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    Telley et al. develop a cell-free assay to determine how nuclei disperse through the syncitium of early Drosophila embryos. Condensed chromosomes (red) align on a metaphase spindle (green) in a droplet of cytoplasm extracted from a preblastoderm embryo. After anaphase, the newly formed nuclei are spatially separated by the migration of the microtubule asters through the cytoplasm. Image courtesy of Ivo A. Telley.
    See page 887.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Researchers discover how nuclei in insect embryos travel to the cortex.

People & Ideas

Grebe studies the establishment and maintenance of cell and tissue polarity in plants



CtIP-dependent DNA end resection, which was previously thought to be necessary for CHK1 kinase activation and subsequent DNA damage checkpoint induction, is in fact only required for sustained checkpoint signaling.

Loss of both meiosis-specific kleisins in mice reveals conserved functions of the meiotic cohesin complexes in axial element formation during spermatogenesis.

A cell-free system using cytoplasmic extract from single–Drosophila syncytial embryos reveals that the spacing between nuclei is preprogrammed and relies on microtubule aster migration.

Use of transgenic mouse eggs expressing human zona pellucida proteins identifies an N-terminal domain of ZP2 that is essential for human sperm–egg binding.


Kinase-inhibited FAK limits VCAM-1 production via nuclear localization and promotion of GATA4 turnover.

Diffusion barriers and the dumbbell shape of the anaphase nucleus promote nuclear compartmentalization and asymmetric protein inheritance during closed mitosis in yeast.

Actin veil networks assembled by the Arp2/3 complex constrain myosin II–dependent contractility in neuronal growth cones with consequent effects on peripheral retrograde actin flow rates.

The two head domains of the budding yeast Kinesin-14 Kar3Vik1 bind adjacent protofilaments at the start of the motility cycle, followed by release of Vik1 from one protofilament to allow the motor’s powerstroke.

The dynein-associated protein Lis1 may be a ubiquitous determinant of dynein-dependent transport required primarily at the stage of motility initiation.

EGF signaling activates Rab5c and promotes the intracellular association of AMAP1 and PRKD2 to enhance β1 integrin recycling and promote the invasiveness of breast cancer cells.

Smad3/Akt/mTOR/S6K/S6RP signaling plays a critical role in follistatin-mediated muscle growth that operates independently of myostatin-driven mechanisms.

Sarcospan signals through Akt to increase cell surface levels of utrophin and glycosylated α-dystroglycan and promote muscle repair after injury.


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