ON THE COVER
Antibodies to the transferrin receptor (TfR) are used to transport therapeutic molecules across the blood-brain barrier. Bien-Ly et al. demonstrate that high-affinity antibodies to TfR trigger internalization and lysosomal degradation of the receptor, impairing the passage of molecules into the brain. These findings help explain the proven superiority of low-affinity anti-TfR antibodies. Image depicts brain endothelial cell nuclei (green) with high-affinity anti-TfR antibodies localizing with the lysosomal marker LAMP1 (red). Art by Lewis Long (firstname.lastname@example.org).
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Brief Definitive Report
Erythropoietin suppresses non-erythroid cell fate options to induce an erythroid lineage bias at all lineage bifurcations between HSCs and committed erythroid progenitors.
The antiviral drug ganciclovir inhibits microglial proliferation and protects against disease in mice with experimental autoimmunity encephalomyelitis.
The transcription factor Gata3 is required for the generation of group 3 innate lymphoid cells (ILC3) that protect mucosal surfaces.
Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells
Hematopoietic stem cells expressing intermediate levels of Kit have superior repopulation capacity after transplantation compared with those expressing high levels of Kit.
High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias
c-Kitlo HSCs exhibit enhanced self-renewal and long-term reconstitution potential and give rise to c-Kithi HSCs that have a megakaryocytic bias.
High-affinity transferrin receptor (TfR) bispecific antibodies facilitate trafficking of TfR to lysosomes and induce TfR degradation to decrease the ability of TfR to mediate BBB transcytosis.
Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons
Quiescence acts as a safeguard mechanism to ensure survival of the HSC pool during chronic IFN-1 exposure
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension
Reduced expression of bone morphogenetic protein receptor 2 subverts a stress granule response, heightens GM-CSF mRNA translation, and increases inflammatory cell recruitment to exacerbate pulmonary arterial hypertension.
Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid
DHA diols produced by Müller cells suppress Notch activation in endothelial cells, thereby promoting retinal angiogenesis.
2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses
Blockade of CD28 signals results in the up-regulation of 2B4 on primary CD8+ effectors and plays a critical role in controlling antigen-specific CD8+ T cell responses.
The deubiquitinase USP21 targets RIG-I for deubiquitination, thus dampening interferon production and activation of IFN-responsive genes in response to RNA viruses.
The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification
CD73 expression is induced in response to TCR ligation and identifies a population of thymocytes that are committed to the γδ T cell fate.
Memory CD8+ T cells require stronger TCR stimulation than naive cells to enter cell cycle due to reduced Zap70 activation and increased levels of protein tyrosine phosphatases.
Monovalent engagement can trigger BCR signal transduction, and fine-tuning of BCR-ligand recognition can lead to B cell nonresponsiveness, activation, or inhibition.