Issues
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Cover Image
Cover Image
ON THE COVER
Immunohistochemical triple staining of IL-33 (green), Iba1 (red), and GFAP (yellow) in the fovea of an 82-year-old female donor diagnosed with age-related macular degeneration. Blue: DAPI (49,6-diamidino-2-phenylindole) staining of the nuclei. Image kindly provided by Dr. Menno van Lookeren Campagne.
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Brief Definitive Report
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70
Chan et al. describe a combination of alleles with hypomorphic and activating mutations in the T cell signaling molecule ZAP-70 in a patient with autoimmunity.
Identification of CD112R as a novel checkpoint for human T cells
Zhu et al. report the identification of CD112R as a new coinhibitory receptor of the TIGIT–DNAM-1 family for human T cells.
Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes
Butyrophilins are proteins secreted during lactation and thought to influence immune function. Sarter et al. generated butyrophilin-2a2–deficient mice to show enhanced effector T cell responses, antitumor responses, and exacerbated EAE due to the impaired APC modulation of T cell immunity.
Article
IL-33 amplifies an innate immune response in the degenerating retina
Xi et al. demonstrate that IL-33 is a key regulator of retinal inflammation and degeneration.
RAG-mediated DNA double-strand breaks activate a cell type–specific checkpoint to inhibit pre–B cell receptor signals
B-lineage cells reconcile the competing needs of proliferation and genome stability.
Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide
Madera et al. show that NK cells unable to receive type I IFN signals during MCMV infection have defective expansion and memory cell formation, possessing increased susceptibility to apoptosis due to NK cell–mediated fratricide.
miR-23∼27∼24 clusters control effector T cell differentiation and function
The miR-23∼27∼24 clusters control differentiation of effector T cells. In particular, miR-24 targets IL-4 and miR-27 targets GATA3, thus collaborating in the control of Th2 immunity.
IL-1–induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation
Lin et al. show that Bhlhe40 expression identifies encephalitogenic CD4+ T helper cells and define a pertussis toxin–IL-1–Bhlhe40 pathway active in experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.
Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression
Klein et al. show that Ptch2 loss in either the niche or in hematopoietic cells drives myeloproliferation and accelerates JAK2V617F-driven pathogenesis, causing transformation of nonlethal chronic MPNs into aggressive lethal leukemias.
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