Issues

Cover picture: Fluorescence changes reveal rapid interactions between muscarinic receptor (M₁R) and G proteins during receptor activation. (Top) Cartoon of expressed proteins in membrane: fluorescently labeled M₁R-CFP and Gβ₁-YFP and unlabeled Gα_q and Gγ₂. (Middle) Kinetics of M₁R/Gβ1 interaction in a single cell. Blue and orange lines are fluorescence from M₁R-CFP and Gβ₁-YFP and the black line is their ratio. (Bottom) Averaged FRET timecourse from several cells (see article by Jensen et al., 347–359).