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    ON THE COVER
    Li et al. present the first crystal structures of invariant natural killer T cell receptors (TCRs) bound to microbial glycolipid–CD1d complexes. TCR binding induced conformational changes in the CD1d-bound microbial glycolipids such that they resembled the shape of CD1d-bound α-galactosylceramide. The Warhol-style image features a repeating sequence of these TCR-bound structures. Artwork by Joshua Graver (joshuagraver@mac.com)
    See page 2383

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ISSN 0022-1007
EISSN 1540-9538
In this Issue

Review

In embryonic stem cells, alterations in chromatin modifications influence the balance between self-renewal and differentiation.

Brief Definitive Report

Tumors or embryonic stem cells bearing foreign mitochondrial DNA are rejected by the innate immune system via a mechanism that depends on MyD88.

Whole-exome sequencing reveals a homozygous splice-site mutation in the gene encoding STIM1 in a child with classic Kaposi sarcoma.

Lethal meningitis triggered by the hypervirulent group B streptococcus clone ST-17 is mediated by a novel surface protein called HvgA.

Removal of regulatory T cells precipitates tissue inflammation and a systemic autoimmune lympho- and myeloproliferative syndrome, even in germ-free mice.

Article

The intestinal parasite H. polygyrus secretes a TGF-β–like molecule that induces regulatory T cells, thus suppressing anti-parasitic effector T cell responses by the host.

The interaction between Tim3 on Th1 cells and galectin-9 on Mycobacterium tuberculosis–infected macrophages restricts the bacterial growth by stimulating caspase-1–dependent IL-1β secretion.

Pathogenic virus-specific T cells can inflict a cytokine storm and lethal disease even in immunosuppressive conditions.

Age-related defects in natural killer cell numbers and function underlie the decreased resistance to mousepox infection in aging mice.

The first crystal structures of iNKT cell TCRs bound to complexes of CD1d and microbe-derived glycolipids provide insight into the structural basis of iNKT cell microbial antigen recognition.

Constant regions of antibodies influence toxin neutralization in a manner dependent on FcγR.

Mice lacking both PTEN and SHIP phosphatases develop spontaneous B cell lymphoma.

The actin cross-linking protein filamin A reduces migration, invasion, and metastasis of breast cancer cells.

The hypoxic environment of tumors dictates the phenotype of local myeloid-derived suppressor cells (MDSCs) via HIF-1a expression; hypoxia converts splenic MDSCs from specific into nonspecific suppressors.

Immunotherapy with IL-2 and anti-CD40 induces the expression of NOS2 in tumor-associated macrophages, and its expression is required for the inhibition of tumor metastasis.

Killing of nonmalignant stroma requires cooperation between CD4+ and CD8+ T cells during the effector phase in the tumor microenvironment.

Memory CD4+ T cells that produce both Th2 and Th17 cytokines are increased in the blood of patients with atopic asthma and in the lungs of asthmatic mice, where they contribute to inflammation.

Trithorax group complex is needed for initiation as well as maintenance of GATA3 gene expression in Th2 cells.

Cyclin-dependent kinase 5 drives T cell activation and disease in EAE in part by regulating the actin binding protein coronin 1a.

By inhibiting Nedd8, Tbata suppresses thymic epithelial cell proliferation and thymus size in mice.

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