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Journal Articles

pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection

Elena Hernández-García, Miguel Galán, Sofía C. Khouili, Elena Moya-Ruiz, Ana Redondo-Urzainqui, Francisco J. Cueto, Saraí Martínez-Cano, Manuel Rodrigo-Tapias, Elena Tomasello, Santos Mañes, Marc Dalod, David Sancho, Salvador Iborra
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20250099.
https://doi.org/10.1084/jem.20250099
Published: 25 November 2025
View article titled, pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection
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Journal Articles

SLC7A8 is essential for metabolic fitness and function of Th2 cells

Santosh K. Panda, Do-Hyun Kim, Pritesh Desai, Shitong Wu, Patrick Fernandes Rodrigues, Raki Sudan, Yizhou Liu, Haerin Jung, Intelly Lee, Susan Gilfillan, Marina Cella, Steven J. Van Dyken, Marco Colonna
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20250439.
https://doi.org/10.1084/jem.20250439
Published: 21 November 2025
View article titled, SLC7A8 is essential for metabolic fitness and function of Th2 cells
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Journal Articles

Xbp1 controls the reparative function of intestinal ILC2s during colitis

Yanyan Cui, Zixiao Zhao, Jing Shen, Yatai Chen, Qiuheng Tian, Yang Liu, Yunjiao Zhai, Bowen Xu, Jiajie Hou, Chunyang Li, Yanbo Yu, Xiaohuan Guo, Ju Qiu, Detian Yuan, Shiyang Li
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20250440.
https://doi.org/10.1084/jem.20250440
Published: 30 October 2025
View article titled, Xbp1 controls the reparative function of intestinal ILC2s during colitis
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Includes: Supplementary data
Journal Articles

Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms

Cameron Bissett, Lyn Yong, Alexandra J. Spencer, Fionn Nok Lam Ma, Ethan A. Courchesne, Reshma Koolaparambil Mukesh, Marta Ulaszewska, Alexander Sampson, Marie Lucienne, Reshma Kailath, Susan Morris, Claire Powers, Sandra Belij-Rammerstorfer, Vincent J. Munster, Neeltje van Doremalen, Nicholas M. Provine, Teresa Lambe
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20241529.
https://doi.org/10.1084/jem.20241529
Published: 30 October 2025
View article titled, Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms
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Includes: Supplementary data
Journal Articles

Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance

Masaya Arai, Ryoji Kawakami, Yamami Nakamura, Yoko Naito, Daisuke Motooka, Atsushi Sugimoto, Tomiko Kimoto, Naganari Ohkura, Norihisa Mikami, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (3): e20251635.
https://doi.org/10.1084/jem.20251635
Published: 21 October 2025
View article titled, Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance
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Includes: Supplementary data
Journal Articles

Lung tissue–resident memory T cells optimize protection by IL-10 regulation of innate immunity

Alexander Y. Yang, Julia Davis-Porada, Daniel H. Paik, Alex B. George, Brea H. Brown, Paige L. Ruschke, Peter A. Sims, Ziv Frankenstein, Anjali Saqi, Donna L. Farber
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20242307.
https://doi.org/10.1084/jem.20242307
Published: 13 October 2025
View article titled, Lung tissue–resident memory T cells optimize protection by IL-10 regulation of innate immunity
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Includes: Supplementary data
Journal Articles

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation

Jinjin Xu, Lingjia Kong, Elizabeth A. Creasey, Sneha Rath, Lei Deng, Julian Avila-Pacheco, Chenhao Li, Blayne A. Oliver, Tyler T. Dao, Angela R. Shih, Mark J. Daly, Alex K. Shalek, Clary B. Clish, Daniel B. Graham, Jacques Deguine, Ramnik J. Xavier
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20250185.
https://doi.org/10.1084/jem.20250185
Published: 11 September 2025
View article titled, Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation
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Includes: Supplementary data
Journal Articles

TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming

In Special Collection:
Cytokines Collection 2025 , Pattern Recognition Receptors and Beyond
Wenjie Zhu, Xiaoyan Xu, Vijayaraj Nagarajan, Jing Guo, Akriti Gupta, Zixuan Peng, Amy Zhang, Jie Liu, Mary J. Mattapallil, Yingyos Jittayasothorn, Reiko Horai, Yasmine Belkaid, Michael G. Constantinides, Anthony J. St Leger, Rachel R. Caspi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20251046.
https://doi.org/10.1084/jem.20251046
Published: 11 September 2025
View article titled, TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming
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Includes: Supplementary data
Journal Articles

Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state

In Special Collection:
Cytokines Collection 2025
Blanda Di Luccia, Liliana M. Massis, Daniel S.C. Butler, Ramya Narasimhan, Sarah J. Ruddle, Trung H.M. Pham, José G. Vilches-Moure, Denise M. Monack
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20242431.
https://doi.org/10.1084/jem.20242431
Published: 09 September 2025
View article titled, Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state
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Includes: Supplementary data
Journal Articles

Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn’s disease

In Special Collection:
Journal-Based CME Activities with Journal of Experimental Medicine (JEM)
Mitsuru Arase, Mari Murakami, Takako Kihara, Ryuichi Kuwahara, Hironobu Toyota, Naoki Sumitani, Naohiko Kinoshita, Kelvin Y. Chen, Takehito Yokoi, Daisuke Motooka, Daisuke Okuzaki, Yuhe Zhao, Hazuki Miyazaki, Takayuki Ogino, Seiichi Hirota, Hiroki Ikeuchi, Kiyoshi Takeda
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20242106.
https://doi.org/10.1084/jem.20242106
Published: 04 September 2025
View article titled, Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn’s disease
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Includes: Supplementary data
Journal Articles

Ciliated cell–derived IL-17D restrains allergic asthma through controlling monocyte recruitment

In Special Collection:
Cytokines Collection 2025 , Macrophages and Dendritic Cells in Health and Disease
Lei Yuan, Jinling Huang, Jianhui Chen, Tian Xie, Genyu Wang, Bowen Xie, Lei Qin, Yongzhen Chen, Xuan Zhong, Zixuan Zhao, Zhilin Peng, Xiaoshuang Wang, Miao Xu, Jing Ge, Xiaohu Wang, Chen Dong
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20242328.
https://doi.org/10.1084/jem.20242328
Published: 05 August 2025
View article titled, Ciliated cell–derived IL-17D restrains allergic asthma through controlling monocyte recruitment
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Includes: Supplementary data
Journal Articles

Epigenetic priming as a driver of memory recall and dysfunction in T cells

Mieke Metzemaekers, Niels J. Rinzema, Ralph Stadhouders
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20241433.
https://doi.org/10.1084/jem.20241433
Published: 31 July 2025
View article titled, Epigenetic priming as a driver of memory recall and dysfunction in T cells
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Journal Articles

Early and opposing neutrophil and CD4 T cell responses shape pulmonary tuberculosis pathology

Benjamin H. Gern, Josepha M. Klas, Kimberly A. Foster, Molly E. Kanagy, Sara B. Cohen, Courtney R. Plumlee, Fergal J. Duffy, Maxwell L. Neal, Mehnaz Halima, Andrew T. Gustin, Sylvia M. Stull, Jasmine J. Wilson, Alan H. Diercks, Alan Aderem, Michael Gale, Jr., John D. Aitchison, Michael Y. Gerner, Kevin B. Urdahl
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20250161.
https://doi.org/10.1084/jem.20250161
Published: 30 July 2025
View article titled, Early and opposing neutrophil and CD4 T cell responses shape pulmonary tuberculosis pathology
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Includes: Supplementary data
Journal Articles

S1PR1, an endothelial-immune influencer

Samantha Mahfoud, Timothy P. Padera
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20251056.
https://doi.org/10.1084/jem.20251056
Published: 15 July 2025
View article titled, S1PR1, an endothelial-immune influencer
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Journal Articles

Intestinal lymphatic vasculature is functionally adapted to different drainage regions and is altered by helminth infection

Jorden I. Lane, Elida Nieves-Ortiz, Ornella Ndatabaye, Aliia R. Fatkhullina, Sebastian Lopez, Terence S. Dermody, Daria Esterházy
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20241181.
https://doi.org/10.1084/jem.20241181
Published: 12 June 2025
View article titled, Intestinal lymphatic vasculature is functionally adapted to different drainage regions and is altered by helminth infection
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Includes: Supplementary data
Journal Articles

Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis

Riem Gawish, Rajagopal Varada, Florian Deckert, Anastasiya Hladik, Linda Steinbichl, Laura Cimatti, Katarina Milanovic, Mamta Jain, Natalya Torgasheva, Andrea Tanzer, Kim De Paepe, Tom Van de Wiele, Bela Hausmann, Michaela Lang, Martin Pechhacker, Nahla Ibrahim, Ingrid De Vries, Christine Brostjan, Michael Sixt, Christoph Gasche, Louis Boon, David Berry, Michael F. Jantsch, Fatima C. Pereira, Cornelia Vesely
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20240109.
https://doi.org/10.1084/jem.20240109
Published: 05 June 2025
View article titled, Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis
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Includes: Supplementary data
Journal Articles

Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis

Ahmed Kabil, Natalia Nayyar, Chengxi Xu, Julyanne Brassard, Lesley A. Hill, Samuel B. Shin, Sameeksha Chopra, Bernard Lo, Yicong Li, Mya Bal, Marine Theret, Fabio M.V. Rossi, T. Michael Underhill, Michael R. Hughes, Kelly M. McNagny
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241671.
https://doi.org/10.1084/jem.20241671
Published: 28 May 2025
View article titled, Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis
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Includes: Supplementary data
Journal Articles

Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation

Chae Won Kim, Hyun-Jin Kim, In Kang, Keun Bon Ku, Yumin Kim, Jang Hyun Park, Juhee Lim, Byeong Hoon Kang, Won Hyung Park, Jeongwoo La, Sungwoo Chang, Inju Hwang, Minji Kim, Stephen Ahn, Heung Kyu Lee
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241135.
https://doi.org/10.1084/jem.20241135
Published: 22 May 2025
View article titled, Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation
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Includes: Supplementary data
Journal Articles

Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon

Åsa Johansson, Mahadevan Venkita Subramani, Bahtiyar Yilmaz, Elisabeth E.L. Nyström, Elena Layunta, Liisa Arike, Felix Sommer, Philip Rosenstiel, Lars Vereecke, Louise Mannerås-Holm, Andy Wullaert, Thaher Pelaseyed, Malin E.V. Johansson, George M.H. Birchenough
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241591.
https://doi.org/10.1084/jem.20241591
Published: 05 May 2025
View article titled, Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon
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Journal Articles

Microbiota-centered interventions to boost immune checkpoint blockade therapies

In Special Collection:
JEM Clinical Immunology Collection 2025
Andrew A. Almonte, Simon Thomas, Laurence Zitvogel
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (7): e20250378.
https://doi.org/10.1084/jem.20250378
Published: 22 April 2025
View article titled, Microbiota-centered interventions to boost immune checkpoint blockade therapies
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