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Cover Image
Cover Image
Cover picture: Entrance to the pore of a potassium channel, as viewed by a cytosolic K+ ion. The yellow and blue circles, respectively, demarcate the largest and smallest effective pore-opening size. Potassium ions in the selectivity filter are indicated in pink, and proline 475 atoms at the inner mouth of the pore are indicated in red (O), blue (N), and teal (C) (see research article by Díaz-Franulic et al., 133–146).
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Generally Physiological
Commentary
Article
Pore dimensions and the role of occupancy in unitary conductance of Shaker K channels
The resistance of the inner vestibule limits Shaker’s conductance.
Proton block of proton-activated TRPV1 current
H+ not only activates the TRPV1 cation channel but inhibits ion permeation, yielding a prominent OFF current response.
Sphingomyelinase D inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current
Sphingomyelinase D suppresses Orai current in human T cells and decreases cytokine production, providing a mechanism whereby certain bacteria could inhibit the immune system.
A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc
Zinc and ifenprodil induce similar conformational changes in the NMDA receptor, suggesting a conserved mechanism of inhibition independent of receptor subtype and the site at which the inhibitor binds.
Ion selectivity of the anthrax toxin channel and its effect on protein translocation
Macroscopic cation selectivity fails to predict protein translocation through the anthrax toxin channel.
