Issues

Cover picture: TRPM2 closure is slowed by extracellular Ca²⁺ entry through the channel pore. (Left) Current decay upon rapid removal of intracellular Ca²⁺ is much slower when extracellular Ca²⁺ is high. (Right) Interpretation. (Top) Without extracellular Ca²⁺, the activating sites rapidly lose Ca²⁺ and quickly close. (Bottom) In high extracellular Ca²⁺, the activating sites, located in a deep vestibule of the channel, remain liganded longer due to Ca²⁺ entry through the open pore (see article by Csanády and Törőcsik, 189 – 203).