Article
A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes
The study by Kurz et al. elucidates the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors and highlights the close lineage relationship of the progeny in the perivascular niche.
pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection
Trms rapidly establish antiviral states in barrier tissues during reinfection, but the mechanisms remain unclear. Hernández-García et al. reveal that Trm recruit plasmacytoid DCs (pDCs), which promote antiviral immunity through type I IFNs (IFN-Is).
The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites
This study reveals that host-generated riboflavin breakdown products, including lumichrome and lumiflavin, can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels and may naturally dampen MAIT cell immune activation.
Brief Definitive Report
SLC7A8 is essential for metabolic fitness and function of Th2 cells
Panda et al. identify SLC7A8 as a Th2-specific amino acid transporter essential for Th2 proliferation, cytokine production, and type 2 immunity. Slc7a8 deficiency disrupts metabolism, mTOR, and c-Myc signaling, thereby reducing Th2 responses to helminth infection and allergen-induced inflammation.
