Intracellular distribution of ZAP70 in human Jurkat T cells. Wild-type cells were stimulated for 1 min with 10 μg/ml of anti-CD3 antibody OKT3. After fixation and permeabilization, the cells were incubated with a ZAP70-specific antiserum and then double-stained with both a fluoresceinated goat anti–rabbit Ig antibody and a Texas red–labeled goat anti–mouse Ig antibody. ZAP70 (green) appears clearly concentrated near the plasma membrane, where the TCR–CD3 complex (red) is located. See related article in this issue by Sahuquillo et al., pp. 1179–1192.
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Aminooxypentane-RANTES Induces CCR5 Internalization but Inhibits Recycling: A Novel Inhibitory Mechanism of HIV Infectivity
T Cell–mediated Pathology in Two Models of Experimental Colitis Depends Predominantly on the Interleukin 12/Signal Transducer and Activator of Transcription (Stat)-4 Pathway, but Is Not Conditional on Interferon γ Expression by T Cells
Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production
Brief Definitive Report