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Journal Articles

Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy

John H. Lewis, Yufeng Zhou, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413709.
https://doi.org/10.1085/jgp.202413709
Published: 20 February 2025
View articletitled, Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy
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Includes: Supplementary data
Journal Articles

A novel high-affinity inhibitor against the human ATP-sensitive Kir6.2 channel

Yajamana Ramu, Yanping Xu, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2018) 150 (7): 969–976.
https://doi.org/10.1085/jgp.201812017
Published: 29 May 2018
View articletitled, A novel high-affinity inhibitor against the human ATP-sensitive Kir6.2 channel
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Journal Articles

Sphingomyelinase D inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current

David J. Combs, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2015) 146 (2): 161–172.
https://doi.org/10.1085/jgp.201511359
Published: 27 July 2015
View articletitled, Sphingomyelinase D inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current
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Journal Articles

Tuning voltage-gated channel activity and cellular excitability with a sphingomyelinase

David J. Combs, Hyeon-Gyu Shin, Yanping Xu, Yajamana Ramu, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2013) 142 (4): 367–380.
https://doi.org/10.1085/jgp.201310986
Published: 16 September 2013
View articletitled, Tuning voltage-gated channel activity and cellular excitability with a sphingomyelinase
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Journal Articles

Extracellular protons titrate voltage gating of a ligand-gated ion channel

Juan Ramón Martínez-François, Yanping Xu, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2010) 136 (2): 179–187.
https://doi.org/10.1085/jgp.201010444
Published: 12 July 2010
View articletitled, Extracellular protons titrate voltage gating of a ligand-gated ion channel
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Journal Articles

Intrinsic versus extrinsic voltage sensitivity of blocker interaction with an ion channel pore

Juan Ramón Martínez-François, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2010) 135 (2): 149–167.
https://doi.org/10.1085/jgp.200910324
Published: 25 January 2010
View articletitled, Intrinsic versus extrinsic voltage sensitivity of blocker interaction with an ion channel pore
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Journal Articles

Mutations reveal voltage gating of CNGA1 channels in saturating cGMP

Juan Ramón Martínez-François, Yanping Xu, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2009) 134 (2): 151–164.
https://doi.org/10.1085/jgp.200910240
Published: 27 July 2009
View articletitled, Mutations reveal voltage gating of CNGA1 channels in saturating cGMP
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Includes: Supplementary data
Journal Articles

Evidence for Sequential Ion-binding Loci along the Inner Pore of the IRK1 Inward-rectifier K+ Channel

Hyeon-Gyu Shin, Yanping Xu, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2005) 126 (2): 123–135.
https://doi.org/10.1085/jgp.200509296
Published: 25 July 2005
View articletitled, Evidence for Sequential Ion-binding Loci along the Inner Pore of the IRK1 Inward-rectifier K+ Channel
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Journal Articles

Mechanism of the Voltage Sensitivity of IRK1 Inward-rectifier K+ Channel Block by the Polyamine Spermine

Hyeon-Gyu Shin, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2005) 125 (4): 413–426.
https://doi.org/10.1085/jgp.200409242
Published: 14 March 2005
View articletitled, Mechanism of the Voltage Sensitivity of IRK1 Inward-rectifier K+ Channel Block by the Polyamine Spermine
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Journal Articles

Interaction Mechanisms between Polyamines and IRK1 Inward Rectifier K+ Channels

Donglin Guo, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2003) 122 (5): 485–500.
https://doi.org/10.1085/jgp.200308890
Published: 27 October 2003
View articletitled, Interaction Mechanisms between Polyamines and IRK1 Inward Rectifier K+ Channels
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Journal Articles

Mechanism of Rectification in Inward-rectifier K+ Channels

Donglin Guo, Yajamana Ramu, Angela M. Klem, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2003) 121 (4): 261–276.
https://doi.org/10.1085/jgp.200208771
Published: 17 March 2003
View articletitled, Mechanism of Rectification in Inward-rectifier K+ Channels
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Journal Articles

Coupling between Voltage Sensors and Activation Gate in Voltage-gated K+ Channels

Zhe Lu, Angela M. Klem, Yajamana Ramu
Journal: Journal of General Physiology
J Gen Physiol (2002) 120 (5): 663–676.
https://doi.org/10.1085/jgp.20028696
Published: 29 October 2002
View articletitled, Coupling between Voltage Sensors and Activation Gate in Voltage-gated K+ Channels
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Journal Articles

IRK1 Inward Rectifier K+ Channels Exhibit No Intrinsic Rectification

Donglin Guo, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2002) 120 (4): 539–551.
https://doi.org/10.1085/jgp.20028623
Published: 16 September 2002
View articletitled, IRK1 Inward Rectifier K+ Channels Exhibit No Intrinsic Rectification
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Journal Articles

Kinetics of Inward-Rectifier K+ Channel Block by Quaternary Alkylammonium Ions: Dimension and Properties of the Inner Pore

Donglin Guo, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2001) 117 (5): 395–406.
https://doi.org/10.1085/jgp.117.5.395
Published: 16 April 2001
View articletitled, Kinetics of Inward-Rectifier K+ Channel Block by Quaternary Alkylammonium Ions: Dimension and Properties of the Inner Pore
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Journal Articles

Pore Block versus Intrinsic Gating in the Mechanism of Inward Rectification in Strongly Rectifying Irk1 Channels

Donglin Guo, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2000) 116 (4): 561–568.
https://doi.org/10.1085/jgp.116.4.561
Published: 25 September 2000
View articletitled, Pore Block versus Intrinsic Gating in the Mechanism of Inward Rectification in Strongly Rectifying Irk1 Channels
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Journal Articles

Mechanism of Irk1 Channel Block by Intracellular Polyamines

Donglin Guo, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2000) 115 (6): 799–814.
https://doi.org/10.1085/jgp.115.6.799
Published: 01 June 2000
View articletitled, Mechanism of Irk1 Channel Block by Intracellular Polyamines
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Journal Articles

Mechanism of Cgmp-Gated Channel Block by Intracellular Polyamines

Donglin Guo, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2000) 115 (6): 783–798.
https://doi.org/10.1085/jgp.115.6.783
Published: 01 June 2000
View articletitled, Mechanism of Cgmp-Gated Channel Block by Intracellular Polyamines
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Journal Articles

Tuning the Voltage Dependence of Tetraethylammonium Block with Permeant Ions in an Inward-Rectifier K+ Channel

Maria Spassova, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (1999) 114 (3): 415–426.
https://doi.org/10.1085/jgp.114.3.415
Published: 01 September 1999
View articletitled, Tuning the Voltage Dependence of Tetraethylammonium Block with Permeant Ions in an Inward-Rectifier K+ Channel
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Journal Articles

Blockade of a Retinal cGMP-gated Channel by Polyamines

Zhe Lu, Long Ding
Journal: Journal of General Physiology
J Gen Physiol (1999) 113 (1): 35–43.
https://doi.org/10.1085/jgp.113.1.35
Published: 01 January 1999
View articletitled, Blockade of a Retinal cGMP-gated Channel by Polyamines
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Journal Articles

Coupled Ion Movement Underlies Rectification in an Inward-Rectifier K+ Channel

Maria Spassova, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (1998) 112 (2): 211–221.
https://doi.org/10.1085/jgp.112.2.211
Published: 01 August 1998
View articletitled, Coupled Ion Movement Underlies Rectification in an Inward-Rectifier K+ Channel
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