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The clathrin heavy chain forms a membrane scaffold that organizes skeletal muscle sarcomeres.

People & Ideas

Parent studies cell motility in Dictyostelium, neutrophils, and cancer cells.


Cell biology of disease


The p53-induced protein Ei24 can bind specifically to importin-β1 and importin-α2 to impede their normal role in nuclear import.

Pericentromere tension in yeast is substantial and is tightly self-regulated by the metaphase mitotic spindle through adjustments in spindle structure.


Hedgehog signaling in Drosophila ovarian follicle stem cells induces expression of Yorkie, the transcriptional coactivator of the Hippo pathway, and both pathways are essential for follicle stem cell maintenance.

As an essential step of the spindle checkpoint, Chk2 stabilizes Mps1 and phosphorylates Aurora B to prevent mitotic exit when most kinetochores remain unattached.

In fission yeast, Rng8 and Rng9 form oligomers and cluster multiple Myo51 dimers to regulate Myo51 localization and function during cytokinesis.

Clathrin heavy chain contributes to the formation and maintenance of the contractile apparatus in skeletal muscle through interactions with costameric proteins.

The ratio of different phosphoinositide species coordinates actomyosin contractility and plasma membrane expansion during tissue morphogenesis, thus ensuring proper cell shape.

The matrix glycoprotein tenascin-X regulates the bioavailability of mature TGF-β through an α11β1 integrin–dependent mechanism that promotes epithelial-to-mesenchymal transition.

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