Issues

Cover picture: Accessibility to trypsin digestion of BK channel β-subunit N termini reveals their sequestration in the channel antechamber. (Top) Schematic of the pathway for access of the β2 N-terminal inactivation domain to the BK channel central cavity. (Bottom) Model of the hypothesis that N termini transiently bind in the antechamber between the pore and cytosolic domains, resulting in reduced rates of trypsin digestion even in closed channels (see article by Zhang et al., 263–282).