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Cover Image
Cover Image
On the cover
Schiefermeier et al. reveal that late endosomes carrying the signal transduction scaffold protein MP1 (green) target focal adhesions (red) and promote their turnover by triggering dissociation of the cytoskeletal regulator IQGAP1. F-actin is labeled blue.
Image © 2014 Schiefermeier et al.
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In This Issue
In Focus
Mitochondrial caspase keeps autophagy in flux
The Drosophila caspase Dcp-1 promotes autophagy by regulating mitochondrial morphology and cellular ATP levels.
People & Ideas
Review
Report
PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo
DNA replication is asymmetrically regulated in the two-cell stage C. elegans embryo by the PAR-4 and PAR-1 polarity proteins, which function independently of known regulators of cell cycle timing to dampen DNA replication dynamics specifically in the posterior blastomere.
Article
Mammalian microtubule P-body dynamics are mediated by nesprin-1
Nesprin-1 is a multi-functional processing body component and microtubule scaffold that is necessary for RNA granule dynamics.
The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB
A nonapoptotic function of the Dcp-1 caspase regulates mitochondrial morphology and promotes autophagy in Drosophila by negatively regulating SesB and ATP levels.
Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons
Ca2+-dependent RNA–protein interactions enable activity-inducible RNA transport in dendrites.
Assembly factors monitor sequential hemylation of cytochrome b to regulate mitochondrial translation
Assembly of the two heme b cofactors into the respiratory chain complex III subunit cytochrome b occurs in a step-by-step process that is monitored by assembly factors and regulates additional cytochrome b synthesis through a feedback loop.
The late endosomal p14–MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration
Late endosomes locally regulate cell migration by transporting the p14–MP1 scaffold complex to the vicinity of focal adhesions.
CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status
The integrated activities of Aurora B and CENP-I generate a molecular switch that maintains a robust spindle checkpoint signal at prometaphase kinetochores until they attain mature attachments to microtubules.
A TOGL domain specifically targets yeast CLASP to kinetochores to stabilize kinetochore microtubules
The two different TOGL domains of the budding yeast CLASP Stu1 are responsible for its distinct mitotic activities, and these activities are only partially mediated by tight microtubule binding.
An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E–PlexinD1 signaling
The RhoGAP protein SH3BP1 mediates Sema3E-induced cell collapse through interaction with PlexinD1 and regulation of Rac1 activity.
Tools
A new probe for super-resolution imaging of membranes elucidates trafficking pathways
mCLING is a novel membrane probe for the study of membrane trafficking with demonstrated value in both live and fixed cells across a wide range of biological systems.
