Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity
Chromaffin cells from mice lacking the BK β2 subunit show decreased action potential firing during current injection but an increase in spontaneous burst firing.
The pathogenic G551D mutation of CFTR converts one of the two ATP-binding sites from excitatory to inhibitory.
Structure–activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects
The head and tail regions of 5-nitro-2-(3-phenylpropylamino)benzoate increase CFTR open probability through distinct mechanisms.
Residues forming interfaces between the three ENaC subunits participate in conformational changes required for transition between open and closed states.