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Cover Image
Cover Image
Cover picture: The couplon, a set of linked proteins, controls contraction of striated muscles via cytosolic release of calcium. In skeletal muscle, it comprises tetrads of voltage sensors in the membrane of transverse tubules (blue), calcium release channels in the sarcoplasmic reticulum membrane, calcium-storing calsequestrin polymers inside the SR, and various small connecting molecules (represented, from left to right, are JP-45, junctin, and triadin; see Viewpoint by Ríos et al., 459–474). Image by Heather B. McDonald.
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Generally Physiological
Viewpoint
Commentary
Article
Ryanodine receptor gating controls generation of diastolic calcium waves in cardiac myocytes
Calcium waves can form and propagate at low frequencies of spontaneous calcium sparks if the calcium dependence of spark frequency is sufficiently steep, or the number of open RyRs is sufficiently large.
Glycine-dependent activation of NMDA receptors
Results from single-molecule and macroscopic electrophysiology and kinetic analysis provide a model for activation of the glutamate-bound NMDA receptor by glycine.
Dynamic phospholipid interaction of β2e subunit regulates the gating of voltage-gated Ca2+ channels
Membrane targeting of the β2e subunit is dynamically regulated by M1 muscarinic receptor signaling to promote fast inactivation of CaV2.2.
Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits
The marked difference in the efficacy of BKγ subunits in shifting the voltage dependence of BK activation depends mainly on the TM segment and a neighboring intracellular cluster of positively charged amino acids.
Methods and Approaches
Beyond non-integer Hill coefficients: A novel approach to analyzing binding data, applied to Na+-driven transporters
A novel approach to analyzing binding data from proteins with two binding sites for the same substrate provides information beyond that accessible with traditional Hill equation analysis.
