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Volume 204, Issue 5
14 May 2007
Issue Cover
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  • Cover Image

    Cover Image

    issue cover

    ON THE COVER
    Marking cells that have ever had AID activity (yellow) reveals that B cells turn on this enzyme during maturation and turn it off after differentiating into plasma or memory cells. Confocal microscopy by Makiko Takizawa and Kristien Zaal of NIAMS, NIH. Related article by Crouch et al.
    See page 1145

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ISSN 0022-1007
EISSN 1540-9538

In This Issue

Keeping track of AID
Hema Bashyam
View Articletitled, Keeping track of AID
B cells blunt neonatal immunity
Hema Bashyam
View Articletitled, B cells blunt neonatal immunity
Avoiding fetal loss
Hema Bashyam
View Articletitled, Avoiding fetal loss
Breast cancer hijacks dendritic cells
Hema Bashyam
View Articletitled, Breast cancer hijacks dendritic cells
Lipid tails dictate NKT cell response
Hema Bashyam
View Articletitled, Lipid tails dictate NKT cell response

From the Archive

Interleukin-12: A master regulator
Hema Bashyam
View Articletitled, Interleukin-12: A master regulator

Brief Definitive Report

NF90 regulates inducible IL-2 gene expression in T cells
Lingfang Shi,Wayne R. Godfrey,Joseph Lin,Guohua Zhao,Peter N. Kao
View Articletitled, NF90 regulates inducible IL-2 gene expression in T cells
Increased frequencies of CD4+CD25high regulatory T cells in acute dengue infection
Kerstin Lühn,Cameron P. Simmons,Edward Moran,Nguyen Thi Phuong Dung,Tran Nguyen Bich Chau,Nguyen Than Ha Quyen,Le Thi Thu Thao,Tran Van Ngoc,Nguyen Minh Dung,Bridget Wills,Jeremy Farrar,Andrew J. McMichael,Tao Dong,Sarah Rowland-Jones
View Articletitled, Increased frequencies of CD4<sup>+</sup>CD25<sup>high</sup> regulatory T cells in acute dengue infection
Type I interferon signaling is required for activation of the inflammasome during Francisella infection
Thomas Henry,Anna Brotcke,David S. Weiss,Lucinda J. Thompson,Denise M. Monack
View Articletitled, Type I interferon signaling is required for activation of the inflammasome during <em>Francisella</em> infection
Identification of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia
Marie-Laure Michel,Alexandre Castro Keller,Christophe Paget,Masakazu Fujio,François Trottein,Paul B. Savage,Chi-Huey Wong,Elke Schneider,Michel Dy,Maria C. Leite-de-Moraes
View Articletitled, Identification of an IL-17–producing NK1.1<sup>neg</sup> iNKT cell population involved in airway neutrophilia
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis
Simone Difilippantonio,Arkady Celeste,Michael J. Kruhlak,Youngsoo Lee,Michael J. Difilippantonio,Lionel Feigenbaum,Stephen P. Jackson,Peter J. McKinnon,André Nussenzweig
View Articletitled, Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

Article

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling
Tatsukata Kawagoe,Shintaro Sato,Andreas Jung,Masahiro Yamamoto,Kosuke Matsui,Hiroki Kato,Satoshi Uematsu,Osamu Takeuchi,Shizuo Akira
View Articletitled, Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling
A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity
Tae Whan Kim,Kirk Staschke,Katarzyna Bulek,Jianhong Yao,Kristi Peters,Keun-Hee Oh,Yvonne Vandenburg,Hui Xiao,Wen Qian,Tom Hamilton,Booki Min,Ganes Sen,Raymond Gilmour,Xiaoxia Li
View Articletitled, A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity
Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development
Caroline Aspord,Alexander Pedroza-Gonzalez,Mike Gallegos,Sasha Tindle,Elizabeth C. Burton,Dan Su,Florentina Marches,Jacques Banchereau,A. Karolina Palucka
View Articletitled, Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4<sup>+</sup> T cells that facilitate tumor development
Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers
Rashmi Sood,Mark Zogg,Randal J. Westrick,Yi-he Guo,Edward J. Kerschen,Guillermina Girardi,Jane E. Salmon,Shaun R. Coughlin,Hartmut Weiler
View Articletitled, Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
Ludovic Arnold,Adeline Henry,Françoise Poron,Yasmine Baba-Amer,Nico van Rooijen,Anne Plonquet,Romain K. Gherardi,Bénédicte Chazaud
View Articletitled, Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
Expression of lymphotoxin-αβ on antigen-specific T cells is required for DC function
Leslie E. Summers-deLuca,Douglas D. McCarthy,Bojana Cosovic,Lesley A. Ward,Calvin C. Lo,Stefanie Scheu,Klaus Pfeffer,Jennifer L. Gommerman
View Articletitled, Expression of lymphotoxin-αβ on antigen-specific T cells is required for DC function
Semaphorin 7A plays a critical role in TGF-β1–induced pulmonary fibrosis
Hye-Ryun Kang,Chun Geun Lee,Robert J. Homer,Jack A. Elias
View Articletitled, Semaphorin 7A plays a critical role in TGF-β<sub>1</sub>–induced pulmonary fibrosis
A subset of dendritic cells induces CD4+ T cells to produce IFN-γ by an IL-12–independent but CD70-dependent mechanism in vivo
Helena Soares,HaeNa Waechter,Nicholas Glaichenhaus,Evelyne Mougneau,Hideo Yagita,Olga Mizenina,Diana Dudziak,Michel C. Nussenzweig,Ralph M. Steinman
View Articletitled, A subset of dendritic cells induces CD4<sup>+</sup> T cells to produce IFN-γ by an IL-12–independent but CD70-dependent mechanism in vivo
Type I interferons protect neonates from acute inflammation through interleukin 10–producing B cells
Xiaoming Zhang,Edith Deriaud,Xinan Jiao,Deborah Braun,Claude Leclerc,Richard Lo-Man
View Articletitled, Type I interferons protect neonates from acute inflammation through interleukin 10–producing B cells
Mature natural killer cell and lymphoid tissue–inducing cell development requires Id2-mediated suppression of E protein activity
Markus D. Boos,Yoshifumi Yokota,Gerard Eberl,Barbara L. Kee
View Articletitled, Mature natural killer cell and lymphoid tissue–inducing cell development requires Id2-mediated suppression of E protein activity
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation
Corinna McCarthy,Dawn Shepherd,Sebastian Fleire,Victoria S. Stronge,Michael Koch,Petr A. Illarionov,Giovanna Bossi,Mariolina Salio,Galit Denkberg,Faye Reddington,Andrea Tarlton,B. Gopal Reddy,Richard R. Schmidt,Yoram Reiter,Gillian M. Griffiths,P. Anton van der Merwe,Gurdyal S. Besra,E. Yvonne Jones,Facundo D. Batista,Vincenzo Cerundolo
View Articletitled, The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation
Regulation of AID expression in the immune response
Elizabeth E. Crouch,Zhiyu Li,Makiko Takizawa,Stefan Fichtner-Feigl,Polyxeni Gourzi,Carolina Montaño,Lionel Feigenbaum,Patrick Wilson,Siegfried Janz,F. Nina Papavasiliou,Rafael Casellas
View Articletitled, Regulation of AID expression in the immune response
Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1–transformed acute lymphoblastic leukemia cells
Niklas Feldhahn,Nadine Henke,Kai Melchior,Cihangir Duy,Bonaventure Ndikung Soh,Florian Klein,Gregor von Levetzow,Bernd Giebel,Aihong Li,Wolf-Karsten Hofmann,Hassan Jumaa,Markus Müschen
View Articletitled, Activation-induced cytidine deaminase acts as a mutator in <em>BCR-ABL1</em>–transformed acute lymphoblastic leukemia cells
CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3–kinase– independent manner
François Asperti-Boursin,Eliana Real,Georges Bismuth,Alain Trautmann,Emmanuel Donnadieu
View Articletitled, CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3–kinase– independent manner
Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
Michael M. Zangani,Marianne Frøyland,Gao Yue Qiu,Leonardo A. Meza-Zepeda,Jeffery L. Kutok,Keith M. Thompson,Ludvig A. Munthe,Bjarne Bogen
View Articletitled, Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
CD8 single-cell gene coexpression reveals three different effector types present at distinct phases of the immune response
António Peixoto,César Evaristo,Ivana Munitic,Marta Monteiro,Alain Charbit,Benedita Rocha,Henrique Veiga-Fernandes
View Articletitled, CD8 single-cell gene coexpression reveals three different effector types present at distinct phases of the immune response
A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair
Sophie Péron,Qiang Pan-Hammarström,Kohsuke Imai,Likun Du,Nadine Taubenheim,Ozden Sanal,Laszlo Marodi,Anne Bergelin-Besançon,Malika Benkerrou,Jean-Pierre de Villartay,Alain Fischer,Patrick Revy,Anne Durandy
View Articletitled, A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair
Cytomegalovirus exploits IL-10–mediated immune regulation in the salivary glands
Ian R. Humphreys,Carl de Trez,April Kinkade,Chris A. Benedict,Michael Croft,Carl F. Ware
View Articletitled, Cytomegalovirus exploits IL-10–mediated immune regulation in the salivary glands
Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy
Blanche Schroen,Joost J. Leenders,Arie van Erk,Anne T. Bertrand,Mirjam van Loon,Rick E. van Leeuwen,Nard Kubben,Rudy F. Duisters,Mark W. Schellings,Ben J. Janssen,Jacques J. Debets,Michael Schwake,Morten A. Høydal,Stephane Heymans,Paul Saftig,Yigal M. Pinto
View Articletitled, Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy

Correction

Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock
Chul-Su Yang,Dong-Seok Lee,Chang-Hwa Song,Se-Jin An,Shengjin Li,Jin-Man Kim,Cuk Seong Kim,Dae Goon Yoo,Byeong Hwa Jeon,Hee-Young Yang,Tae-Hoon Lee,Zee-Won Lee,Jamel El-Benna,Dae-Yeul Yu,Eun-Kyeong Jo
View Articletitled, Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock

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