In This Issue
People & Ideas
The nucleotide excision repair preincision complex assembles on chromatin even in the absence of DNA damage through the sequential and ordered addition of its individual subunits.
Cis-acting DNA sequence at a replication origin promotes repeat expansion to fragile X full mutation
An SNP upstream of the CGG repeats located at a replication initiation site may contribute to origin inactivation, to altered replication fork progression through the CGG repeats, and repeat expansion to fragile X full mutation.
Sphingomyelin homeostasis is required to form functional enzymatic domains at the trans-Golgi network
Sphingomyelin-mediated organization of resident transmembrane proteins into specific membrane domains at the trans-Golgi network is necessary for normal enzymatic activity.
Stabilization of oscillatory UNC-40 clustering by its ligand UNC-6 directs localized F-actin generation and polarization of cells.
The cofilin CFL-1 recruits actin to the P-type calcium ATPase SPCA1 at the trans-Golgi network, thereby activating the ATPase, promoting Ca2+ influx, and driving secretory cargo sorting.
Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
The Parkinson’s disease–associated proteins PINK1 and Parkin mediate local mitophagy of dysfunctional mitochondria in distal neuronal axons, abrogating the need for retrograde organelle transport and ensuring rapid neuroprotection.
Male Drosophila reproductive glands secrete exosomes in a BMP-dependent manner that fuse with sperm after mating and suppress female remating.