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    Cover Image

    issue cover

    Cover picture: Voltage-gated sodium (Nav) channels as targets for animal toxins and therapeutics. For illustrative purposes, NavAb is colored by domain according to a pseudotetrameric arrangement expected for eukaryotic Nav channels. Representative classes of peptide toxins (α, μ, and β), a small molecule toxin (tetrodotoxin [TTX]), as well select small molecule drugs (lidocaine and benzocaine) are represented with arrows pointing to their presumed canonical binding sites and access routes (see Review by Ahern et al., 1–24).

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ISSN 0022-1295
EISSN 1540-7748
In this Issue


Research Articles

Intracellular permeant anions, and not extracellular protons, are the predominant driver of fast gating in the hyperpolarization-activated CLC-2 chloride channel.

A ryanodine receptor 2 mutation associated with catecholaminergic polymorphic ventricular tachycardia renders cardiomyocytes incapable of mediating a positive inotropic response.

¡Vive la différence! In cardiac contraction, the reduction in sarcomere length—rather than length itself—determines contractile force.

Cell-based and modeling studies support a mechanism of passive membrane diffusion for secretion of melatonin from the pineal gland.

Methods and Approaches

KvAP conjugated to beads via a C-terminal His-tag seeds formation of a supported bilayer with unidirectional channel orientation for functional studies.

To improve your calcium estimates, measure zinc!

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