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Journal Articles

Flawed translation triggers oncogenic B–T cell communication

Seren Baygün, Marc Schmidt-Supprian
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20260912.
https://doi.org/10.1084/jem.20260912
Published: 24 June 2026
View article titled, Flawed translation triggers oncogenic B–T cell communication
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Journal Articles

eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy

Lianghua Lin, Pengda Chen, Jiazhen Wang, Chao Huang, Xinyong Lin, Chenfeng Liu, Kunyu Liao, Jianfeng Wu, Amy Chadburn, Yunjie Zhang, Huilin Song, Chenxi Wang, Zhichen Wan, Jiayi Zhao, Guangyi Cao, Xinming Wang, Liang Yang, Nan Yao, Yazhen Hong, Zhengtao Xiao, Dieter A. Wolf, Wen-Hsien Liu, Changchun Xiao
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20251968.
https://doi.org/10.1084/jem.20251968
Published: 03 June 2026
View article titled, eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy
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Includes: Supplementary data
Journal Articles

Cathepsin S regulates germinal center reactions and anti-tumor humoral responses

Marine Bruand, Divyanshu Srivastava, Aaron Petruzzella, Maxime Petit, Samantha Mahfoud, Natalya Katanayeva, Asli Kasapoglu, Camille Landragin, Daniele Tavernari, Eleni Balli, Giovanni Ciriello, Tatiana V. Petrova, Elisa Oricchio
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20252463.
https://doi.org/10.1084/jem.20252463
Published: 01 June 2026
View article titled, Cathepsin S regulates germinal center reactions and anti-tumor humoral responses
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Includes: Supplementary data
Journal Articles

Reprogramming endogenous NK circuits by highly efficient nonviral genome editing

Rih-Sheng Huang, Shee Kwan Phung, Darin Sumstad, Anna J. Weis, Quinlan M. Kile, Laura Bendzick, Melissa J. Khaw, Young Y. Vue, David H. McKenna, Philippa R. Kennedy, Jeffrey S. Miller, Martin Felices
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20260192.
https://doi.org/10.1084/jem.20260192
Published: 13 May 2026
View article titled, Reprogramming endogenous NK circuits by highly efficient nonviral genome editing
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Includes: Supplementary data
Journal Articles

Tet2 deficiency alters CD4+ T cell function and promotes T cell lymphoma with a TFH cell immunophenotype

Tayla B. Heavican-Foral, Yuping Li, Waseem Lone, Alyssa Bouska, Jibin Zhang, Ruimeng Yang, Xuxiang Liu, Ab Rauf Shah, Abdul Rouf Mir, Joseph Rohr, Dylan Jochum, Anurag Kumar, Ravneet Singh Chawla, Catalina Amador, Jiayu Yu, Tyler Herek, Jacob Robinson, Chengfeng Bi, Sunandini Sharma, Tyler Gilbreath, R. Katherine Hyde, Timothy W. McKeithan, Chan-Wang Lio, Anjana Rao, Giorgio Inghirami, Joesph Khoury, Wing C. Chan, Javeed Iqbal
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20250194.
https://doi.org/10.1084/jem.20250194
Published: 28 April 2026
View article titled, Tet2 deficiency alters CD4+ T cell function and promotes T cell lymphoma with a TFH cell immunophenotype
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Includes: Supplementary data
Journal Articles

ASXL1 deficiency causes epigenetic dysfunction, combined immunodeficiency, and EBV-associated lymphoma

Maggie P. Fu, Mehul Sharma, Pariya Yousefi, Sarah M. Merrill, Ryan Tan, Simran Samra, Audi Setiadi, Liam Golding, Bhavi P. Modi, Kate L. Del Bel, Rebecca J. Deyell, Jacob Rozmus, Wingfield Rehmus, Kyla J. Hildebrand, Elliot James, Géraldine Blanchard-Rohner, Susan Lin, Kevin E. Shopsowitz, Jefferson Terry, Anna F. Lee, Britt I. Drögemöller, Allison Matthews, Maja Tarailo-Graovac, Laura Sauvé, Hana Mitchell, Julie S. Prendiville, Julia L. MacIsaac, Kristy Dever, David T.S. Lin, Mandy Meijer, Colin J.D. Ross, Simon R.M. Dobson, Suzanne M. Vercauteren, Wyeth W. Wasserman, Clara D.M. van Karnebeek, Margaret L. McKinnon, Michael S. Kobor, Stuart E. Turvey, Catherine M. Biggs
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20240945.
https://doi.org/10.1084/jem.20240945
Published: 31 July 2025
View article titled, ASXL1 deficiency causes epigenetic dysfunction, combined immunodeficiency, and EBV-associated lymphoma
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Includes: Supplementary data
Journal Articles

Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system

In Special Collection:
JEM Cancer Collection 2025
Geunhyo Jang, Rosa Park, Eduardo Esteva, Pei-Feng Hsu, Jue Feng, Samik Upadhaya, Catherine M. Sawai, Iannis Aifantis, David R. Fooksman, Boris Reizis
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20240587.
https://doi.org/10.1084/jem.20240587
Published: 12 March 2025
View article titled, Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system
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Includes: Supplementary data
Journal Articles

Native stem cell transcriptional circuits define cardinal features of high-risk leukemia

In Special Collection:
2025: The Year in Experimental Medicine
Qing Wang, Francesco Boccalatte, Jason Xu, Giovanni Gambi, Bettina Nadorp, Fatema Akter, Carea Mullin, Ashley F. Melnick, Elizabeth Choe, Anna C. McCarter, Nicole A. Jerome, Siyi Chen, Karena Lin, Sarah Khan, Rohan Kodgule, Jonathan H. Sussman, Petri Pölönen, Javier Rodriguez-Hernaez, Sonali Narang, Kleopatra Avrampou, Bryan King, Aristotelis Tsirigos, Russell J.H. Ryan, Charles G. Mullighan, David T. Teachey, Kai Tan, Iannis Aifantis, Mark Y. Chiang
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20231349.
https://doi.org/10.1084/jem.20231349
Published: 19 February 2025
View article titled, Native stem cell transcriptional circuits define cardinal features of high-risk leukemia
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Includes: Supplementary data
Journal Articles

JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL

Shifa Khaja Saleem, Sarah Decker, Sandra Kissel, Marcus Bauer, Dmitry Chernyakov, Daniela Bräuer-Hartmann, Konrad Aumann, Claudia Wickenhauser, Marco Herling, Oleksandra Skorobohatko, Nimitha Mathew, Cornelius Schmidt, Claudius Klein, Marie Follo, Christine Dierks
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20230681.
https://doi.org/10.1084/jem.20230681
Published: 21 November 2024
View article titled, JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL
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Includes: Supplementary data
Journal Articles

Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease

In Special Collection:
Host-Microbe Interactions 2025 , Multifaceted B Cell Functions and Dysfunctions
Sonia Tejedor Vaquero, Hadas Neuman, Laura Comerma, Xavi Marcos-Fa, Celia Corral-Vazquez, Mathieu Uzzan, Marc Pybus, Daniel Segura-Garzón, Joana Guerra, Lisa Perruzza, Roser Tachó-Piñot, Jordi Sintes, Adam Rosenstein, Emilie K. Grasset, Mar Iglesias, Monica Gonzalez Farré, Joan Lop, Maria Evangelina Patriaca-Amiano, Monica Larrubia-Loring, Pablo Santiago-Diaz, Júlia Perera-Bel, Pau Berenguer-Molins, Monica Martinez Gallo, Andrea Martin-Nalda, Encarna Varela, Marta Garrido-Pontnou, Fabio Grassi, Francisco Guarner, Saurabh Mehandru, Lucia Márquez-Mosquera, Ramit Mehr, Andrea Cerutti, Giuliana Magri
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20230079.
https://doi.org/10.1084/jem.20230079
Published: 19 November 2024
View article titled, Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease
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Includes: Supplementary data
Journal Articles

Aberrant pre-mRNA processing in cancer

In Special Collection:
JEM Cancer Collection 2025
Jeetayu Biswas, Leora Boussi, Eytan Stein, Omar Abdel-Wahab
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (11): e20230891.
https://doi.org/10.1084/jem.20230891
Published: 24 September 2024
View article titled, Aberrant pre-mRNA processing in cancer
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Journal Articles

SETD1B mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma

In Special Collection:
Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Multifaceted B Cell Functions and Dysfunctions
Ana Portelinha, Shenqiu Wang, Sara Parsa, Man Jiang, Alexander N. Gorelick, Sagarajit Mohanty, Soumya Sharma, Elisa de Stanchina, Marjan Berishaj, Chunying Zhao, James Heward, Neeraj K. Aryal, Omid Tavana, Jiayu Wen, Jude Fitzgibbon, Ahmet Dogan, Anas Younes, Ari M. Melnick, Hans-Guido Wendel
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20231143.
https://doi.org/10.1084/jem.20231143
Published: 05 September 2024
View article titled, SETD1B mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma
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Includes: Supplementary data
Journal Articles

Viable mutations of mouse midnolin suppress B cell malignancies

In Special Collection:
Mechanisms and Models of Cancer 2024
Xue Zhong, Nagesh Peddada, James J. Moresco, Jianhui Wang, Yiao Jiang, Jonathan J. Rios, Eva Marie Y. Moresco, Jin Huk Choi, Bruce Beutler
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (6): e20232132.
https://doi.org/10.1084/jem.20232132
Published: 16 April 2024
View article titled, Viable mutations of mouse midnolin suppress B cell malignancies
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Includes: Supplementary data
Journal Articles

Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL

Janneke A. Eken, Marvyn T. Koning, Kristyna Kupcova, Julieta H. Sepúlveda Yáñez, Ruben A.L. de Groen, Edwin Quinten, Jurriaan Janssen, Cornelis A.M. van Bergen, Joost S.P. Vermaat, Arjen Cleven, Marcelo A. Navarrete, Bauke Ylstra, Daphne de Jong, Ondrej Havranek, Hassan Jumaa, Hendrik Veelken
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (5): e20230941.
https://doi.org/10.1084/jem.20230941
Published: 21 March 2024
View article titled, Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL
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Includes: Supplementary data
Journal Articles

CAR-T cell manufacturing: Major process parameters and next-generation strategies

In Special Collection:
Cancer Immunotherapy Update 2024 , JEM Cancer Collection 2024
Melanie Ayala Ceja, Mobina Khericha, Caitlin M. Harris, Cristina Puig-Saus, Yvonne Y. Chen
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (2): e20230903.
https://doi.org/10.1084/jem.20230903
Published: 16 January 2024
View article titled, CAR-T cell manufacturing: Major process parameters and next-generation strategies
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Journal Articles

Stem cell–like reprogramming is required for leukemia-initiating activity in B-ALL

In Special Collection:
Myeloid Stem Cells and Leukemia 2024 , Mechanisms and Models of Cancer 2024 , 2024: The Year in Experimental Medicine
Vincent Fregona, Manon Bayet, Mathieu Bouttier, Laetitia Largeaud, Camille Hamelle, Laura A. Jamrog, Naïs Prade, Stéphanie Lagarde, Sylvie Hebrard, Isabelle Luquet, Véronique Mansat-De Mas, Marie Nolla, Marlène Pasquet, Christine Didier, Ahmed Amine Khamlichi, Cyril Broccardo, Éric Delabesse, Stéphane J.C. Mancini, Bastien Gerby
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (1): e20230279.
https://doi.org/10.1084/jem.20230279
Published: 06 November 2023
View article titled, Stem cell–like reprogramming is required for leukemia-initiating activity in B-ALL
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Includes: Supplementary data
Journal Articles

Twisted: Escape of epitope-edited healthy cells from immune attack

Laura Volta, Markus G. Manz
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (12): e20231635.
https://doi.org/10.1084/jem.20231635
Published: 11 October 2023
View article titled, Twisted: Escape of epitope-edited healthy cells from immune attack
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Journal Articles

Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy

In Special Collection:
Cancer Immunotherapy Update 2024 , JEM Cancer Collection 2024
Romina Marone, Emmanuelle Landmann, Anna Devaux, Rosalba Lepore, Denis Seyres, Jessica Zuin, Thomas Burgold, Corinne Engdahl, Giuseppina Capoferri, Alessandro Dell’Aglio, Clément Larrue, Federico Simonetta, Julia Rositzka, Manuel Rhiel, Geoffroy Andrieux, Danielle N. Gallagher, Markus S. Schröder, Amélie Wiederkehr, Alessandro Sinopoli, Valentin Do Sacramento, Anna Haydn, Laura Garcia-Prat, Christopher Divsalar, Anna Camus, Liwen Xu, Lorenza Bordoli, Torsten Schwede, Matthew Porteus, Jérôme Tamburini, Jacob E. Corn, Toni Cathomen, Tatjana I. Cornu, Stefanie Urlinger, Lukas T. Jeker
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (12): e20231235.
https://doi.org/10.1084/jem.20231235
Published: 29 September 2023
View article titled, Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy
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Includes: Supplementary data
Journal Articles

Skin mesenchymal niches maintain and protect AML-initiating stem cells

In Special Collection:
Myeloid Stem Cells and Leukemia 2024
Lakshmi Sandhow, Huan Cai, Elory Leonard, Pingnan Xiao, Luana Tomaipitinca, Alma Månsson, Makoto Kondo, Xiaoyan Sun, Anne-Sofie Johansson, Karl Tryggvason, Maria Kasper, Marcus Järås, Hong Qian
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (10): e20220953.
https://doi.org/10.1084/jem.20220953
Published: 26 July 2023
View article titled, Skin mesenchymal niches maintain and protect AML-initiating stem cells
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Includes: Supplementary data
Journal Articles

The PML hub: An emerging actor of leukemia therapies

In Special Collection:
Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , JEM Cancer Collection 2024 , Myeloid Stem Cells and Leukemia 2024
Domitille Rérolle, Hugues de Thé
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2023) 220 (8): e20221213.
https://doi.org/10.1084/jem.20221213
Published: 29 June 2023
View article titled, The PML hub: An emerging actor of leukemia therapies
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