Review
C/EBPα: critical at the origin of leukemic transformation
Roe and Vakoc discuss the role of C/EBPα in the initiation of acute myeloid leukemia.
Brief Definitive Report
Initiation of MLL-rearranged AML is dependent on C/EBPα
C/EBPα collaborates with MLL-ENL to activate a group of genes that, together with Hoxa9 and Meis1, are responsible for the early events that transforms normal hematopoietic cells into leukemic cells
Article
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells
Estradiol enhances COX-2 expression and prostaglandin biosynthesis in TSC2-deficient cells via a rapamycin-insensitive, mTORC2-dependent mechanism.
Jab1 regulates Schwann cell proliferation and axonal sorting through p27
Jab1 constitutes a regulatory molecule that integrates laminin211 signals in Schwann cells to govern cell cycle, cell number, and differentiation.
Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation
BLyS expression by GC follicular T cells is required for the efficient selection of high-affinity GC B cells.
EndoU is a novel regulator of AICD during peripheral B cell selection
EndoU is a critical regulator of a novel RNA-dependent pathway controlling peripheral B cell survival and antigen responsiveness.
Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs
Musashi-2 is an important regulator of the hematopoietic stem cell translatome and balances HSC homeostasis and lineage bias.
Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids
Inflammatory T helper 17 cells in humans are distinguished by selective expression of MDR1 and are enriched in the gut of patients with Crohn’s disease.
IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo
The signal 3 cytokines interleukin-12 and type I interferon sustain CD8 T cell division by prolonging expression of CD25 in vivo.
CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets
CD44loCD62Lhi regulatory T cells preferentially access IL-2 in T cell zones due to expression of CCR7
TRAF3 regulates the effector function of regulatory T cells and humoral immune responses
The induction of follicular regulatory T cells and control of germinal center reactions require the adaptor protein Traf3, in part because of Traf3-induced expression of ICOS.
Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5–Dusp axis in the osteoclast
The transcription factor Stat5 inhibits the bone-resorbing function of osteoclasts, in part by inducing the expression of the phosphatases Dusp1 and Dusp2.
Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia
Abnormal maternal inflammation leads to TNF-mediated fetal growth restriction and some features of preeclampsia that can be ameliorated with the nitric oxide mimetic nitroglycerin.
