Issues
1 February 2009
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Cover Image
Cover Image
Cover picture: TRPM2 closure is slowed by extracellular Ca2+ entry through the channel pore. (Left) Current decay upon rapid removal of intracellular Ca2+ is much slower when extracellular Ca2+ is high. (Right) Interpretation. (Top) Without extracellular Ca2+, the activating sites rapidly lose Ca2+ and quickly close. (Bottom) In high extracellular Ca2+, the activating sites, located in a deep vestibule of the channel, remain liganded longer due to Ca2+ entry through the open pore (see article by Csanády and Törőcsik, 189 – 203).
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ISSN 0022-1295
EISSN 1540-7748
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