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Cover Image
Cover Image
On the cover
Immunohistochemical staining of an invasive ductal carcinoma shows the presence of activated focal adhesion kinase (brown) in both the tumor and the endothelial cells of stromal blood vessels. Nuclei are labeled blue. Jean et al. reveal that inhibiting endothelial focal adhesion kinase prevents tumor metastasis by enhancing endothelial barrier function.
Image © 2014 Jean et al.
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In This Issue
In Focus
Clearing the way for cancer cells
Endothelial focal adhesion kinase helps tumor cells enter the bloodstream.
People & Ideas
Jonathon Howard: Motor proteins go walkabout
Howard studies motor proteins and how they shape cell behaviors.
Review
Report
DNA replication and spindle checkpoints cooperate during S phase to delay mitosis and preserve genome integrity
S phase, G2/M phase, and spindle assembly checkpoints all cooperate to restrain mitosis transiently when replication forks are progressing normally.
Motor-driven marginal band coiling promotes cell shape change during platelet activation
During platelet activation, motor protein-induced coiling of the microtubule-based marginal band leads to the cells’ characteristic spherical shape, whereas actomyosin-mediated compression of the coil results in new microtubule polymerization in a smaller ring.
Article
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins
Small heat shock proteins translocate to unfolded titin Ig domains under stress conditions to prevent titin aggregation and myocyte stiffening.
Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm
Pih1d3 promotes the stability and assembly of axonemal outer and inner dynein arms to allow for cytoplasmic preassembly of dynein complexes in spermatogenic cells.
The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly
Talpid3 and Cep290 promote proper ciliary vesicle formation by regulating centriolar satellite accretion and Rab8a localization.
TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO–IKK supramolecular structures
The mechanism of NEMO recruitment into supramolecular complexes and its dependence on ubiquitination differs in response to the proinflammatory cytokines TNF and IL-1.
Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function
Endothelial cell focal adhesion kinase is a key intermediate between c-Src and the regulation of endothelial cell barrier function in the control of tumor metastasis.
Tools
A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell–cell adhesion
A genome-wide screen identifies 17 regulatory hubs that modulate the levels of the core cadherin–catenin complex and coordinate cadherin-mediated cell–cell adhesion.
