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Jon T. Sack
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Journal Articles

Mechanism of use-dependent Kv2 channel inhibition by RY785

Matthew James Marquis, Jon T. Sack
Journal: Journal of General Physiology
J Gen Physiol (2022) 154 (6): e202112981.
https://doi.org/10.1085/jgp.202112981
Published: 18 April 2022
View articletitled, Mechanism of use-dependent Kv2 channel inhibition by RY785
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Journal Articles

EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues

In Special Collection:
Neuroscience Collection 2022
Parashar Thapa, Robert Stewart, Rebecka J. Sepela, Oscar Vivas, Laxmi K. Parajuli, Mark Lillya, Sebastian Fletcher-Taylor, Bruce E. Cohen, Karen Zito, Jon T. Sack
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (11): e202012858.
https://doi.org/10.1085/jgp.202012858
Published: 28 September 2021
View articletitled, EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues
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Includes: Supplementary data
Journal Articles

Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations

In Special Collection:
Electrical Signaling in the Nervous System and Heart , Ion channel modulation , Structure, Function, and Pharmacology of Ion Channels
Kazuharu Furutani, Kunichika Tsumoto, I-Shan Chen, Kenichiro Handa, Yuko Yamakawa, Jon T. Sack, Yoshihisa Kurachi
Journal: Journal of General Physiology
J Gen Physiol (2019) 151 (2): 214–230.
https://doi.org/10.1085/jgp.201812192
Published: 23 January 2019
View articletitled, Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations
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Includes: Supplementary data
Journal Articles

The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation

In Special Collection:
Electrical Signaling in the Nervous System and Heart , Molecular Basis of Disease and Therapy in the Nervous System , Structure, Function, and Pharmacology of Ion Channels
Drew C. Tilley, Juan M. Angueyra, Kenneth S. Eum, Heesoo Kim, Luke H. Chao, Anthony W. Peng, Jon T. Sack
Journal: Journal of General Physiology
J Gen Physiol (2018) 151 (3): 292–315.
https://doi.org/10.1085/jgp.201812213
Published: 05 November 2018
View articletitled, The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation
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Includes: Supplementary data
Journal Articles

The envenomation of general physiology throughout the last century

In Special Collection:
Celebrating 100 years of JGP
Jon T. Sack
Journal: Journal of General Physiology
Series: JGP 100th Anniversary
J Gen Physiol (2017) 149 (11): 975–983.
https://doi.org/10.1085/jgp.201711856
Published: 11 October 2017
View articletitled, The envenomation of general physiology throughout the last century
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Includes: Supplementary data
Journal Articles

A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization

Isabelle Thiffault, David J. Speca, Daniel C. Austin, Melanie M. Cobb, Kenneth S. Eum, Nicole P. Safina, Lauren Grote, Emily G. Farrow, Neil Miller, Sarah Soden, Stephen F. Kingsmore, James S. Trimmer, Carol J. Saunders, Jon T. Sack
Journal: Journal of General Physiology
J Gen Physiol (2015) 146 (5): 399–410.
https://doi.org/10.1085/jgp.201511444
Published: 26 October 2015
View articletitled, A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization
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Journal Articles

What keeps Kv channels small? The molecular physiology of modesty

Jon T. Sack, Drew C. Tilley
Journal: Journal of General Physiology
J Gen Physiol (2015) 146 (2): 123–127.
https://doi.org/10.1085/jgp.201511469
Published: 27 July 2015
View articletitled, What keeps Kv channels small? The molecular physiology of modesty
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Journal Articles

Antibody-guided photoablation of voltage-gated potassium currents

Jon T. Sack, Nicholas Stephanopoulos, Daniel C. Austin, Matthew B. Francis, James S. Trimmer
Journal: Journal of General Physiology
J Gen Physiol (2013) 142 (3): 315–324.
https://doi.org/10.1085/jgp.201311023
Published: 12 August 2013
View articletitled, Antibody-guided photoablation of voltage-gated potassium currents
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Journal Articles

A SUMO-Phospho tag team for wrestling with potassium channel gating

Danielle Mandikian, Oscar Cerda, Jon T. Sack, James S. Trimmer
Journal: Journal of General Physiology
J Gen Physiol (2011) 137 (5): 435–439.
https://doi.org/10.1085/jgp.201110648
Published: 25 April 2011
View articletitled, A SUMO-Phospho tag team for wrestling with potassium channel gating
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Journal Articles

Arrangement of Kv1 α subunits dictates sensitivity to tetraethylammonium

Ahmed Al-Sabi, Oleg Shamotienko, Sorcha Ni Dhochartaigh, Nagesh Muniyappa, Marie Le Berre, Hamdy Shaban, Jiafu Wang, Jon T. Sack, J. Oliver Dolly
Journal: Journal of General Physiology
J Gen Physiol (2010) 136 (3): 273–282.
https://doi.org/10.1085/jgp.200910398
Published: 30 August 2010
View articletitled, Arrangement of Kv1 α subunits dictates sensitivity to tetraethylammonium
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Journal Articles

How to Validate a Heteromeric Ion Channel Drug Target: Assessing Proper Expression of Concatenated Subunits

Jon T. Sack, Oleg Shamotienko, J. Oliver Dolly
Journal: Journal of General Physiology
J Gen Physiol (2008) 131 (5): 415–420.
https://doi.org/10.1085/jgp.200709939
Published: 14 April 2008
View articletitled, How to Validate a Heteromeric Ion Channel Drug Target: Assessing Proper Expression of Concatenated Subunits
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Journal Articles

Binding of a Gating Modifier Toxin Induces Intersubunit Cooperativity Early in the Shaker K Channel's Activation Pathway

Jon T. Sack, Richard W. Aldrich
Journal: Journal of General Physiology
J Gen Physiol (2006) 128 (1): 119–132.
https://doi.org/10.1085/jgp.200609492
Published: 26 June 2006
View articletitled, Binding of a Gating Modifier Toxin Induces Intersubunit Cooperativity Early in the Shaker K Channel's Activation Pathway
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Journal Articles

A Gastropod Toxin Selectively Slows Early Transitions in the Shaker K Channel's Activation Pathway

Jon T. Sack, Richard W. Aldrich, William F. Gilly
Journal: Journal of General Physiology
J Gen Physiol (2004) 123 (6): 685–696.
https://doi.org/10.1085/jgp.200409047
Published: 17 May 2004
View articletitled, A Gastropod Toxin Selectively Slows Early Transitions in the Shaker K Channel's Activation Pathway
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