A common fold for some dimeric ion-coupled secondary transporters
The structures of two bacterial antiporters that act as multidrug resistance efflux pumps, MtrF and YdaH, resemble each other and that of the sodium-coupled succinate symporter VcINDY.
