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In Focus

Study reveals how the Sac1 phosphatase removes PtdIns4P from early Golgi membranes.

People & Ideas

McBride studies mitochondrial dynamics and mitochondrial trafficking with other organelles.



During Xenopus development, increased nuclear cPKC activity and decreased nuclear association of lamins mediate nuclear scaling.

Characterization of the structure of the N-terminal portion of yeast Sac1 in complex with the phosphatidylinositol 4-kinase effector Vps74 identifies how Sac1 is directed to dephosphorylate PtdIns4P in the Golgi.


Phosphorylated RPA recruits repair factors to stalled forks, thereby enhancing fork integrity during replication stress.

During kinetochore assembly in budding yeast, the key steps of CENP-A recognition and outer kinetochore recruitment are executed through different yeast CCAN subunits, potentially protecting against inappropriate kinetochore assembly.

The oxidoreductases activity of MagT1, an ER-localized thioredoxin homologue, is necessary for posttranslocational N-glycosylation of acceptor sites that lie proximal to cysteine residues.

The sea urchin sperm guanylyl cyclase chemoreceptor achieves ultrasensitive signal detection and precise signal modulation through high receptor density, subnanomolar ligand affinity, and sequential dephosphorylation.

With just two nebulin repeats, the Drosophila protein Lasp controls muscle thin filament length and filament spacing.

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