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Issues

Generally Physiological

Review

Research Articles

Functional analyses of ELIC raise the intriguing possibility that this bacterial channel may represent a previously unrecognized branch of the superfamily of pentameric ligand-gated ion channels with markedly divergent pore properties.

Comparative sequence analysis indicates that a common mechanism underlying polymodal gating of TRP channels involves the relaxation of a structural distortion of pore-lining helices.

TRPM3 is dynamically regulated by plasma membrane PI(4,5)P2 and related PIPs.

PI(4,5)P2 is required for TRPM3 activity, establishing its role as a crucial cofactor for the entire TRPM channel family.

A mathematical model incorporating junctional and stretch-activated microdomains and 37 protein components describes the myogenic response in arterial smooth muscle cells.

The RGK protein Rem uncouples the voltage sensors of CaV1.1 from RYR1-mediated sarcoplasmic reticulum Ca2+ release via its ability to interact with the auxiliary β1a subunit.

Communication

A band of microtubules ringing the retinal bipolar cell synaptic terminal may be crucial to supply and anchor the mitochondria required to sustain transmitter release.

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