1-20 of 92
Tolerance
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells

Matouš Vobořil, Fernando Bandeira Sulczewski, Ryan J. Martinez, K. Maude Ashby, Michael Manoharan Valerio, Juliana Idoyaga, Kristin A. Hogquist
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20250733.
https://doi.org/10.1084/jem.20250733
Published: 22 October 2025
View article titled, Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells
Open the PDF for Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells in another window
Journal Articles

Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance

Masaya Arai, Ryoji Kawakami, Yamami Nakamura, Yoko Naito, Daisuke Motooka, Atsushi Sugimoto, Tomiko Kimoto, Naganari Ohkura, Norihisa Mikami, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (3): e20251635.
https://doi.org/10.1084/jem.20251635
Published: 21 October 2025
View article titled, Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance
Open the PDF for Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance in another window
Includes: Supplementary data
Journal Articles

Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state

In Special Collection:
Cytokines Collection 2025
Blanda Di Luccia, Liliana M. Massis, Daniel S.C. Butler, Ramya Narasimhan, Sarah J. Ruddle, Trung H.M. Pham, José G. Vilches-Moure, Denise M. Monack
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20242431.
https://doi.org/10.1084/jem.20242431
Published: 09 September 2025
View article titled, Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state
Open the PDF for Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state in another window
Includes: Supplementary data
Journal Articles

IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints

Adam J. Fike, Kristen N. Bricker, Michael V. Gonzalez, Anju Maharjan, Tien Bui, Keomonyroth Nuon, Scott M. Emrich, Julia L. Weber, Sara A. Luckenbill, Nicholas M. Choi, Renan Sauteraud, Dajiang J. Liu, Nancy J. Olsen, Roberto Caricchio, Mohamed Trebak, Sathi Babu Chodisetti, Ziaur S.M. Rahman
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20231882.
https://doi.org/10.1084/jem.20231882
Published: 29 May 2025
View article titled, IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
Open the PDF for IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints in another window
Journal Articles

“What’s in a name?” Clarifying the identity of RORγt+ antigen-presenting cells

Feiya Ou, Kenneth M. Murphy
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250760.
https://doi.org/10.1084/jem.20250760
Published: 15 May 2025
View article titled, “What’s in a name?” Clarifying the identity of RORγt+ antigen-presenting cells
Open the PDF for “What’s in a name?” Clarifying the identity of RORγt+ antigen-presenting cells in another window
Journal Articles

Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα

Artur Stoljar, Maksym Zarodniuk, Rudolf Bichele, Elise Helene Armulik, Uku Haljasorg, Romain Humeau, Marine Besnard, Liis Haljasmägi, Liina Tserel, Merili Peltser, Ahto Salumets, Eliisa Kekäläinen, Kai Kisand, Carole Guillonneau, Martti Laan, Pärt Peterson
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241403.
https://doi.org/10.1084/jem.20241403
Published: 30 April 2025
View article titled, Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα
Open the PDF for Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα in another window
Includes: Supplementary data
Journal Articles

RORγt eTACs mediate oral tolerance and Treg induction

Im-Hong Sun, Anita E. Qualls, Han S. Yin, Jiaxi Wang, Matthew P. Arvedson, Joe Germino, Nolan K. Horner, Sheng Zhong, Juan Du, Martin Valdearcos, Vasilis Ntranos, Richard M. Locksley, Roberto R. Ricardo-Gonzalez, James M. Gardner
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250573.
https://doi.org/10.1084/jem.20250573
Published: 29 April 2025
View article titled, RORγt eTACs mediate oral tolerance and Treg induction
Open the PDF for RORγt eTACs mediate oral tolerance and Treg induction in another window
Includes: Supplementary data
Journal Articles

Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus

Minoru Matsumoto, Masaki Yoshida, Takeshi Oya, Koichi Tsuneyama, Mitsuru Matsumoto, Hideyuki Yoshida
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20240817.
https://doi.org/10.1084/jem.20240817
Published: 17 April 2025
View article titled, Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus
Open the PDF for Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus in another window
Includes: Supplementary data
Journal Articles

Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection

Diana Muñoz Sandoval, Florian A. Bach, Alasdair Ivens, Adam C. Harding, Natasha L. Smith, Michalina Mazurczyk, Yrene Themistocleous, Nick J. Edwards, Sarah E. Silk, Jordan R. Barrett, Graeme J.M. Cowan, Giorgio Napolitani, Nicholas J. Savill, Simon J. Draper, Angela M. Minassian, Wiebke Nahrendorf, Philip J. Spence
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241667.
https://doi.org/10.1084/jem.20241667
Published: 11 April 2025
View article titled, Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection
Open the PDF for Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection in another window
Includes: Supplementary data
Journal Articles

CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy

In Special Collection:
Macrophages and Dendritic Cells in Health and Disease
Sirimuvva Tadepalli, Derek R. Clements, Hayley M. Raquer-McKay, Anja Lüdtke, Sanjana Saravanan, David Seong, Lorraine Vitek, Christopher M. Richards, Jan E. Carette, Matthias Mack, Andres Gottfried-Blackmore, Edward E. Graves, Juliana Idoyaga
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20231717.
https://doi.org/10.1084/jem.20231717
Published: 27 March 2025
View article titled, CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy
Open the PDF for CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy in another window
Includes: Supplementary data
Journal Articles

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer

In Special Collection:
JEM Immunology Collection 2025
Simon J. Cleary, Longhui Qiu, Yurim Seo, Peter Baluk, Dan Liu, Nina K. Serwas, Catherine A. Taylor, Dongliang Zhang, Jason G. Cyster, Donald M. McDonald, Matthew F. Krummel, Mark R. Looney
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241359.
https://doi.org/10.1084/jem.20241359
Published: 19 February 2025
View article titled, Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer
Open the PDF for Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer in another window
Includes: Supplementary data
Journal Articles

Finding NEMO in the thymus

Juan Moises Ocampo-Godinez, Alexandra Y. Kreins
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20241590.
https://doi.org/10.1084/jem.20241590
Published: 21 October 2024
View article titled, Finding NEMO in the thymus
Open the PDF for Finding NEMO in the thymus in another window
Journal Articles

The partitioning of TCR repertoires by thymic selection

In Special Collection:
Autoimmunity 2024
Wan-Lin Lo, Eric S. Huseby
Journal: Journal of Experimental Medicine
Series: Thymus and T Cell Development Focus
J Exp Med (2024) 221 (10): e20230897.
https://doi.org/10.1084/jem.20230897
Published: 21 August 2024
View article titled, The partitioning of TCR repertoires by thymic selection
Open the PDF for The partitioning of TCR repertoires by thymic selection in another window
Journal Articles

B cell tolerance and autoimmunity: Lessons from repertoires

In Special Collection:
JEM Immunology Collection 2025 , Autoimmunity 2024 , Immunity Review Series
Jacques Deguine, Ramnik J. Xavier
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20231314.
https://doi.org/10.1084/jem.20231314
Published: 02 August 2024
View article titled, B cell tolerance and autoimmunity: Lessons from repertoires
Open the PDF for B cell tolerance and autoimmunity: Lessons from repertoires in another window
Journal Articles

Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development

In Special Collection:
Autoimmunity 2024
Isabel Baldwin, Ellen A. Robey
Journal: Journal of Experimental Medicine
Series: Thymus and T Cell Development Focus
J Exp Med (2024) 221 (10): e20230896.
https://doi.org/10.1084/jem.20230896
Published: 09 July 2024
View article titled, Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development
Open the PDF for Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development in another window
Journal Articles

Generation and repair of thymic epithelial cells

In Special Collection:
Autoimmunity 2024 , Immunology Update Winter 2025
Graham Anderson, Emilie J. Cosway, Kieran D. James, Izumi Ohigashi, Yousuke Takahama
Journal: Journal of Experimental Medicine
Series: Thymus and T Cell Development Focus
J Exp Med (2024) 221 (10): e20230894.
https://doi.org/10.1084/jem.20230894
Published: 09 July 2024
View article titled, Generation and repair of thymic epithelial cells
Open the PDF for Generation and repair of thymic epithelial cells in another window
Journal Articles

Dynamic Foxp3–chromatin interaction controls tunable Treg cell function

In Special Collection:
Autoimmunity 2024
Minghong He, Xinying Zong, Beisi Xu, Wenjie Qi, Wenjun Huang, Mohamed Nadhir Djekidel, Yang Zhang, Vishwajeeth R. Pagala, Jun Li, Xiaolei Hao, Clifford Guy, Lu Bai, Richard Cross, Chunliang Li, Junmin Peng, Yongqiang Feng
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20232068.
https://doi.org/10.1084/jem.20232068
Published: 27 June 2024
View article titled, Dynamic Foxp3–chromatin interaction controls tunable Treg cell function
Open the PDF for Dynamic Foxp3–chromatin interaction controls tunable Treg cell function in another window
Includes: Supplementary data
Journal Articles

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity

In Special Collection:
Autoimmunity 2024 , JEM Immunology Collection 2024
Yaoyuan Zhang, Rhiannon Morris, Grant J. Brown, Ayla May D. Lorenzo, Xiangpeng Meng, Nadia J. Kershaw, Pamudika Kiridena, Gaétan Burgio, Simon Gross, Jean Y. Cappello, Qian Shen, Hao Wang, Cynthia Turnbull, Tom Lea-Henry, Maurice Stanley, Zhijia Yu, Fiona D. Ballard, Aaron Chuah, James C. Lee, Ann-Maree Hatch, Anselm Enders, Seth L. Masters, Alexander P. Headley, Peter Trnka, Dominic Mallon, Jeffery T. Fletcher, Giles D. Walters, Mario Šestan, Marija Jelušić, Matthew C. Cook, Vicki Athanasopoulos, David A. Fulcher, Jeffrey J. Babon, Carola G. Vinuesa, Julia I. Ellyard
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20221080.
https://doi.org/10.1084/jem.20221080
Published: 28 February 2024
View article titled, Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity
Open the PDF for Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity in another window
Includes: Supplementary data
Journal Articles

Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance

In Special Collection:
Autoimmunity 2024 , Lymphatic Vessels in Health and Disease 2024 , Neuroscience Collection 2024
Hyunjung Min, Shane M. O’Neil, Li Xu, E. Ashley Moseman, Joanne Kurtzberg, Anthony J. Filiano
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (2): e20230326.
https://doi.org/10.1084/jem.20230326
Published: 09 January 2024
View article titled, Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance
Open the PDF for Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance in another window
Includes: Supplementary data
Journal Articles

Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes

In Special Collection:
Barrier Immunity , Immunology Update Winter 2024
Jianing Fu, Zicheng Wang, Mercedes Martinez, Aleksandar Obradovic, Wenyu Jiao, Kristjana Frangaj, Rebecca Jones, Xinzheng V. Guo, Ya Zhang, Wan-I Kuo, Huaibin M. Ko, Alina Iuga, Constanza Bay Muntnich, Adriana Prada Rey, Kortney Rogers, Julien Zuber, Wenji Ma, Michelle Miron, Donna L. Farber, Joshua Weiner, Tomoaki Kato, Yufeng Shen, Megan Sykes
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (1): e20230930.
https://doi.org/10.1084/jem.20230930
Published: 13 December 2023
View article titled, Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes
Open the PDF for Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes in another window
Includes: Supplementary data