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    ON THE COVER
    Cook et al. show that combining a γ-secretase inhibitor with gemcitabine synergistically kills intratumoral endothelial cells and prolongs survival in mice with advanced pancreatic adenocarcinoma. The authors’ original image shows Meca32-expressing endothelial cells (orange) among Ki67-positive proliferating cells (green) bordering a murine pancreatic tumor.
    See page 437

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ISSN 0022-1007
EISSN 1540-9538
In this Issue

Perspective

Letter

Brief Definitive Report

Blocking Notch signaling in pancreatic cancer promotes hypoxia and cell death.

Polycomb group gene Bmi1 functions as a tumor suppressor in myelofibrosis.

Protection from replicative stress conferred by Chk1 promotes transformation.

A patient with a homozygous premature stop codon in PIK3R1 showed an early developmental block in B cell development but minimal effects in other organ systems.

Bystander activation of human CD8+ T cells specific for influenza or cytomegalovirus during primary Epstein-Barr virus infection does not result in preexisting memory T cell attrition.

Article

Hippo and TGF-β converge on CTGF to promote malignant mesothelioma.

Dendritic cells are transformed to become immunosuppressive during ovarian cancer progression.

Autocrine VEGFR2 signaling in glioma stem-like cells evades VEGF neutralization.

The neurotrophin receptor TrkB is up-regulated on astrocytes in white matter lesions from multiple sclerosis patients, and mice lacking TrkB specifically in astrocytes are more resistant to experimental autoimmune encephalomyelitis–induced neurodegeneration.

Osteoclasts promote the formation of the HSC niche by inducing the differentiation of osteoblastic cells from mesenchymal stem cells.

CXCL12 forms a complex with HMGB1 that binds to the chemokine receptor CXCR4 and increases inflammatory cell migration.

Neutropenia in mice and humans results in the generation of NK cells with an immature and hyporesponsive phenotype.

Female mice lacking DEF6 and SWAP70 develop a lupus-like syndrome through dysregulation of IRF4 in activated B cells and plasma cells.

Early IgM+ and switched Ig+ memory B cells develop from a germinal center (GC)–independent pathway, whereas late switched memory cells are GC dependent.

The repair protein trefoil factor 2 promotes Th2 responses to helminth infection and allergens in part by inducing IL-33.

Erk1/2-dependent TCR decisions, but not negative selection, are impaired in NOD thymocytes, leading to preferential development of αβ CD4+CD8+ thymocytes over γδ thymocytes and saturation of selection niches in TCR tg mouse models.

Correction

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