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Cover Image
Cover Image
On the cover
An Arabidopsis root tip expresses GFP-tagged SINE1 (green), one of many new outer nuclear membrane KASH proteins that Zhou et al. identify in plants. The plant cell walls are labeled with propidium iodide (red).
Image © 2014 Zhou et al.
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In This Issue
In Focus
CNTD1’s crossover act
The cyclin-related protein selects the sites of homologous recombination in meiotic cells.
People & Ideas
Adam Cohen: Visualizing cellular voltage
Cohen uses rhodopsins as optical sensors of cellular voltage.
Review
Report
Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites
CNTD1 coordinates the maturation and designation of meiotic crossover sites from an excess pool of double-strand break intermediates by regulating dynamic changes in key protein complexes associated with these sites.
Article
A selfish DNA element engages a meiosis-specific motor and telomeres for germ-line propagation
The yeast 2 micron plasmid engages a meiosis-specific motor that orchestrates telomere-led chromosome movements for its telomere-associated segregation during meiosis I.
BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis
The major role of BRCA1 in meiosis is not in meiotic recombination but instead in promotion of the dramatic chromatin changes required for formation and function of the XY body.
Identification of unique SUN-interacting nuclear envelope proteins with diverse functions in plants
A new homology search algorithm identifies novel KASH protein family members in Arabidopsis that act at the nuclear envelope in nuclear positioning and innate immunity.
Regulation of cargo recognition, commitment, and unloading drives cotranslational protein targeting
Active and sequential regulation of the interaction of SRP with translating ribosomes drives efficient and faithful cotranslational protein targeting to the target membrane.
Rab18 and a Rab18 GEF complex are required for normal ER structure
The Rab3GAP complex that is mutated in the neurological disorder Micro syndrome is a guanine nucleotide exchange factor that promotes Rab18 localization to the endoplasmic reticulum.
Actin and dynamin2 dynamics and interplay during clathrin-mediated endocytosis
Actin assembly influences the precise temporal and quantitative recruitment of dynamin2 to sites of clathrin-mediated endocytosis.
Talin regulates moesin–NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis
Talin binds directly to moesin in vitro and recruits a moesin–NHE-1 complex to invadopodia to promote tumor cell invasion.
