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Journal Articles

The partitioning of TCR repertoires by thymic selection

Wan-Lin Lo, Eric S. Huseby

J Exp Med (2024) 221 (10): e20230897.

https://doi.org/10.1084/jem.20230897

Published: 21 August 2024

View article titled, The partitioning of TCR repertoires by thymic selection

Journal Articles

B cell tolerance and autoimmunity: Lessons from repertoires

Jacques Deguine, Ramnik J. Xavier

J Exp Med (2024) 221 (9): e20231314.

https://doi.org/10.1084/jem.20231314

Published: 02 August 2024

View article titled, B cell tolerance and autoimmunity: Lessons from repertoires

Journal Articles

Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development

Isabel Baldwin, Ellen A. Robey

J Exp Med (2024) 221 (10): e20230896.

https://doi.org/10.1084/jem.20230896

Published: 09 July 2024

View article titled, Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development

Journal Articles

Generation and repair of thymic epithelial cells

Graham Anderson, Emilie J. Cosway, Kieran D. James, Izumi Ohigashi, Yousuke Takahama

J Exp Med (2024) 221 (10): e20230894.

https://doi.org/10.1084/jem.20230894

Published: 09 July 2024

View article titled, Generation and repair of thymic epithelial cells

Journal Articles

Dynamic Foxp3–chromatin interaction controls tunable Treg cell function

Minghong He, Xinying Zong, Beisi Xu, Wenjie Qi, Wenjun Huang, Mohamed Nadhir Djekidel, Yang Zhang, Vishwajeeth R. Pagala, Jun Li, Xiaolei Hao, Clifford Guy, Lu Bai, Richard Cross, Chunliang Li, Junmin Peng, Yongqiang Feng

J Exp Med (2024) 221 (9): e20232068.

https://doi.org/10.1084/jem.20232068

Published: 27 June 2024

View article titled, Dynamic Foxp3–chromatin interaction controls tunable Treg cell function

Includes: Supplementary data

Journal Articles

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity

In Special Collection:

JEM Immunology Collection 2024

J Exp Med (2024) 221 (4): e20221080.

https://doi.org/10.1084/jem.20221080

Published: 28 February 2024

View article titled, Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity

Includes: Supplementary data

Journal Articles

Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance

In Special Collection:

Lymphatic Vessels in Health and Disease 2024

Hyunjung Min, Shane M. O’Neil, Li Xu, E. Ashley Moseman, Joanne Kurtzberg, Anthony J. Filiano

J Exp Med (2024) 221 (2): e20230326.

https://doi.org/10.1084/jem.20230326

Published: 09 January 2024

View article titled, Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance

Includes: Supplementary data

Journal Articles

Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes

In Special Collection:

Barrier Immunity , Immunology Update Winter 2024

J Exp Med (2023) 221 (1): e20230930.

https://doi.org/10.1084/jem.20230930

Published: 13 December 2023

View article titled, Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes

Includes: Supplementary data

Journal Articles

Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice

In Special Collection:

JEM Immunology Collection 2024 , Innate Immune Signaling: From Host Defense to Disease Pathogenesis

Adriana Vasquez Ayala, Chia-Yun Hsu, Renee E. Oles, Kazuhiko Matsuo, Luke R. Loomis, Ekaterina Buzun, Marvic Carrillo Terrazas, Romana R. Gerner, Hsueh-Han Lu, Sohee Kim, Ziyue Zhang, Jong Hwee Park, Paul Rivaud, Matt Thomson, Li-Fan Lu, Booki Min, Hiutung Chu

J Exp Med (2023) 221 (1): e20230063.

https://doi.org/10.1084/jem.20230063

Published: 12 December 2023

View article titled, Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice

Journal Articles

First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Thymus, T Cell Development, and Inborn Errors , 2023: The Year in Experimental Medicine

Esther Bernaldo-de-Quirós, Manuela Camino, Marta Martínez-Bonet, Juan Miguel Gil-Jaurena, Nuria Gil, Diana Hernández-Flórez, Maria Eugenia Fernández-Santos, Laura Butragueño, I. Esmé Dijke, Megan K. Levings, Lori J. West, Marjorie Pion, Rafael Correa-Rocha

J Exp Med (2023) 220 (12): e20231045.

https://doi.org/10.1084/jem.20231045

Published: 31 October 2023

View article titled, First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant

Journal Articles

BATF represses BIM to sustain tolerant T cells in the periphery

Philip J. Titcombe, Milagros Silva Morales, Na Zhang, Daniel L. Mueller

J Exp Med (2023) 220 (12): e20230183.

https://doi.org/10.1084/jem.20230183

Published: 20 October 2023

View article titled, BATF represses BIM to sustain tolerant T cells in the periphery

Includes: Supplementary data

Journal Articles

The CD4⁺ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance

In Special Collection:

Thymus, T Cell Development, and Inborn Errors

Matthew K. McElwee, Thamotharampillai Dileepan, Shawn A. Mahmud, Marc K. Jenkins

J Exp Med (2023) 220 (12): e20230209.

https://doi.org/10.1084/jem.20230209

Published: 13 October 2023

View article titled, The CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance

Includes: Supplementary data

Journal Articles

Tregs tame skin bacteria and IFN-γ–associated pathology

Michail S. Lionakis

J Exp Med (2023) 220 (12): e20231571.

https://doi.org/10.1084/jem.20231571

Published: 10 October 2023

View article titled, Tregs tame skin bacteria and IFN-γ–associated pathology

Journal Articles

Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice

J Exp Med (2023) 220 (11): e20230101.

https://doi.org/10.1084/jem.20230101

Published: 11 September 2023

View article titled, Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice

Journal Articles

Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis

Sreeparna Chakraborty, Abhalaxmi Singh, Li Wang, Xinge Wang, Mark A. Sanborn, Zijing Ye, Mark Maienschein-Cline, Amitabha Mukhopadhyay, Balaji B. Ganesh, Asrar B. Malik, Jalees Rehman

J Exp Med (2023) 220 (11): e20221388.

https://doi.org/10.1084/jem.20221388

Published: 24 August 2023

View article titled, Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis

Includes: Supplementary data

Journal Articles

miR-15/16 clusters restrict effector Treg cell differentiation and function

Jiayi Dong, William J. Huth, Nimi Marcel, Ziyue Zhang, Ling-Li Lin, Li-Fan Lu

J Exp Med (2023) 220 (10): e20230321.

https://doi.org/10.1084/jem.20230321

Published: 27 July 2023

View article titled, miR-15/16 clusters restrict effector Treg cell differentiation and function

Includes: Supplementary data

Journal Articles

Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice

Jenna L. Collier, Kristen E. Pauken, Catherine A.A. Lee, Dillon G. Patterson, Samuel C. Markson, Thomas S. Conway, Megan E. Fung, Joshua A. France, Kyla N. Mucciarone, Christine G. Lian, George F. Murphy, Arlene H. Sharpe

J Exp Med (2023) 220 (10): e20221920.

https://doi.org/10.1084/jem.20221920

Published: 11 July 2023

View article titled, Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice

Includes: Supplementary data

Journal Articles

Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus

In Special Collection:

Thymus, T Cell Development, and Inborn Errors

Daniel A. Michelson, Chong Zuo, Michael Verzi, Christophe Benoist, Diane Mathis

J Exp Med (2023) 220 (10): e20230461.

https://doi.org/10.1084/jem.20230461

Published: 03 July 2023

View article titled, Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus

Includes: Supplementary data

Journal Articles

Dietary protein shapes the profile and repertoire of intestinal CD4⁺ T cells

In Special Collection:

Barrier Immunity , Microbiota, Diet, Metabolites and the Immune System 2023 , 2023: The Year in Experimental Medicine

Ainsley Lockhart, Aubrey Reed, Tiago Rezende de Castro, Calvin Herman, Maria Cecilia Campos Canesso, Daniel Mucida

J Exp Med (2023) 220 (8): e20221816.

https://doi.org/10.1084/jem.20221816

Published: 16 May 2023

View article titled, Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells

Includes: Supplementary data

Journal Articles

Identification of an anergic B_ND cell–derived activated B cell population (B_ND2) in young-onset type 1 diabetes patients

In Special Collection:

Autoimmunity: From Novel Mechanisms to Treatments , B cells, Infectious Diseases, and Autoimmunity , JEM Clinical Immunology Collection 2023

Zachary C. Stensland, Christopher A. Magera, Hali Broncucia, Brittany D. Gomez, Nasha M. Rios-Guzman, Kristen L. Wells, Catherine A. Nicholas, Marynette Rihanek, Maya J. Hunter, Kevin P. Toole, Peter A. Gottlieb, Mia J. Smith

J Exp Med (2023) 220 (8): e20221604.

https://doi.org/10.1084/jem.20221604

Published: 15 May 2023

View article titled, Identification of an anergic BND cell–derived activated B cell population (BND2) in young-onset type 1 diabetes patients

Includes: Supplementary data

NARROW

The partitioning of TCR repertoires by thymic selection

B cell tolerance and autoimmunity: Lessons from repertoires

Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development

Generation and repair of thymic epithelial cells

Dynamic Foxp3–chromatin interaction controls tunable Treg cell function

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity

Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance

Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes

Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice

First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant

BATF represses BIM to sustain tolerant T cells in the periphery

The CD4⁺ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance

Tregs tame skin bacteria and IFN-γ–associated pathology

Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice

Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis

miR-15/16 clusters restrict effector Treg cell differentiation and function

Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice

Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus

Dietary protein shapes the profile and repertoire of intestinal CD4⁺ T cells

Identification of an anergic B_ND cell–derived activated B cell population (B_ND2) in young-onset type 1 diabetes patients

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