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Journal Articles

“What’s in a name?” Clarifying the identity of RORγt+ antigen-presenting cells

Feiya Ou, Kenneth M. Murphy
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250760.
https://doi.org/10.1084/jem.20250760
Published: 15 May 2025
View articletitled, “What’s in a name?” Clarifying the identity of RORγt+ antigen-presenting cells
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Journal Articles

Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα

Artur Stoljar, Maksym Zarodniuk, Rudolf Bichele, Elise Helene Armulik, Uku Haljasorg, Romain Humeau, Marine Besnard, Liis Haljasmägi, Liina Tserel, Merili Peltser, Ahto Salumets, Eliisa Kekäläinen, Kai Kisand, Carole Guillonneau, Martti Laan, Pärt Peterson
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241403.
https://doi.org/10.1084/jem.20241403
Published: 30 April 2025
View articletitled, Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα
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Includes: Supplementary data
Journal Articles

RORγt eTACs mediate oral tolerance and Treg induction

Im-Hong Sun, Anita E. Qualls, Han S. Yin, Jiaxi Wang, Matthew P. Arvedson, Joe Germino, Nolan K. Horner, Sheng Zhong, Juan Du, Martin Valdearcos, Vasilis Ntranos, Richard M. Locksley, Roberto R. Ricardo-Gonzalez, James M. Gardner
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250573.
https://doi.org/10.1084/jem.20250573
Published: 29 April 2025
View articletitled, RORγt eTACs mediate oral tolerance and Treg induction
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Includes: Supplementary data
Journal Articles

Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus

Minoru Matsumoto, Masaki Yoshida, Takeshi Oya, Koichi Tsuneyama, Mitsuru Matsumoto, Hideyuki Yoshida
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20240817.
https://doi.org/10.1084/jem.20240817
Published: 17 April 2025
View articletitled, Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus
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Includes: Supplementary data
Journal Articles

Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection

Diana Muñoz Sandoval, Florian A. Bach, Alasdair Ivens, Adam C. Harding, Natasha L. Smith, Michalina Mazurczyk, Yrene Themistocleous, Nick J. Edwards, Sarah E. Silk, Jordan R. Barrett, Graeme J.M. Cowan, Giorgio Napolitani, Nicholas J. Savill, Simon J. Draper, Angela M. Minassian, Wiebke Nahrendorf, Philip J. Spence
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241667.
https://doi.org/10.1084/jem.20241667
Published: 11 April 2025
View articletitled, Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection
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Includes: Supplementary data
Journal Articles

CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy

Sirimuvva Tadepalli, Derek R. Clements, Hayley M. Raquer-McKay, Anja Lüdtke, Sanjana Saravanan, David Seong, Lorraine Vitek, Christopher M. Richards, Jan E. Carette, Matthias Mack, Andres Gottfried-Blackmore, Edward E. Graves, Juliana Idoyaga
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20231717.
https://doi.org/10.1084/jem.20231717
Published: 27 March 2025
View articletitled, CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy
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Includes: Supplementary data
Journal Articles

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer

In Special Collection:
JEM Immunology Collection 2025
Simon J. Cleary, Longhui Qiu, Yurim Seo, Peter Baluk, Dan Liu, Nina K. Serwas, Catherine A. Taylor, Dongliang Zhang, Jason G. Cyster, Donald M. McDonald, Matthew F. Krummel, Mark R. Looney
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241359.
https://doi.org/10.1084/jem.20241359
Published: 19 February 2025
View articletitled, Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer
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Includes: Supplementary data
Journal Articles

Finding NEMO in the thymus

Juan Moises Ocampo-Godinez, Alexandra Y. Kreins
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20241590.
https://doi.org/10.1084/jem.20241590
Published: 21 October 2024
View articletitled, Finding NEMO in the thymus
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Journal Articles

The partitioning of TCR repertoires by thymic selection

In Special Collection:
Autoimmunity 2024
Wan-Lin Lo, Eric S. Huseby
Journal: Journal of Experimental Medicine
Series: Thymus and T Cell Development Focus
J Exp Med (2024) 221 (10): e20230897.
https://doi.org/10.1084/jem.20230897
Published: 21 August 2024
View articletitled, The partitioning of TCR repertoires by thymic selection
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Journal Articles

B cell tolerance and autoimmunity: Lessons from repertoires

In Special Collection:
JEM Immunology Collection 2025 , Autoimmunity 2024 , Immunity Review Series
Jacques Deguine, Ramnik J. Xavier
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20231314.
https://doi.org/10.1084/jem.20231314
Published: 02 August 2024
View articletitled, B cell tolerance and autoimmunity: Lessons from repertoires
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Journal Articles

Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development

In Special Collection:
Autoimmunity 2024
Isabel Baldwin, Ellen A. Robey
Journal: Journal of Experimental Medicine
Series: Thymus and T Cell Development Focus
J Exp Med (2024) 221 (10): e20230896.
https://doi.org/10.1084/jem.20230896
Published: 09 July 2024
View articletitled, Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development
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Journal Articles

Generation and repair of thymic epithelial cells

In Special Collection:
Autoimmunity 2024 , Immunology Update Winter 2025
Graham Anderson, Emilie J. Cosway, Kieran D. James, Izumi Ohigashi, Yousuke Takahama
Journal: Journal of Experimental Medicine
Series: Thymus and T Cell Development Focus
J Exp Med (2024) 221 (10): e20230894.
https://doi.org/10.1084/jem.20230894
Published: 09 July 2024
View articletitled, Generation and repair of thymic epithelial cells
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Journal Articles

Dynamic Foxp3–chromatin interaction controls tunable Treg cell function

In Special Collection:
Autoimmunity 2024
Minghong He, Xinying Zong, Beisi Xu, Wenjie Qi, Wenjun Huang, Mohamed Nadhir Djekidel, Yang Zhang, Vishwajeeth R. Pagala, Jun Li, Xiaolei Hao, Clifford Guy, Lu Bai, Richard Cross, Chunliang Li, Junmin Peng, Yongqiang Feng
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20232068.
https://doi.org/10.1084/jem.20232068
Published: 27 June 2024
View articletitled, Dynamic Foxp3–chromatin interaction controls tunable Treg cell function
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Includes: Supplementary data
Journal Articles

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity

In Special Collection:
Autoimmunity 2024 , JEM Immunology Collection 2024
Yaoyuan Zhang, Rhiannon Morris, Grant J. Brown, Ayla May D. Lorenzo, Xiangpeng Meng, Nadia J. Kershaw, Pamudika Kiridena, Gaétan Burgio, Simon Gross, Jean Y. Cappello, Qian Shen, Hao Wang, Cynthia Turnbull, Tom Lea-Henry, Maurice Stanley, Zhijia Yu, Fiona D. Ballard, Aaron Chuah, James C. Lee, Ann-Maree Hatch, Anselm Enders, Seth L. Masters, Alexander P. Headley, Peter Trnka, Dominic Mallon, Jeffery T. Fletcher, Giles D. Walters, Mario Šestan, Marija Jelušić, Matthew C. Cook, Vicki Athanasopoulos, David A. Fulcher, Jeffrey J. Babon, Carola G. Vinuesa, Julia I. Ellyard
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20221080.
https://doi.org/10.1084/jem.20221080
Published: 28 February 2024
View articletitled, Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity
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Includes: Supplementary data
Journal Articles

Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance

In Special Collection:
Autoimmunity 2024 , Lymphatic Vessels in Health and Disease 2024 , Neuroscience Collection 2024
Hyunjung Min, Shane M. O’Neil, Li Xu, E. Ashley Moseman, Joanne Kurtzberg, Anthony J. Filiano
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (2): e20230326.
https://doi.org/10.1084/jem.20230326
Published: 09 January 2024
View articletitled, Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance
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Includes: Supplementary data
Journal Articles

Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes

In Special Collection:
Barrier Immunity , Immunology Update Winter 2024
Jianing Fu, Zicheng Wang, Mercedes Martinez, Aleksandar Obradovic, Wenyu Jiao, Kristjana Frangaj, Rebecca Jones, Xinzheng V. Guo, Ya Zhang, Wan-I Kuo, Huaibin M. Ko, Alina Iuga, Constanza Bay Muntnich, Adriana Prada Rey, Kortney Rogers, Julien Zuber, Wenji Ma, Michelle Miron, Donna L. Farber, Joshua Weiner, Tomoaki Kato, Yufeng Shen, Megan Sykes
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (1): e20230930.
https://doi.org/10.1084/jem.20230930
Published: 13 December 2023
View articletitled, Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes
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Includes: Supplementary data
Journal Articles

Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice

In Special Collection:
JEM Immunology Collection 2024 , Innate Immune Signaling: From Host Defense to Disease Pathogenesis
Adriana Vasquez Ayala, Chia-Yun Hsu, Renee E. Oles, Kazuhiko Matsuo, Luke R. Loomis, Ekaterina Buzun, Marvic Carrillo Terrazas, Romana R. Gerner, Hsueh-Han Lu, Sohee Kim, Ziyue Zhang, Jong Hwee Park, Paul Rivaud, Matt Thomson, Li-Fan Lu, Booki Min, Hiutung Chu
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (1): e20230063.
https://doi.org/10.1084/jem.20230063
Published: 12 December 2023
View articletitled, Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice
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Journal Articles

First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant

In Special Collection:
Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Thymus, T Cell Development, and Inborn Errors , 2023: The Year in Experimental Medicine
Esther Bernaldo-de-Quirós, Manuela Camino, Marta Martínez-Bonet, Juan Miguel Gil-Jaurena, Nuria Gil, Diana Hernández-Flórez, Maria Eugenia Fernández-Santos, Laura Butragueño, I. Esmé Dijke, Megan K. Levings, Lori J. West, Marjorie Pion, Rafael Correa-Rocha
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (12): e20231045.
https://doi.org/10.1084/jem.20231045
Published: 31 October 2023
View articletitled, First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant
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Journal Articles

BATF represses BIM to sustain tolerant T cells in the periphery

Philip J. Titcombe, Milagros Silva Morales, Na Zhang, Daniel L. Mueller
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (12): e20230183.
https://doi.org/10.1084/jem.20230183
Published: 20 October 2023
View articletitled, BATF represses BIM to sustain tolerant T cells in the periphery
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Includes: Supplementary data
Journal Articles

The CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance

In Special Collection:
Thymus, T Cell Development, and Inborn Errors
Matthew K. McElwee, Thamotharampillai Dileepan, Shawn A. Mahmud, Marc K. Jenkins
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (12): e20230209.
https://doi.org/10.1084/jem.20230209
Published: 13 October 2023
View articletitled, The CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance
Open the PDF for The CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance in another window
Includes: Supplementary data