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Issues

ISSN 0022-1295
EISSN 1540-7748
In this Issue

Generally Physiological

Research Articles

One-dimensional diffusion of myosin light chain kinase along actin filaments enables the rapid phosphorylation of smooth muscle myosin.

The K+ affinity of the Na,K-ATPase α2 isoform matches its activity to the range of extracellular K+ concentrations in the T-tubules at rest and during contraction, maintaining the excitability of active muscle.

Alterations in the intracellular environment lead to decreased frequency of Ca2+ sparks in a model of heart failure despite enhanced ryanodine receptor activity.

A previously unidentified calcium-dependent mechanism contributes to light adaptation in mammalian rods.

A chimeric ligand–gated channel is activated by the ligands that activate both parent channels, which gate it through two distinct mechanisms.

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