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Journal Articles

Nasal CD4+ tissue-resident memory T cells provide cross-protective immunity to influenza

Nimitha R. Mathew, Romain Gailleton, Lydia Scharf, Karin Schön, Josue Enriquez, Hannes Axelsson, Anneli Strömberg, Nils Lycke, Mats Bemark, Ka-Wei Tang, Davide Angeletti
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (5): e20251793.
https://doi.org/10.1084/jem.20251793
Published: 06 April 2026
View article titled, Nasal CD4+ tissue-resident memory T cells provide cross-protective immunity to influenza
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Includes: Supplementary data
Journal Articles

Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity

Patrycja M. Forster, Alexandra Preußer, Hiroshi Yano, Divija Deshpande, Wen Zhang, Anita Kowalczyk, Laura Velleman, Magdalena O. Dubik, Jazib Uddin, Elizabeth R. Emanuel, Pierre S. Leclère, Richard Mertens, Xuemei Gao, Michael Kofoed-Branzk, Anja E. Hauser, Hans-Willi Mittrücker, Andreas Diefenbach, David Artis, Christoph S.N. Klose
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (5): e20250781.
https://doi.org/10.1084/jem.20250781
Published: 31 March 2026
View article titled, Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity
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Includes: Supplementary data
Journal Articles

Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment

Sravya Kurapati, Changsik Shin, Krisztina Szabo, Yu Liu, Azree Z. Ashraf, Balazs Koscso, Chinmayee Dash, Katherine L. Kruckow, Leonardo E. Navarro, Amanda M. Clark, Monalee Saha, Sushma Nagaraj, Wenhui Wang, Jun Zhu, Kevin Brown, Travis Thomson, Natalia Shulzhenko, Andrey Morgun, Christina E. Baer, Shanthi Srinivasan, Subhash Kulkarni, Pankaj J. Pasricha, Lauren A. Peters, Milena Bogunovic
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (4): e20251761.
https://doi.org/10.1084/jem.20251761
Published: 03 March 2026
View article titled, Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment
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Includes: Supplementary data
Journal Articles

Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes

Laura Bub, Elza Evren, Stijn Verwaerde, Cecilia Ruscitti, Domien Vanneste, Pia Ghosh, Yu Gao, Natalie Sleiers, Rong Deng, Marta López Montes, Kelsey Howley, Raphaël La Rocca, Annika Niehrs, Vassilis Glaros, Maria Reina-Campos, Barbro Dahlen, Anna Smed-Sörensen, Harald Lund, Taras Kreslavsky, Niklas K. Björkström, Andrea Reboldi, Apostolos Bossios, Thomas Marichal, Bart N. Lambrecht, Tim Willinger
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (4): e20252667.
https://doi.org/10.1084/jem.20252667
Published: 03 March 2026
View article titled, Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes
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Includes: Supplementary data
Journal Articles

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells

Emily R. Siniscalco, Courtney Fisher, Meng-Ping Lu, Jessica D.S. Grassmann, Corinne D. Mack, Roukaya Yaakoubi, Danielle Jacobsen, Qian Chen, Donguk Lee, Priya Rajamanimuthu, Tregony Simoneau, Kahn Preece, Paul Gray, Satoshi Okada, Bertrand Boisson, Basak Kayaoglu, Jeffrey Danielson, Alexandra F. Freeman, Jean-Laurent Casanova, Talal A. Chatila, Helen C. Su, Cindy S. Ma, Adam Williams, Stephanie C. Eisenbarth, Uthaman Gowthaman
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (3): e20241707.
https://doi.org/10.1084/jem.20241707
Published: 28 January 2026
View article titled, DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells
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Includes: Supplementary data
Journal Articles

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood

In Special Collection:
Immunology Update Winter 2026
Gabrielle R. LeBlanc, Adam L. Sobel, Jonathan Melamed, Dominic Haas, Eduard Ansaldo, Aiko M. Cirone, Elizabeth Murguia, Michael G. Constantinides
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (3): e20241287.
https://doi.org/10.1084/jem.20241287
Published: 16 December 2025
View article titled, Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood
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Journal Articles

Fibroblast diversity within human gut-associated lymphoid tissues

In Special Collection:
Immunology Update Winter 2026 , JEM Immunology Collection 2026
Urs M. Mörbe, Fredrik V. Junghus, Grigorii Nos, Peter B. Jørgensen, Melissa J. Ensmenger, Venla A. Väänänen, Mads D. Wewer, Gorm R. Madsen, Lene B. Riis, Henrik L. Jakobsen, Lars R. Olsen, Søren Brunak, Ole H. Nielsen, William W. Agace
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (3): e20250471.
https://doi.org/10.1084/jem.20250471
Published: 11 December 2025
View article titled, Fibroblast diversity within human gut-associated lymphoid tissues
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Includes: Supplementary data
Journal Articles

pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection

In Special Collection:
Hematopoietic Stem Cells and Myeloid Lineages in Health and Disease
Elena Hernández-García, Miguel Galán, Sofía C. Khouili, Elena Moya-Ruiz, Ana Redondo-Urzainqui, Francisco J. Cueto, Saraí Martínez-Cano, Manuel Rodrigo-Tapias, Elena Tomasello, Santos Mañes, Marc Dalod, David Sancho, Salvador Iborra
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20250099.
https://doi.org/10.1084/jem.20250099
Published: 25 November 2025
View article titled, pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection
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Journal Articles

SLC7A8 is essential for metabolic fitness and function of Th2 cells

In Special Collection:
Immunology Update Winter 2026
Santosh K. Panda, Do-Hyun Kim, Pritesh Desai, Shitong Wu, Patrick Fernandes Rodrigues, Raki Sudan, Yizhou Liu, Haerin Jung, Intelly Lee, Susan Gilfillan, Marina Cella, Steven J. Van Dyken, Marco Colonna
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20250439.
https://doi.org/10.1084/jem.20250439
Published: 21 November 2025
View article titled, SLC7A8 is essential for metabolic fitness and function of Th2 cells
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Journal Articles

Xbp1 controls the reparative function of intestinal ILC2s during colitis

Yanyan Cui, Zixiao Zhao, Jing Shen, Yatai Chen, Qiuheng Tian, Yang Liu, Yunjiao Zhai, Bowen Xu, Jiajie Hou, Chunyang Li, Yanbo Yu, Xiaohuan Guo, Ju Qiu, Detian Yuan, Shiyang Li
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20250440.
https://doi.org/10.1084/jem.20250440
Published: 30 October 2025
View article titled, Xbp1 controls the reparative function of intestinal ILC2s during colitis
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Includes: Supplementary data
Journal Articles

Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms

Cameron Bissett, Lyn Yong, Alexandra J. Spencer, Fionn Nok Lam Ma, Ethan A. Courchesne, Reshma Koolaparambil Mukesh, Marta Ulaszewska, Alexander Sampson, Marie Lucienne, Reshma Kailath, Susan Morris, Claire Powers, Sandra Belij-Rammerstorfer, Vincent J. Munster, Neeltje van Doremalen, Nicholas M. Provine, Teresa Lambe
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20241529.
https://doi.org/10.1084/jem.20241529
Published: 30 October 2025
View article titled, Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms
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Includes: Supplementary data
Journal Articles

Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance

In Special Collection:
2025 Nobel Prize Collection , Immunology Update Winter 2026
Masaya Arai, Ryoji Kawakami, Yamami Nakamura, Yoko Naito, Daisuke Motooka, Atsushi Sugimoto, Tomiko Kimoto, Naganari Ohkura, Norihisa Mikami, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (3): e20251635.
https://doi.org/10.1084/jem.20251635
Published: 21 October 2025
View article titled, Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance
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Includes: Supplementary data
Journal Articles

Lung tissue–resident memory T cells optimize protection by IL-10 regulation of innate immunity

In Special Collection:
Innate Immune Signaling in Infection and Disease
Alexander Y. Yang, Julia Davis-Porada, Daniel H. Paik, Alex B. George, Brea H. Brown, Paige L. Ruschke, Peter A. Sims, Ziv Frankenstein, Anjali Saqi, Donna L. Farber
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20242307.
https://doi.org/10.1084/jem.20242307
Published: 13 October 2025
View article titled, Lung tissue–resident memory T cells optimize protection by IL-10 regulation of innate immunity
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Includes: Supplementary data
Journal Articles

TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming

In Special Collection:
Pattern Recognition Receptors and Beyond , Cytokines Collection 2025
Wenjie Zhu, Xiaoyan Xu, Vijayaraj Nagarajan, Jing Guo, Akriti Gupta, Zixuan Peng, Amy Zhang, Jie Liu, Mary J. Mattapallil, Yingyos Jittayasothorn, Reiko Horai, Yasmine Belkaid, Michael G. Constantinides, Anthony J. St Leger, Rachel R. Caspi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20251046.
https://doi.org/10.1084/jem.20251046
Published: 11 September 2025
View article titled, TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming
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Includes: Supplementary data
Journal Articles

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation

Jinjin Xu, Lingjia Kong, Elizabeth A. Creasey, Sneha Rath, Lei Deng, Julian Avila-Pacheco, Chenhao Li, Blayne A. Oliver, Tyler T. Dao, Angela R. Shih, Mark J. Daly, Alex K. Shalek, Clary B. Clish, Daniel B. Graham, Jacques Deguine, Ramnik J. Xavier
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20250185.
https://doi.org/10.1084/jem.20250185
Published: 11 September 2025
View article titled, Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation
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Includes: Supplementary data
Journal Articles

Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state

In Special Collection:
Cytokines Collection 2025
Blanda Di Luccia, Liliana M. Massis, Daniel S.C. Butler, Ramya Narasimhan, Sarah J. Ruddle, Trung H.M. Pham, José G. Vilches-Moure, Denise M. Monack
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20242431.
https://doi.org/10.1084/jem.20242431
Published: 09 September 2025
View article titled, Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state
Open the PDF for Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state in another window
Includes: Supplementary data
Journal Articles

Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn’s disease

In Special Collection:
Journal-Based CME Activities with Journal of Experimental Medicine (JEM)
Mitsuru Arase, Mari Murakami, Takako Kihara, Ryuichi Kuwahara, Hironobu Toyota, Naoki Sumitani, Naohiko Kinoshita, Kelvin Y. Chen, Takehito Yokoi, Daisuke Motooka, Daisuke Okuzaki, Yuhe Zhao, Hazuki Miyazaki, Takayuki Ogino, Seiichi Hirota, Hiroki Ikeuchi, Kiyoshi Takeda
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20242106.
https://doi.org/10.1084/jem.20242106
Published: 04 September 2025
View article titled, Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn’s disease
Open the PDF for Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn’s disease in another window
Includes: Supplementary data
Journal Articles

Ciliated cell–derived IL-17D restrains allergic asthma through controlling monocyte recruitment

In Special Collection:
Macrophages and Dendritic Cells in Health and Disease , Cytokines Collection 2025
Lei Yuan, Jinling Huang, Jianhui Chen, Tian Xie, Genyu Wang, Bowen Xie, Lei Qin, Yongzhen Chen, Xuan Zhong, Zixuan Zhao, Zhilin Peng, Xiaoshuang Wang, Miao Xu, Jing Ge, Xiaohu Wang, Chen Dong
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20242328.
https://doi.org/10.1084/jem.20242328
Published: 05 August 2025
View article titled, Ciliated cell–derived IL-17D restrains allergic asthma through controlling monocyte recruitment
Open the PDF for Ciliated cell–derived IL-17D restrains allergic asthma through controlling monocyte recruitment in another window
Includes: Supplementary data
Journal Articles

Epigenetic priming as a driver of memory recall and dysfunction in T cells

Mieke Metzemaekers, Niels J. Rinzema, Ralph Stadhouders
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20241433.
https://doi.org/10.1084/jem.20241433
Published: 31 July 2025
View article titled, Epigenetic priming as a driver of memory recall and dysfunction in T cells
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Journal Articles

Early and opposing neutrophil and CD4 T cell responses shape pulmonary tuberculosis pathology

In Special Collection:
Updates on the Immune Responses to Tuberculosis and HIV
Benjamin H. Gern, Josepha M. Klas, Kimberly A. Foster, Molly E. Kanagy, Sara B. Cohen, Courtney R. Plumlee, Fergal J. Duffy, Maxwell L. Neal, Mehnaz Halima, Andrew T. Gustin, Sylvia M. Stull, Jasmine J. Wilson, Alan H. Diercks, Alan Aderem, Michael Gale, Jr., John D. Aitchison, Michael Y. Gerner, Kevin B. Urdahl
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20250161.
https://doi.org/10.1084/jem.20250161
Published: 30 July 2025
View article titled, Early and opposing neutrophil and CD4 T cell responses shape pulmonary tuberculosis pathology
Open the PDF for Early and opposing neutrophil and CD4 T cell responses shape pulmonary tuberculosis pathology in another window
Includes: Supplementary data

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