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    Cover picture: The couplon, a set of linked proteins, controls contraction of striated muscles via cytosolic release of calcium. In skeletal muscle, it comprises tetrads of voltage sensors in the membrane of transverse tubules (blue), calcium release channels in the sarcoplasmic reticulum membrane, calcium-storing calsequestrin polymers inside the SR, and various small connecting molecules (represented, from left to right, are JP-45, junctin, and triadin; see Viewpoint by Ríos et al., 459–474). Image by Heather B. McDonald.

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ISSN 0022-1295
EISSN 1540-7748

Generally Physiological

Viewpoint

Commentary

Research Articles

Calcium waves can form and propagate at low frequencies of spontaneous calcium sparks if the calcium dependence of spark frequency is sufficiently steep, or the number of open RyRs is sufficiently large.

Results from single-molecule and macroscopic electrophysiology and kinetic analysis provide a model for activation of the glutamate-bound NMDA receptor by glycine.

Membrane targeting of the β2e subunit is dynamically regulated by M1 muscarinic receptor signaling to promote fast inactivation of CaV2.2.

The marked difference in the efficacy of BKγ subunits in shifting the voltage dependence of BK activation depends mainly on the TM segment and a neighboring intracellular cluster of positively charged amino acids.

Methods and Approaches

A novel approach to analyzing binding data from proteins with two binding sites for the same substrate provides information beyond that accessible with traditional Hill equation analysis.

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