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Cover Image
Cover Image
ON THE COVER
Horiuchi et al. show that elevated MYC expression sensitizes human triple-negative breast cancers to CDK inhibitors. The original image is a heat map depicting gene expression across a variety of breast cancer subtypes. Artwork by Sylvia Cuadrado.
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Brief Definitive Report
Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection
Memory CD4+ T cell homeostasis and AIDS progression are independent of naive CD4+ T cells in SIV infection of nonhuman primates.
Characterization of resident and migratory dendritic cells in human lymph nodes
Human skin-draining lymph nodes contain functionally distinct subsets of resident and migratory dendritic cells.
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response
Di-methylation of histone H3 at lysine 9 (H3K9me2) suppresses expression of interferon genes, and deletion or inactivation of the lysine methyltransferase G9a converts fibroblasts into interferon-producing cells resistant to RNA viruses.
The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination
MLH1 ATPase activity is essential for class switch recombination but not for somatic hypermutation.
Article
MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition
Triple-negative breast cancers with elevated MYC are sensitized to CDK inhibition.
Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33
HSP90 inhibition depletes STK33 in KRAS mutant tumors.
Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia
Rictor is essential in Notch-driven T-ALL pathogenesis.
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells
Notch signaling is required for the generation of α4β7+RORγt− fetal progenitors, but must then be turned off to allow RORγt expression and LTi cell maturation.
The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes
In mice lacking both Mst1 and Mst2 in the lymphoid compartment, thymocyte development is normal, but single-positive thymocytes exhibit excessive apoptosis and greatly diminished thymic egress, accompanied by loss of chemokine activation of RhoA and Rac1.
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor
Crystal structure and mutagenesis analyses suggest a MAIT TCR–MR1 docking mode distinct from the NKT TCR-CD1d docking mode.
Essential role of EBF1 in the generation and function of distinct mature B cell types
Gain- and loss-of-function analyses reveal that the transcription factor EBF1 is required for normal differentiation and function of marginal zone, B-1, follicular, and germinal center B cells in mice.
Transglutaminase is essential for IgA nephropathy development acting through IgA receptors
Transglutaminase 2 is required for the development of IgA nephropathy.
ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol–induced lipid body formation
The transcription factor ATF3 inhibits lipid body formation in macrophages during atherosclerosis in part by dampening the expression of cholesterol 25-hydroxylase.
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo
Deep vein thrombosis initiation is mediated by cross talk between monocytes, neutrophils, and platelets.
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease
The PET imaging agent CuII(atsm) improves motor and cognitive function in Parkinson’s disease.
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy
Cells from Cockayne syndrome patients and a mouse model of the disease show increased metabolism as a result of impaired autophagy-mediated removal of damaged mitochondria.
A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis
The ER chaperone GRP78/BiP is crucial for the development of rheumatoid arthritis.
