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    ON THE COVER
    Li et al. demonstrate that targeting antigens to human DCs in vivo via the asialoglycoprotein receptor (ASGPR) generates IL-10–producing, antigen-specific CD4+ T cells with suppressive properties. Image shows an abstraction of a staining for ASGPR (dark orange), DAPI (blue), HLA-DR (orange), and CD1c (yellow) in healthy human skin. Artwork by Rachel Urkowitz (rachelurk@earthlink.net).
    See page 109

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ISSN 0022-1007
EISSN 1540-9538
In this Issue

Brief Definitive Report

When fused to a rabies virus glycoprotein peptide that shuttles small RNAs across the blood–brain barrier, an HCMV noncoding RNA that protects mitochondrial Complex I activity, delivered intravenously, shows therapeutic efficacy in a rat model of Parkinson’s disease.

During IgL chain rearrangement in mouse pre–B cells, DNA breaks inflicted by RAG proteins induce Pim2 to promote cell survival and limit proliferation; thus, DNA breaks effectively stand in for the prosurvival cytokine IL-7, whose signaling is attenuated during this stage of B cell development.

ZBTB1, a BTB-ZF family member, is essential for T cell development and for complete B and NK cell differentiation.

A homozygous mutation that gave rise to a stop codon in the WIPF1 gene resulted in WASP protein destabilization and in symptoms resembling those of Wiskott-Aldrich syndrome

Article

Mice expressing a transgene encoding the transcription factor NF-E2 in hematopoietic cells exhibit features of myeloproliferative neoplasms, including thrombocytosis, Epo-independent colony formation, stem and progenitor cell overabundance, leukocytosis, and progression to acute myeloid leukemia.

In situ tetramer staining reveals the presence of islet antigen-reactive CD8+ T cells in pancreatic islets from deceased type 1 diabetes patients.

Early after symptom onset, HCV-specific CD4+ T cell responses are primed and detectable in patients regardless of clinical outcome, but without early antiviral therapy these T cells become exhausted or deleted in chronically infected patients.

Loss of intracellular TRAF1 expression correlates with CD8+ T cell exhaustion and contributes to increased viral load at the chronic stage of HIV and LCMV infection, a phenotype that can be reversed by IL-7 stimulation together with 4-1BB agonist.

P. berghei ANKA parasites deficient in schizont membrane-associated cytoadherence protein reveal a beneficial role for CD36-mediated tissue sequestration in aiding parasite growth.

Targeting antigens to the lectinlike DC-ASGPR receptor on human DCs and in nonhuman primates results in the induction of antigen-specific IL-10–producing CD4+ T cells.

IL-1b signaling augments continued splenic monocyte supply during acute inflammation.

Blood monocytes differentiate into distinct colonic macrophage or dendritic cell subsets depending on the presence or absence of inflammation

HMGN1 is a novel alarmin that signals through TLR4 and is required for LPS-induced immune responses in vivo.

Genetic manipulation reveals that Mule is vital for B cell development, proliferation, and homeostasis as a result of its ability to regulate p53 and ATM.

Gfi1b negatively regulates Rag expression through direct binding to the Rag locus and through inhibition of Foxo1; mice lacking both Gfi1b and Gfi1 exhibit a block in B cell development.

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