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Journal Articles

Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis

Jie Li, Mei-Ting Yang, Mami Matsuda-Lennikov, Felix Kalle-Youngoue, Aya Ushio, Kenta Kondo, Meleca Gluckman, Kana Bando, Takaya Abe, Kensuke Takada, Michael C. Kelly, Felipe Castro Martinez, Zuojia Chen, Chuan Wu, Yousuke Takahama

J Exp Med (2026) 223 (6): e20252527.

https://doi.org/10.1084/jem.20252527

Published: 12 May 2026

View article titled, Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis

Includes: Supplementary data

Journal Articles

BACH2 controls ILC3 function via PPARγ-dependent mitochondrial metabolism

In Special Collection:

Inflammation Resolution 2026

Jianye Wang, Ying Wang, Gaoyu Liu, Jinhao Yang, Houjia Hu, Hailong Cao, Shuo Wang, Xuanlin Liu, Jingyi Wu, Meng Yao, Xiaolei Pan, Pan Zhou, Ying Yu, Zuoqing Song, Qiang Liu, Jie Zhou

J Exp Med (2026) 223 (6): e20251918.

https://doi.org/10.1084/jem.20251918

Published: 28 April 2026

View article titled, BACH2 controls ILC3 function via PPARγ-dependent mitochondrial metabolism

Includes: Supplementary data

Journal Articles

Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection

In Special Collection:

Inflammation Resolution 2026

Jiseon Kim, Joseph R. Dominguez, Seung Hyeon Kim, Zachary White, Jaewon Cho, Jungmin Hwang, Yeonwoo Choi, Soroush Tahmasebi, Teruyuki Sano, Jinki Yeom, Ki-Wook Kim

J Exp Med (2026) 223 (6): e20251492.

https://doi.org/10.1084/jem.20251492

Published: 28 April 2026

View article titled, Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection

Journal Articles

Staying IgD positive in a challenging environment

Kim L. Good-Jacobson

J Exp Med (2026) 223 (5): e20260394.

https://doi.org/10.1084/jem.20260394

Published: 24 April 2026

View article titled, Staying IgD positive in a challenging environment

Journal Articles

IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens

J Exp Med (2026) 223 (5): e20251752.

https://doi.org/10.1084/jem.20251752

Published: 24 April 2026

View article titled, IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens

Includes: Supplementary data

Journal Articles

B7 costimulation antagonizes RORγt⁺ regulatory T cells and immune tolerance in the intestine

In Special Collection:

Inflammation Resolution 2026

Mengze Lyu, Gregory F. Sonnenberg

J Exp Med (2026) 223 (6): e20251094.

https://doi.org/10.1084/jem.20251094

Published: 24 April 2026

View article titled, B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine

Journal Articles

CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β

J Exp Med (2026) 223 (5): e20240801.

https://doi.org/10.1084/jem.20240801

Published: 21 April 2026

View article titled, CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β

Includes: Supplementary data

Journal Articles

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas

Yufan Zheng, Makheni Jean Pierre, Eduard Ansaldo, Hannah E. Dobson, Olena Kamenyeva, Chinaemerem U. Onyishi, Sarah Douglas, Christopher Febres Aldana, Pinar Engin Zerk, Irini Sereti, Jovany J. Betancourt, Kirsten Nielsen, Erin McCaffery, Eric V. Dang

J Exp Med (2026) 223 (5): e20260208.

https://doi.org/10.1084/jem.20260208

Published: 20 April 2026

View article titled, Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas

Journal Articles

Nasal CD4⁺ tissue-resident memory T cells provide cross-protective immunity to influenza

Nimitha R. Mathew, Romain Gailleton, Lydia Scharf, Karin Schön, Josue Enriquez, Hannes Axelsson, Anneli Strömberg, Nils Lycke, Mats Bemark, Ka-Wei Tang, Davide Angeletti

J Exp Med (2026) 223 (5): e20251793.

https://doi.org/10.1084/jem.20251793

Published: 06 April 2026

View article titled, Nasal CD4+ tissue-resident memory T cells provide cross-protective immunity to influenza

Includes: Supplementary data

Journal Articles

Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity

Patrycja M. Forster, Alexandra Preußer, Hiroshi Yano, Divija Deshpande, Wen Zhang, Anita Kowalczyk, Laura Velleman, Magdalena O. Dubik, Jazib Uddin, Elizabeth R. Emanuel, Pierre S. Leclère, Richard Mertens, Xuemei Gao, Michael Kofoed-Branzk, Anja E. Hauser, Hans-Willi Mittrücker, Andreas Diefenbach, David Artis, Christoph S.N. Klose

J Exp Med (2026) 223 (5): e20250781.

https://doi.org/10.1084/jem.20250781

Published: 31 March 2026

View article titled, Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity

Includes: Supplementary data

Journal Articles

Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes

J Exp Med (2026) 223 (4): e20252667.

https://doi.org/10.1084/jem.20252667

Published: 03 March 2026

View article titled, Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes

Includes: Supplementary data

Journal Articles

Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment

In Special Collection:

Inflammation Resolution 2026

J Exp Med (2026) 223 (4): e20251761.

https://doi.org/10.1084/jem.20251761

Published: 03 March 2026

View article titled, Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment

Includes: Supplementary data

Journal Articles

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells

J Exp Med (2026) 223 (3): e20241707.

https://doi.org/10.1084/jem.20241707

Published: 28 January 2026

View article titled, DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells

Includes: Supplementary data

Journal Articles

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood

In Special Collection:

Immunology Update Winter 2026

Gabrielle R. LeBlanc, Adam L. Sobel, Jonathan Melamed, Dominic Haas, Eduard Ansaldo, Aiko M. Cirone, Elizabeth Murguia, Michael G. Constantinides

J Exp Med (2025) 223 (3): e20241287.

https://doi.org/10.1084/jem.20241287

Published: 16 December 2025

View article titled, Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood

Journal Articles

Fibroblast diversity within human gut-associated lymphoid tissues

In Special Collection:

Immunology Update Winter 2026 , JEM Immunology Collection 2026

Urs M. Mörbe, Fredrik V. Junghus, Grigorii Nos, Peter B. Jørgensen, Melissa J. Ensmenger, Venla A. Väänänen, Mads D. Wewer, Gorm R. Madsen, Lene B. Riis, Henrik L. Jakobsen, Lars R. Olsen, Søren Brunak, Ole H. Nielsen, William W. Agace

J Exp Med (2025) 223 (3): e20250471.

https://doi.org/10.1084/jem.20250471

Published: 11 December 2025

View article titled, Fibroblast diversity within human gut-associated lymphoid tissues

Includes: Supplementary data

Journal Articles

pDCs amplify tissue-resident memory CD8⁺ T cell responses during viral reinfection

In Special Collection:

Hematopoietic Stem Cells and Myeloid Lineages in Health and Disease

Elena Hernández-García, Miguel Galán, Sofía C. Khouili, Elena Moya-Ruiz, Ana Redondo-Urzainqui, Francisco J. Cueto, Saraí Martínez-Cano, Manuel Rodrigo-Tapias, Elena Tomasello, Santos Mañes, Marc Dalod, David Sancho, Salvador Iborra

J Exp Med (2025) 223 (2): e20250099.

https://doi.org/10.1084/jem.20250099

Published: 25 November 2025

View article titled, pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection

Journal Articles

SLC7A8 is essential for metabolic fitness and function of Th2 cells

In Special Collection:

Immunology Update Winter 2026

Santosh K. Panda, Do-Hyun Kim, Pritesh Desai, Shitong Wu, Patrick Fernandes Rodrigues, Raki Sudan, Yizhou Liu, Haerin Jung, Intelly Lee, Susan Gilfillan, Marina Cella, Steven J. Van Dyken, Marco Colonna

J Exp Med (2025) 223 (2): e20250439.

https://doi.org/10.1084/jem.20250439

Published: 21 November 2025

View article titled, SLC7A8 is essential for metabolic fitness and function of Th2 cells

Journal Articles

Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms

Cameron Bissett, Lyn Yong, Alexandra J. Spencer, Fionn Nok Lam Ma, Ethan A. Courchesne, Reshma Koolaparambil Mukesh, Marta Ulaszewska, Alexander Sampson, Marie Lucienne, Reshma Kailath, Susan Morris, Claire Powers, Sandra Belij-Rammerstorfer, Vincent J. Munster, Neeltje van Doremalen, Nicholas M. Provine, Teresa Lambe

J Exp Med (2025) 223 (1): e20241529.

https://doi.org/10.1084/jem.20241529

Published: 30 October 2025

View article titled, Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms

Includes: Supplementary data

Journal Articles

Xbp1 controls the reparative function of intestinal ILC2s during colitis

In Special Collection:

Inflammation Resolution 2026

Yanyan Cui, Zixiao Zhao, Jing Shen, Yatai Chen, Qiuheng Tian, Yang Liu, Yunjiao Zhai, Bowen Xu, Jiajie Hou, Chunyang Li, Yanbo Yu, Xiaohuan Guo, Ju Qiu, Detian Yuan, Shiyang Li

J Exp Med (2025) 223 (1): e20250440.

https://doi.org/10.1084/jem.20250440

Published: 30 October 2025

View article titled, Xbp1 controls the reparative function of intestinal ILC2s during colitis

Includes: Supplementary data

Journal Articles

Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance

In Special Collection:

2025 Nobel Prize Collection , Immunology Update Winter 2026

Masaya Arai, Ryoji Kawakami, Yamami Nakamura, Yoko Naito, Daisuke Motooka, Atsushi Sugimoto, Tomiko Kimoto, Naganari Ohkura, Norihisa Mikami, Shimon Sakaguchi

J Exp Med (2025) 223 (3): e20251635.

https://doi.org/10.1084/jem.20251635

Published: 21 October 2025

View article titled, Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance

Includes: Supplementary data

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Article Type

Date

Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis

BACH2 controls ILC3 function via PPARγ-dependent mitochondrial metabolism

Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection

Staying IgD positive in a challenging environment

IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens

B7 costimulation antagonizes RORγt⁺ regulatory T cells and immune tolerance in the intestine

CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas

Nasal CD4⁺ tissue-resident memory T cells provide cross-protective immunity to influenza

Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity

Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes

Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood

Fibroblast diversity within human gut-associated lymphoid tissues

pDCs amplify tissue-resident memory CD8⁺ T cell responses during viral reinfection

SLC7A8 is essential for metabolic fitness and function of Th2 cells

Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms

Xbp1 controls the reparative function of intestinal ILC2s during colitis

Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance

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