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Cover Image
Cover Image
On the cover
β-Galactosidase activity (blue) indicates senescent cells in the liver of hyperthyroid mice. Zambrano et al. describe how thyroid hormone and its receptor cause increased mitochondrial respiration and reactive oxygen species production, leading to DNA damage and premature cell senescence.
Image © 2014 Zambrano et al.
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In This Issue
In Focus
Sending sisters their separate ways
Repair protein helps resolve entanglements between sister chromatids.
People & Ideas
Michael Kozlov: A twist in membrane physics
Kozlov studies the biophysics of membrane shape and behavior.
Review
Report
Adducin-1 is essential for mitotic spindle assembly through its interaction with myosin-X
The actin-binding protein ADD1 associates with mitotic spindles through Myo10 and is crucial for proper spindle assembly and mitotic progression.
Article
New histone supply regulates replication fork speed and PCNA unloading
Coupling of replication fork speed and PCNA unloading to nucleosome assembly may maintain chromatin integrity during transient histone shortage.
TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability
TopBP1/Dpb11 prevents accumulation of anaphase chromatin bridges by stimulating the Mec1/ATR kinase and suppressing homologous recombination.
Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus
A long noncoding RNA directly builds an intrachromosomal interaction complex to establish allele-specific transcriptional gene silencing over a large chromosomal domain.
Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2
Phosphorylation of synaptic cytoskeletal components by casein kinase 2 promotes the development and maintenance of synaptic connections.
Cytoplasmic protein methylation is essential for neural crest migration
Post-translational methylation of the non-histone, actin-binding protein EF1α1 is essential for neural crest migration.
Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation
The guanine nucleotide exchange factor Dbl3 promotes spatially restricted Cdc42 activation in the apical zone, regulating apical morphogenesis and tight junction positioning.
The thyroid hormone receptor β induces DNA damage and premature senescence
Thyroid hormone and its receptor act in concert with NRF1 to increase cellular respiration and reactive oxygen species production, leading to DNA damage and premature senescence in susceptible cells.
