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Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging

J Exp Med (2025) 223 (2): e20251805.

https://doi.org/10.1084/jem.20251805

Published: 30 December 2025

View article titled, Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging

Includes: Supplementary data

Journal Articles

Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis

Jiuxing Feng, Baitong Wu, Yu Li, Pengli Sun, Qian Liu, Qianxue Xiao, Jia-Bin Cai, Yimin Zheng, Haonan Chen, Yichi Xu, Yixin Liu, Guo-Ming Shi, Li Tan, Yujiang Geno Shi

J Exp Med (2025) 223 (2): e20251114.

https://doi.org/10.1084/jem.20251114

Published: 26 December 2025

View article titled, Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis

Includes: Supplementary data

Journal Articles

Mechanometabolism instructs hematopoietic stem cell specification

Paulina D. Horton, Alina Syed, Michelle Winkler, Abishek B. Vaidya, Michael Rariden, Neha Arora, Yong Zhou, Michihiro Kobayashi, Momoko Yoshimoto, Hyun Jung Lee, Hyun-Eui Kim, John P. Hagan, Catherine Denicourt, Travis I. Moore, Pamela L. Wenzel

J Exp Med (2025) 223 (3): e20250607.

https://doi.org/10.1084/jem.20250607

Published: 09 December 2025

View article titled, Mechanometabolism instructs hematopoietic stem cell specification

Includes: Supplementary data

Journal Articles

Notch interaction with RUNX factors regulates initiation of the T-lineage program

Yuichi Kama, Ken-ichi Hirano, Kaori Masuhara, Yusuke Endo, Yuka Suzuki, Masanori Fujimoto, Tatsuma Matsuda, Takashi Yahata, Masahiko Kato, Katsuto Hozumi, Tomoaki Tanaka, Hiroyuki Hosokawa

J Exp Med (2025) 223 (2): e20250911.

https://doi.org/10.1084/jem.20250911

Published: 04 December 2025

View article titled, Notch interaction with RUNX factors regulates initiation of the T-lineage program

Includes: Supplementary data

Journal Articles

JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote thrombocytosis

Radek C. Skoda, Olli Silvennoinen

J Exp Med (2025) 222 (12): e20251880.

https://doi.org/10.1084/jem.20251880

Published: 11 November 2025

View article titled, JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote thrombocytosis

Journal Articles

Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells

Matouš Vobořil, Fernando Bandeira Sulczewski, Ryan J. Martinez, K. Maude Ashby, Michael Manoharan Valerio, Juliana Idoyaga, Kristin A. Hogquist

J Exp Med (2025) 223 (1): e20250733.

https://doi.org/10.1084/jem.20250733

Published: 22 October 2025

View article titled, Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells

Journal Articles

Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis

Li Zhou, Dongxiao Wu, Yabo Zhou, Dianheng Wang, Zhuo-Yu An, Peng Zhao, Shaoyang Lai, Zhenfeng Wang, Nannan Zhou, Jie Chen, Jiadi Lv, Xiaohui Zhang, Bo Huang

J Exp Med (2025) 222 (12): e20250153.

https://doi.org/10.1084/jem.20250153

Published: 15 October 2025

View article titled, Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis

Includes: Supplementary data

Journal Articles

Bone marrow neutrophil density regulates myelopoiesis during obesity and weight loss

J Exp Med (2025) 222 (9): e20242174.

https://doi.org/10.1084/jem.20242174

Published: 11 July 2025

View article titled, Bone marrow neutrophil density regulates myelopoiesis during obesity and weight loss

Includes: Supplementary data

Journal Articles

DNGR-1 regulates proliferation and migration of bone marrow dendritic cell progenitors

In Special Collection:

Macrophages and Dendritic Cells in Health and Disease

Ana Cardoso, Michael D. Buck, Bruno Frederico, Probir Chakravarty, Oliver Schulz, Kok Haw Jonathan Lim, Cécile Piot, Mariana Pereira da Costa, Evangelos Giampazolias, Francesca Gasparrini, Neil Rogers, Caetano Reis e Sousa

J Exp Med (2025) 222 (8): e20241813.

https://doi.org/10.1084/jem.20241813

Published: 13 May 2025

View article titled, DNGR-1 regulates proliferation and migration of bone marrow dendritic cell progenitors

Includes: Supplementary data

Journal Articles

Hiding in plain sight: A new lymphoid organ discovered in zebrafish

Mohamed N. Bakr, David M. Langenau

J Exp Med (2025) 222 (6): e20250321.

https://doi.org/10.1084/jem.20250321

Published: 18 April 2025

View article titled, Hiding in plain sight: A new lymphoid organ discovered in zebrafish

Journal Articles

Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system

In Special Collection:

JEM Cancer Collection 2025

Geunhyo Jang, Rosa Park, Eduardo Esteva, Pei-Feng Hsu, Jue Feng, Samik Upadhaya, Catherine M. Sawai, Iannis Aifantis, David R. Fooksman, Boris Reizis

J Exp Med (2025) 222 (6): e20240587.

https://doi.org/10.1084/jem.20240587

Published: 12 March 2025

View article titled, Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system

Includes: Supplementary data

Journal Articles

Native stem cell transcriptional circuits define cardinal features of high-risk leukemia

In Special Collection:

2025: The Year in Experimental Medicine

J Exp Med (2025) 222 (4): e20231349.

https://doi.org/10.1084/jem.20231349

Published: 19 February 2025

View article titled, Native stem cell transcriptional circuits define cardinal features of high-risk leukemia

Includes: Supplementary data

Journal Articles

Inhibition of DEK restores hematopoietic stem cell function in Fanconi anemia

Zhe Chen, Feng Wu, Yan Li, Lei Li, Yufei Lei, Siwei Gao, Tao Chen, Yuxin Xie, Jianwen Xiao, Hanqing Zeng, Jianchuan Deng, Xueya Zhao, Yu Hou

J Exp Med (2025) 222 (3): e20241248.

https://doi.org/10.1084/jem.20241248

Published: 21 January 2025

View article titled, Inhibition of DEK restores hematopoietic stem cell function in Fanconi anemia

Includes: Supplementary data

Journal Articles

Spatiotemporal dynamics of fetal liver hematopoietic niches

In Special Collection:

2025: The Year in Experimental Medicine

Márcia Mesquita Peixoto, Francisca Soares-da-Silva, Valentin Bonnet, Yanping Zhou, Gustave Ronteix, Rita Faria Santos, Marie-Pierre Mailhe, Gonçalo Nogueira, Xing Feng, João Pedro Pereira, Emanuele Azzoni, Giorgio Anselmi, Marella F.T.R. de Bruijn, Archibald Perkins, Charles N. Baroud, Perpétua Pinto-do-Ó, Ana Cumano

J Exp Med (2025) 222 (2): e20240592.

https://doi.org/10.1084/jem.20240592

Published: 07 January 2025

View article titled, Spatiotemporal dynamics of fetal liver hematopoietic niches

Includes: Supplementary data

Journal Articles

Genetic and environmental risks for clonal hematopoiesis and cancer

In Special Collection:

JEM Cancer Collection 2025 , Immunology Update Winter 2025

Stephanie Franco, Lucy A. Godley

J Exp Med (2024) 222 (1): e20230931.

https://doi.org/10.1084/jem.20230931

Published: 03 December 2024

View article titled, Genetic and environmental risks for clonal hematopoiesis and cancer

Journal Articles

Aberrant pre-mRNA processing in cancer

In Special Collection:

JEM Cancer Collection 2025

Jeetayu Biswas, Leora Boussi, Eytan Stein, Omar Abdel-Wahab

J Exp Med (2024) 221 (11): e20230891.

https://doi.org/10.1084/jem.20230891

Published: 24 September 2024

View article titled, Aberrant pre-mRNA processing in cancer

Journal Articles

Transcriptional network dynamics in early T cell development

In Special Collection:

Autoimmunity 2024 , Immunity Review Series

Boyoung Shin, Samantha J. Chang, Brendan W. MacNabb, Ellen V. Rothenberg

J Exp Med (2024) 221 (10): e20230893.

https://doi.org/10.1084/jem.20230893

Published: 21 August 2024

View article titled, Transcriptional network dynamics in early T cell development

Journal Articles

Viable mutations of mouse midnolin suppress B cell malignancies

In Special Collection:

Mechanisms and Models of Cancer 2024

Xue Zhong, Nagesh Peddada, James J. Moresco, Jianhui Wang, Yiao Jiang, Jonathan J. Rios, Eva Marie Y. Moresco, Jin Huk Choi, Bruce Beutler

J Exp Med (2024) 221 (6): e20232132.

https://doi.org/10.1084/jem.20232132

Published: 16 April 2024

View article titled, Viable mutations of mouse midnolin suppress B cell malignancies

Includes: Supplementary data

Journal Articles

Slow cycling and durable Flt3⁺ progenitors contribute to hematopoiesis under native conditions

In Special Collection:

Myeloid Stem Cells and Leukemia 2024

Michael Solomon, Baobao Song, Vinothini Govindarajah, Samantha Good, Ashok Arasu, E. Broderick Hinton, Kairavee Thakkar, James Bartram, Marie-Dominique Filippi, Jose A. Cancelas, Nathan Salomonis, H. Leighton Grimes, Damien Reynaud

J Exp Med (2023) 221 (1): e20231035.

https://doi.org/10.1084/jem.20231035

Published: 01 November 2023

View article titled, Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions

Includes: Supplementary data

Journal Articles

Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection

In Special Collection:

Myeloid Stem Cells and Leukemia 2024

Tengfei Song, Yonghong Yao, Julien Papoin, Barbara Sherry, Betty Diamond, Hua Gu, Lionel Blanc, Yong-Rui Zou

J Exp Med (2023) 220 (12): e20230018.

https://doi.org/10.1084/jem.20230018

Published: 18 October 2023

View article titled, Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection

Includes: Supplementary data

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Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging

Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis

Mechanometabolism instructs hematopoietic stem cell specification

Notch interaction with RUNX factors regulates initiation of the T-lineage program

JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote thrombocytosis

Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells

Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis

Bone marrow neutrophil density regulates myelopoiesis during obesity and weight loss

DNGR-1 regulates proliferation and migration of bone marrow dendritic cell progenitors

Hiding in plain sight: A new lymphoid organ discovered in zebrafish

Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system

Native stem cell transcriptional circuits define cardinal features of high-risk leukemia

Inhibition of DEK restores hematopoietic stem cell function in Fanconi anemia

Spatiotemporal dynamics of fetal liver hematopoietic niches

Genetic and environmental risks for clonal hematopoiesis and cancer

Aberrant pre-mRNA processing in cancer

Transcriptional network dynamics in early T cell development

Viable mutations of mouse midnolin suppress B cell malignancies

Slow cycling and durable Flt3⁺ progenitors contribute to hematopoiesis under native conditions

Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection

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