Issues

Recent findings and technological advances provide insight into how a few transcription factors work together in complex ways to orchestrate red blood cell differentiation.

Lim domain-binding protein 1, a core subunit of complexes containing Scl, Gata1, and Lmo2, is needed continuously throughout erythropoiesis and megakaryopoiesis in adult mice.

One-time treatment with an antibody against BTLA provides long-term protection against graft-versus-host disease without affecting effector T cell responses to tumors or pathogens.

Extracellular NAD⁺ affects the survival and function of regulatory T cells, and NAD-mediated depletion of regulatory T cells promotes anti-tumor responses in mice.

A BAFF receptor mutation associated with non-Hodgkin lymphoma provides new insight into the proximal players of normal BAFF-R signaling.

The leukemogenic effects of Myc drive recurrent trisomy in a mouse model of acute myeloid leukemia.

The reticulon protein Nogo-B is highly expressed in the lungs, and its loss augments lung inflammation in part as a result of decreased expression of the antiinflammatory protein PLUNC.

Engagement of P2X₇ on mouse dendritic cells, presumably by ATP released in response to contact allergen, is needed for IL-1β production and the sensitization phase of contact hypersensitivity.

IkBβ forms a complex with the NF-κB subunits RelA and c-Rel that inhibits the transcription of IL-1β and other genes. Mice lacking IkBβ are protected against LPS-induced shock.

Cytosolic proliferating cell nuclear antigen (PCNA) binds to procaspases and protects human neutrophils from apoptosis.

By binding to the interleukin 17 receptor (IL-17R), TRAF3 blocks formation of the IL-17R–Act1–TRAF6 complex and inhibits downstream signaling.

Natural killer cell recognition of “missing self” contributes meaningfully to control of mouse cytomegalovirus infection in vivo.

The novel polyI:C-inducible membrane protein INAM triggers dendritic cell–mediated natural killer cell activation.

CD14 interacts with and is essential for the functions of endosomal TLR7 and TLR9 in mice.

In humans and mice, CD8α⁺ conventional dendritic cells are the primary source of interferon-λ released in response to the adjuvant and Toll-like receptor 3 agonist poly IC.

IL-12 is enriched at the immunological synapse in TLR-activated dendritic cells interacting with antigen-specific CD8⁺ T cells; synaptic delivery of IL-12 induces IFN-γ production in the T cell.

Real-time imaging defines the dynamics of TCR and T cell motility during early T cell activation in lymph nodes.

Hsp90 stabilizes and prevents degradation of cytoplasmic activation-induced deaminase.

The leukemogenic effects of Myc drive recurrent trisomy in a mouse model of acute myeloid leukemia.