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Issues

Generally Physiological

Commentary

Research Articles

The resistance of the inner vestibule limits Shaker’s conductance.

H+ not only activates the TRPV1 cation channel but inhibits ion permeation, yielding a prominent OFF current response.

Sphingomyelinase D suppresses Orai current in human T cells and decreases cytokine production, providing a mechanism whereby certain bacteria could inhibit the immune system.

Zinc and ifenprodil induce similar conformational changes in the NMDA receptor, suggesting a conserved mechanism of inhibition independent of receptor subtype and the site at which the inhibitor binds.

Macroscopic cation selectivity fails to predict protein translocation through the anthrax toxin channel.

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