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Cover Image
Cover Image
Cover picture: A 3-D projection of a single isolated goldfish retinal bipolar cell stained with the live-cell microtubule dye SiR-tubulin. The color spectrum represents depth. Microtubules can be seen to extend from the tips of the dendrites (top) into the axon and down into the giant synaptic terminal (bottom). A loop of microtubules encircles the inner plasma membrane of the terminal and anchors mitochondria (see Communication by Graffe et al., 109–117).
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Generally Physiological
Review
Article
The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold
Functional analyses of ELIC raise the intriguing possibility that this bacterial channel may represent a previously unrecognized branch of the superfamily of pentameric ligand-gated ion channels with markedly divergent pore properties.
Comparative sequence analysis suggests a conserved gating mechanism for TRP channels
Comparative sequence analysis indicates that a common mechanism underlying polymodal gating of TRP channels involves the relaxation of a structural distortion of pore-lining helices.
Regulation of the transient receptor potential channel TRPM3 by phosphoinositides
TRPM3 is dynamically regulated by plasma membrane PI(4,5)P2 and related PIPs.
Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel
PI(4,5)P2 is required for TRPM3 activity, establishing its role as a crucial cofactor for the entire TRPM channel family.
Membrane potential and Ca2+ concentration dependence on pressure and vasoactive agents in arterial smooth muscle: A model
A mathematical model incorporating junctional and stretch-activated microdomains and 37 protein components describes the myogenic response in arterial smooth muscle cells.
Rem uncouples excitation–contraction coupling in adult skeletal muscle fibers
The RGK protein Rem uncouples the voltage sensors of CaV1.1 from RYR1-mediated sarcoplasmic reticulum Ca2+ release via its ability to interact with the auxiliary β1a subunit.
Communication
A marginal band of microtubules transports and organizes mitochondria in retinal bipolar synaptic terminals
A band of microtubules ringing the retinal bipolar cell synaptic terminal may be crucial to supply and anchor the mitochondria required to sustain transmitter release.
