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Research Articles

The pH-sensitive fluorescent protein Venus can be used as an optical reporter for proton flux when fused to an intracellular domain of Hv1 channels.

Researchers have reevaluated the role of calmodulin and previously identified calmodulin binding sites in the mechanism by which Ca2+-release activated Ca2+ channels can be inactivated as Ca2+ ions enter cells.

Researchers examined the role of a domain within the stromal interaction molecule (STIM) in the mechanism by which Ca2+ release–activated Ca2+ channels can be inactivated as Ca2+ ions enter cells.

A chimeric approach combined with extensive site-directed mutagenesis reveals new information about the interaction of the toxin carbenoxolone with the ATP release channel Pannexin1 and the role of the first extracellular loop in channel gating.

Location, location, location. The Na-K pump of skeletal muscle is regulated differently at neuromuscular junctions.

Methods and Approaches

A novel method is presented to measure short distances in cell plasma membranes using transition metal ion FRET with metal ions bound to introduced sites in the membrane.

Transition metal ion FRET between a noncanonical fluorescent amino acid incorporated into TRPV1 and metal ions bound to the cell plasma can be used to measure distances and dynamics between cytosolic domains of proteins and the membrane.

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