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In This Issue

In Focus

Meshing experiments and simulations, study uncovers the stoichiometry of actin-polymerizing proteins.

People & Ideas

Raposo studies the biogenesis of melanosomes as exemplars of lysosome-related organelles.



Relative to vinculin, a unique 68-residue insert in the C-terminal tail of metavinculin results in a loss of actin filament-bundling activity but gain of actin filament-severing activity.

Mgr2 is a new component of the mitochondrial presequence translocase required for efficient coupling of the TIM23 core complex to Tim21, respiratory chain complexes, and the translocase of the outer mitochondrial membrane.

Talin binding to the integrin β tail alters the β transmembrane domain’s topology, resulting in integrin activation.


A novel telomere-protection mechanism relies upon nucleostemin-mediated recruitment of PML-IV to telomeres and subsequent recruitment of RAD51 in both ALT and telomerase-active cells.

Showing convergence with budding yeast mitotic exit network signaling, the LATS1/WARTS kinase phosphorylates the MYPT1 phosphatase to control PLK1 at the G2 DNA damage checkpoint.

A combination of computational modeling and quantitative experimentation demonstrates that actin polymerization depends on Nck density as a result of a 4:2:1 Nck/N-WASp/Arp2/3 stoichiometry.

The noncatalytic RabGAP protein TBC1D14 regulates the Rab11- and ULK1-positive recycling endosomes required for autophagosome formation upon starvation

QBRICK facilitates the integrin α8β1–dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin.

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