On the cover
An Arabidopsis root tip expresses GFP-tagged SINE1 (green), one of many new outer nuclear membrane KASH proteins that Zhou et al. identify in plants. The plant cell walls are labeled with propidium iodide (red).
Image © 2014 Zhou et al.
See page 677.
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In This Issue
People & Ideas
Cell biology of disease
Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites
CNTD1 coordinates the maturation and designation of meiotic crossover sites from an excess pool of double-strand break intermediates by regulating dynamic changes in key protein complexes associated with these sites.
The yeast 2 micron plasmid engages a meiosis-specific motor that orchestrates telomere-led chromosome movements for its telomere-associated segregation during meiosis I.
BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis
The major role of BRCA1 in meiosis is not in meiotic recombination but instead in promotion of the dramatic chromatin changes required for formation and function of the XY body.
A new homology search algorithm identifies novel KASH protein family members in Arabidopsis that act at the nuclear envelope in nuclear positioning and innate immunity.
Active and sequential regulation of the interaction of SRP with translating ribosomes drives efficient and faithful cotranslational protein targeting to the target membrane.
The Rab3GAP complex that is mutated in the neurological disorder Micro syndrome is a guanine nucleotide exchange factor that promotes Rab18 localization to the endoplasmic reticulum.
Actin assembly influences the precise temporal and quantitative recruitment of dynamin2 to sites of clathrin-mediated endocytosis.
Talin binds directly to moesin in vitro and recruits a moesin–NHE-1 complex to invadopodia to promote tumor cell invasion.