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Cover Image
Cover Image
On the cover
Quick-freeze, deep-etch transmission electron microscopy of myotube plasma membranes shows an abundance of large clathrin lattices (depicted in various pseudocolors) associated with branched actin filaments. Vassilopoulos et al. reveal that these clathrin plaques help to organize skeletal muscle sarcomeres and attach them to the muscle cell membrane.
Image © 2014 Vassilopoulos et al.
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In This Issue
In Focus
Clathrin’s muscle-building regimen
The clathrin heavy chain forms a membrane scaffold that organizes skeletal muscle sarcomeres.
People & Ideas
Carole Parent: Migrating cells relay the message
Parent studies cell motility in Dictyostelium, neutrophils, and cancer cells.
Review
Report
The p53-induced factor Ei24 inhibits nuclear import through an importin β–binding–like domain
The p53-induced protein Ei24 can bind specifically to importin-β1 and importin-α2 to impede their normal role in nuclear import.
Pericentromere tension is self-regulated by spindle structure in metaphase
Pericentromere tension in yeast is substantial and is tightly self-regulated by the metaphase mitotic spindle through adjustments in spindle structure.
Article
Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation
Hedgehog signaling in Drosophila ovarian follicle stem cells induces expression of Yorkie, the transcriptional coactivator of the Hippo pathway, and both pathways are essential for follicle stem cell maintenance.
Chk2 prevents mitotic exit when the majority of kinetochores are unattached
As an essential step of the spindle checkpoint, Chk2 stabilizes Mps1 and phosphorylates Aurora B to prevent mitotic exit when most kinetochores remain unattached.
The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 during fission yeast cytokinesis
In fission yeast, Rng8 and Rng9 form oligomers and cluster multiple Myo51 dimers to regulate Myo51 localization and function during cytokinesis.
Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization
Clathrin heavy chain contributes to the formation and maintenance of the contractile apparatus in skeletal muscle through interactions with costameric proteins.
Plasma membrane phosphoinositide balance regulates cell shape during Drosophila embryo morphogenesis
The ratio of different phosphoinositide species coordinates actomyosin contractility and plasma membrane expansion during tissue morphogenesis, thus ensuring proper cell shape.
Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-β
The matrix glycoprotein tenascin-X regulates the bioavailability of mature TGF-β through an α11β1 integrin–dependent mechanism that promotes epithelial-to-mesenchymal transition.
